Feline sTREM2 antibody and antigen (recombinant protein)

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Product information

Size： 1mg | 10mg | 100mg

Catalog No.	Description	US $ Price (per mg)	First Order Discount	First Order Discount Price
GMP-FEL-sTREM2-Ag01	Recombinant Feline sTREM2 protein	3090
GMP-FEL-sTREM2-Ab01	Anti-Feline sTREM2 mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-FEL-sTREM2-Ab02	Anti-Feline sTREM2 mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-FEL-sTREM2-Ab03	Anti-Feline sTREM2 mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-FEL-sTREM2-Ab04	Anti-Feline sTREM2 mouse monoclonal antibody (mAb)	1953	20%	1562.4

Shipping Costs: $360–$760
Antibodies: $360 Antigens: $760 (Elevated cost due to antigen heterogeneity, post-translational modifications, structural complexity, and specialized handling.)

Product Description

Cat No. of Products	GMP-FEL-sTREM2-Ag01
Product Name	Recombinant Feline sTREM2 protein
Target/Biomarker	Feline Soluble Fragment Of Triggering Receptor Expressed On Myeloid Cells 2 (sTREM2)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline Soluble Fragment Of Triggering Receptor Expressed On Myeloid Cells 2 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in sTREM2 level test of animal Cat/Feline with Alzheimer Disease(AD).
Tag	His
Products description	Recombinant Feline sTREM2 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-FEL-sTREM2-Ab01, GMP-FEL-sTREM2-Ab02, GMP-FEL-sTREM2-Ab03, GMP-FEL-sTREM2-Ab04
Product Name	Anti-Feline sTREM2 mouse monoclonal antibody (mAb)
Target/Biomarker	Feline Soluble Fragment Of Triggering Receptor Expressed On Myeloid Cells 2 (sTREM2)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Anti-Feline Soluble Fragment Of Triggering Receptor Expressed On Myeloid Cells 2 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in sTREM2 level test of animal Cat/Feline with Alzheimer Disease(AD).
Tag	mFc
Products description	Anti-Feline sTREM2 mouse monoclonal antibody (mAb) was expressed in CHO - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker information

Feline Soluble Triggering Receptor Expressed on Myeloid Cells-2 (sTREM2) represents a captivating component of the feline immune and central nervous systems. In its soluble form, sTREM2 stands as a distinct entity compared to its membrane-bound counterpart, TREM2. sTREM2 is generated through proteolytic cleavage of the membrane-bound receptor and can be found in the cerebrospinal fluid and bloodstream of cats. Structurally, sTREM2 shares a structural resemblance with its membrane-bound counterpart but lacks the transmembrane domain. It retains the extracellular domain responsible for interactions with various ligands and immune cells. This unique structure equips sTREM2 with the ability to exert its functions within the feline body. Functionally, sTREM2 plays a pivotal role in modulating immune responses within the central nervous system of cats. Its presence is particularly pronounced in microglia, specialized immune cells resident in the brain. sTREM2 acts as a signaling molecule, influencing the behavior of microglia and other immune cells, especially in the context of neuroinflammation. Importantly, sTREM2's role goes beyond immune modulation. Research suggests that sTREM2 is involved in the phagocytic clearance of cellular debris and potentially contributes to the resolution of inflammation in the feline brain. This multifaceted functionality underscores the significance of sTREM2 in maintaining the delicate balance between immune responses and neurological health in cats.

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