Feline Aβ42 antibody and antigen (recombinant protein)

Diagnostic anti-Feline Aβ42 antibodies pairs and antigen for animal health (animal Cat/Feline Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Companion Animal disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-FEL-AB42-Ag01Feline Aβ42$3090.00
GMP-FEL-AB42-Ab01Anti-Feline Aβ42 mouse monoclonal antibody (mAb)$3090.00
GMP-FEL-AB42-Ab02Anti-Feline Aβ42 mouse monoclonal antibody (mAb)$3090.00
GMP-FEL-AB42-Ab03Anti-Feline Aβ42 human monoclonal antibody (mAb)$3090.00
GMP-FEL-AB42-Ab04Anti-Feline Aβ42 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-FEL-AB42-Ag01
Product NameFeline Aβ42
Target/BiomarkerFeline Aβ42
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Feline Aβ42 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Aβ42 level test of animal Cat/Feline with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsFeline Aβ42
Product descriptionRecombinant Feline Aβ42 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-FEL-AB42-Ab01,GMP-FEL-AB42-Ab02
Target/BiomarkerFeline Aβ42
Product NameAnti-Feline Aβ42 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Feline Aβ42 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline Aβ42 antibodies in Feline Aβ42 level test of animal Cat/Feline with Alzheimer Disease(AD).
Product descriptionAnti-Feline Aβ42 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline Aβ42 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-FEL-AB42-Ab03,GMP-FEL-AB42-Ab04
Target/BiomarkerFeline Aβ42
Product NameAnti-Feline Aβ42 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Feline Aβ42 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline Aβ42 antibodies in Feline Aβ42 level test of animal Cat/Feline with Alzheimer Disease(AD).
Product descriptionAnti-Feline Aβ42 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Feline Amyloid-beta 42 (Aβ42) represents a cornerstone of feline neuroscience, standing as a molecular sentinel in the study of neurodegenerative conditions affecting our cherished feline companions. Structurally, Aβ42 comprises 42 amino acids and is an integral fragment of the amyloid precursor protein (APP). In a physiological context, APP undergoes sequential proteolytic cleavage, involving β-secretase and γ-secretase enzymes, culminating in the generation of various amyloid-beta peptides, including Aβ42.

    However, the relevance of Aβ42 extends beyond its role as a byproduct of APP metabolism. In the context of cognitive dysfunction in cats, a condition reminiscent of Alzheimer's disease in humans, Aβ42 takes center stage. An aberration in Aβ42 metabolism and clearance within the feline brain leads to its accumulation, ultimately resulting in the formation of amyloid plaques. These plaques, primarily composed of Aβ42, are emblematic of cognitive decline in affected cats.

    The pathological implications of Aβ42 aggregation are far-reaching. As amyloid plaques accumulate, they disrupt normal synaptic function, trigger neuroinflammatory responses, and promote oxidative stress. These molecular events collectively contribute to the progressive cognitive deficits observed in cats suffering from feline cognitive dysfunction syndrome (FCDS).



    About GDU


    GDU

    GDU helps global diagnostic partners in high quality of raw material discovery, development, and application. GDU believes in Protein&antibody Innovation for more reliable diagnostic solutions.