Equine sTREM2 antibody and antigen (recombinant protein)

Diagnostic anti-Equine sTREM2 antibodies pairs and antigen for animal health (animal Equine/Horse Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Equine disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-EQU-sTREM2-Ag01Equine sTREM2$3090.00
GMP-EQU-sTREM2-Ab01Anti-Equine sTREM2 mouse monoclonal antibody (mAb)$3090.00
GMP-EQU-sTREM2-Ab02Anti-Equine sTREM2 mouse monoclonal antibody (mAb)$3090.00
GMP-EQU-sTREM2-Ab03Anti-Equine sTREM2 human monoclonal antibody (mAb)$3090.00
GMP-EQU-sTREM2-Ab04Anti-Equine sTREM2 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-EQU-sTREM2-Ag01
Product NameEquine sTREM2
Target/BiomarkerEquine sTREM2
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Equine sTREM2 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in sTREM2 level test of animal Equine/Horse with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsEquine sTREM2
Product descriptionRecombinant Equine sTREM2 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-EQU-sTREM2-Ab01,GMP-EQU-sTREM2-Ab02
Target/BiomarkerEquine sTREM2
Product NameAnti-Equine sTREM2 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Equine sTREM2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine sTREM2 antibodies in Equine sTREM2 level test of animal Equine/Horse with Alzheimer Disease(AD).
Product descriptionAnti-Equine sTREM2 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine sTREM2 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-EQU-sTREM2-Ab03,GMP-EQU-sTREM2-Ab04
Target/BiomarkerEquine sTREM2
Product NameAnti-Equine sTREM2 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Equine sTREM2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine sTREM2 antibodies in Equine sTREM2 level test of animal Equine/Horse with Alzheimer Disease(AD).
Product descriptionAnti-Equine sTREM2 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Equine Soluble Triggering Receptor Expressed on Myeloid Cells-2 (sTREM2) emerges as a captivating component of the equine immune and central nervous systems. In its soluble form, sTREM2 assumes a distinct identity compared to its membrane-bound counterpart, TREM2. sTREM2 is generated through proteolytic cleavage of the membrane-bound receptor and can be found in the cerebrospinal fluid and bloodstream of horses.

    Structurally, sTREM2 shares a striking resemblance to its membrane-bound counterpart but lacks the transmembrane domain. It retains the extracellular domain responsible for interactions with various ligands and immune cells. This unique structure empowers sTREM2 to exert its functions within the equine body.

    Functionally, sTREM2 plays a central role in modulating immune responses within the central nervous system of horses. Its presence is particularly notable in microglia, specialized immune cells resident in the equine brain. sTREM2 serves as a signaling molecule, influencing the behavior of microglia and other immune cells, especially in the context of neuroinflammation.

    Crucially, sTREM2's role extends beyond immune modulation. Research suggests that sTREM2 is involved in the phagocytic clearance of cellular debris and potentially contributes to the resolution of inflammation in the equine brain. This multifaceted functionality underscores the importance of sTREM2 in maintaining the delicate balance between immune responses and neurological health in horses.



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