Feline Aβ40 antibody and antigen (recombinant protein)

Diagnostic anti-Feline Aβ40 antibodies pairs and antigen for animal health (animal Cat/Feline Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Companion Animal disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-FEL-AB40-Ag01Feline Aβ40$3090.00
GMP-FEL-AB40-Ab01Anti-Feline Aβ40 mouse monoclonal antibody (mAb)$3090.00
GMP-FEL-AB40-Ab02Anti-Feline Aβ40 mouse monoclonal antibody (mAb)$3090.00
GMP-FEL-AB40-Ab03Anti-Feline Aβ40 human monoclonal antibody (mAb)$3090.00
GMP-FEL-AB40-Ab04Anti-Feline Aβ40 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-FEL-AB40-Ag01
Product NameFeline Aβ40
Target/BiomarkerFeline Aβ40
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Feline Aβ40 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Aβ40 level test of animal Cat/Feline with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsFeline Aβ40
Product descriptionRecombinant Feline Aβ40 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-FEL-AB40-Ab01,GMP-FEL-AB40-Ab02
Target/BiomarkerFeline Aβ40
Product NameAnti-Feline Aβ40 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Feline Aβ40 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline Aβ40 antibodies in Feline Aβ40 level test of animal Cat/Feline with Alzheimer Disease(AD).
Product descriptionAnti-Feline Aβ40 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline Aβ40 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-FEL-AB40-Ab03,GMP-FEL-AB40-Ab04
Target/BiomarkerFeline Aβ40
Product NameAnti-Feline Aβ40 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Feline Aβ40 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline Aβ40 antibodies in Feline Aβ40 level test of animal Cat/Feline with Alzheimer Disease(AD).
Product descriptionAnti-Feline Aβ40 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Feline Amyloid-beta 40 (Aβ40) stands as a pivotal molecule in feline neuroscience, assuming a central role in our understanding of neurodegenerative conditions affecting our cherished feline companions. Comprising 40 amino acids, Aβ40 is a fragment of the amyloid precursor protein (APP) and represents a critical component in the formation of amyloid plaques within the feline brain. These plaques, predominantly composed of Aβ40, symbolize cognitive decline in cats, most notably in cases of feline cognitive dysfunction syndrome (FCDS), which shares similarities with Alzheimer's disease in humans.

    The genesis of Aβ40 involves proteolytic cleavage of APP, a process mediated by β-secretase and γ-secretase enzymes. In cats afflicted by FCDS, an imbalance in Aβ40 metabolism and clearance leads to its aggregation, culminating in the accumulation of amyloid plaques. These plaques disrupt normal neural function, contributing substantially to the cognitive deficits and memory impairments observed in affected cats.

    The implications of Aβ40 aggregation extend beyond cognitive deficits. Aβ40 aggregates can trigger neuroinflammatory responses, oxidative stress, and synaptic dysfunction, collectively exacerbating the neurodegenerative processes occurring in cats suffering from FCDS.



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    GDU helps global diagnostic partners in high quality of raw material discovery, development, and application. GDU believes in Protein&antibody Innovation for more reliable diagnostic solutions.