Feline Aβ42 antibody and antigen (recombinant protein)

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Product information

Size： 1mg | 10mg | 100mg

Catalog No.	Description	US $ Price (per mg)	First Order Discount	First Order Discount Price
GMP-FEL-AB42-Ag01	Recombinant Feline Aβ42 protein	3090
GMP-FEL-AB42-Ab01	Anti-Feline Aβ42 mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-FEL-AB42-Ab02	Anti-Feline Aβ42 mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-FEL-AB42-Ab03	Anti-Feline Aβ42 mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-FEL-AB42-Ab04	Anti-Feline Aβ42 mouse monoclonal antibody (mAb)	1953	20%	1562.4

Shipping Costs: $360–$760
Antibodies: $360 Antigens: $760 (Elevated cost due to antigen heterogeneity, post-translational modifications, structural complexity, and specialized handling.)

Product Description

Cat No. of Products	GMP-FEL-AB42-Ag01
Product Name	Recombinant Feline Aβ42 protein
Target/Biomarker	Feline beta-amyloid 42 (AB42)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline beta-amyloid 42 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in AB42 level test of animal Cat/Feline with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Feline Aβ42 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-AB42-Ab01, GMP-FEL-AB42-Ab02, GMP-FEL-AB42-Ab03, GMP-FEL-AB42-Ab04
Product Name	Anti-Feline Aβ42 mouse monoclonal antibody (mAb)
Target/Biomarker	Feline beta-amyloid 42 (AB42)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Anti-Feline beta-amyloid 42 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in AB42 level test of animal Cat/Feline with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Feline Aβ42 mouse monoclonal antibody (mAb) was expressed in CHO - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker information

Feline Amyloid-beta 42 (Aβ42) represents a cornerstone of feline neuroscience, standing as a molecular sentinel in the study of neurodegenerative conditions affecting our cherished feline companions. Structurally, Aβ42 comprises 42 amino acids and is an integral fragment of the amyloid precursor protein (APP). In a physiological context, APP undergoes sequential proteolytic cleavage, involving β-secretase and γ-secretase enzymes, culminating in the generation of various amyloid-beta peptides, including Aβ42. However, the relevance of Aβ42 extends beyond its role as a byproduct of APP metabolism. In the context of cognitive dysfunction in cats, a condition reminiscent of Alzheimer's disease in humans, Aβ42 takes center stage. An aberration in Aβ42 metabolism and clearance within the feline brain leads to its accumulation, ultimately resulting in the formation of amyloid plaques. These plaques, primarily composed of Aβ42, are emblematic of cognitive decline in affected cats. The pathological implications of Aβ42 aggregation are far-reaching. As amyloid plaques accumulate, they disrupt normal synaptic function, trigger neuroinflammatory responses, and promote oxidative stress. These molecular events collectively contribute to the progressive cognitive deficits observed in cats suffering from feline cognitive dysfunction syndrome (FCDS).

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