Cat/Feline lactoferrin antibody and antigen (recombinant protein)

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Diagnostic anti-Cat/Feline lactoferrin antibodies pairs and antigen for animal health (animal Cat/Feline Intestinal Health) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Validation Data

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Target/Biomarker Information

Feline lactoferrin, similar to its counterparts in other species, is a multifunctional protein belonging to the transferrin family, known for its iron-binding capacity and involvement in various biological processes crucial for health and disease management in cats. While specific studies on feline lactoferrin might be less prevalent compared to those on human or bovine lactoferrin, the general roles and benefits of lactoferrin can be extrapolated to suggest its importance in feline health based on its known functions in mammals.

Antimicrobial Activity: Lactoferrin exhibits broad-spectrum antimicrobial properties against bacteria, viruses, fungi, and parasites. This activity is primarily attributed to its ability to sequester iron, which is essential for the growth of many pathogens. Furthermore, lactoferrin can directly bind to microbial cell walls, disrupting their integrity and inhibiting their ability to infect host cells. In cats, this could translate to protection against common feline pathogens, contributing to the innate immune defense against infections.

Immune Modulation: Lactoferrin plays a significant role in modulating the immune response. It can enhance the activity of immune cells such as neutrophils, macrophages, and lymphocytes, boosting the cat's overall immune defense mechanisms. Additionally, lactoferrin possesses anti-inflammatory properties, capable of reducing the production of pro-inflammatory cytokines and mitigating inflammatory responses. This dual action of promoting effective immune responses while preventing excessive inflammation is crucial for maintaining feline health, especially in conditions like feline immunodeficiency virus (FIV) infection or feline lower urinary tract disease (FLUTD), where immune modulation and inflammation control are key to management.

Iron Metabolism and Antioxidant Properties: By tightly binding and transporting iron, lactoferrin plays a critical role in regulating iron homeostasis, ensuring adequate iron supply for physiological needs without promoting oxidative stress or microbial growth. Its antioxidant properties further protect cells from damage caused by free radicals, contributing to overall health and potentially reducing the risk of chronic diseases.

Gut Health and Nutrient Absorption: In cats, as in other mammals, lactoferrin can support gut health by promoting the growth of beneficial gut bacteria and enhancing the intestinal barrier function. This effect is particularly beneficial for kittens receiving colostrum, where lactoferrin from the mother's milk supports the development of a healthy gut flora and immune system. For adult cats, maintaining gut health is crucial for nutrient absorption and prevention of gastrointestinal disorders.

Potential Therapeutic Applications: The antimicrobial, anti-inflammatory, and immune-modulating properties of lactoferrin offer potential therapeutic applications in feline medicine. Supplementation with lactoferrin could be explored as an adjunctive treatment for various infectious and inflammatory conditions in cats, aiming to enhance immune function, control inflammation, and support overall health.

In summary, while specific research on feline lactoferrin may be limited, the known functions of lactoferrin in mammals highlight its potential importance in supporting immune function, regulating inflammation and iron metabolism, and maintaining gut health in cats. Further research into feline-specific applications of lactoferrin could unveil new opportunities for enhancing the health and well-being of cats through nutritional and therapeutic strategies.

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