Parvalbumin(PVA) antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Parvalbumin(PVA) antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Parvalbumin(PVA)

OVA-Parvalbumin(PVA)

Anti-Parvalbumin(PVA) mouse monoclonal antibody

Anti-Parvalbumin(PVA) human monoclonal antibody

Reference

Validation Data

Click to get more Data / Case study about the product.

Biomarker Information

Parvalbumin (PVA) and its Role in Allergens:

1.1 Parvalbumin Structure and Prevalence (1):

Parvalbumin, often abbreviated as PVA, is a low molecular weight, calcium-binding protein that is predominantly found in the muscle tissues of various fish species. It belongs to the EF-hand superfamily of proteins and plays a pivotal role in muscle contraction. Parvalbumin's unique structure enables it to bind calcium ions efficiently, facilitating rapid muscle contraction and relaxation in fish.

1.2 Allergenicity in Fish (2):

Within the realm of allergens, Parvalbumin emerges as a key player, particularly in the context of fish allergies. Fish allergies are among the most common food allergies globally, affecting a significant portion of the population. When individuals with fish allergies consume fish or products derived from fish containing PVA, their immune systems may perceive this protein as a threat.

1.3 Immune Response Trigger (3):

The immune response triggered by Parvalbumin in sensitized individuals is central to its role as an allergen. Upon exposure to PVA, the immune system recognizes it as an allergenic protein. This recognition sets off a cascade of immunological reactions, including the release of histamines, cytokines, and other inflammatory mediators.

1.4 Allergic Manifestations (4):

The consequences of this immune activation can manifest as a range of allergic symptoms, varying in severity. These symptoms may include localized itching, swelling, hives, gastrointestinal discomfort, difficulty breathing, and in severe cases, anaphylaxis—a potentially life-threatening allergic reaction.

1.5 Importance in Allergen Management (5):

Parvalbumin's significance in allergens is profound. It serves as a crucial marker for the presence of allergenic proteins in fish and fish-derived products. Understanding the prevalence and concentration of PVA in food items is imperative for individuals with fish allergies and healthcare professionals. It allows for accurate allergen labeling, enabling consumers to make informed choices and mitigate the risk of accidental allergen exposure.

Significance of Measuring Parvalbumin (PVA):

2.1 Precise Allergen Labeling (6):

One of the primary reasons for measuring Parvalbumin (PVA) content in food products is to ensure precise allergen labeling. Regulatory agencies worldwide have stringent requirements in place to protect individuals with food allergies. Accurate quantification of PVA content enables food manufacturers to comply with these labeling standards, guaranteeing that products clearly communicate potential allergens to consumers.

2.2 Quality Assurance (7):

In addition to regulatory compliance, monitoring PVA levels is essential for quality assurance within the biopharmaceutical and food production sectors. Consistency in PVA content is paramount for maintaining product quality and safety. This is particularly important for companies producing allergen-free or low-allergen products, as variations in PVA levels could pose risks to consumers with fish allergies.

2.3 Advancement of Research (8):

The scientific community relies on accurate measurements of PVA to further our understanding of fish allergies and allergens in general. Research in this field contributes to the development of improved diagnostic tools, therapeutic interventions, and allergen-specific immunotherapy. By quantifying PVA, researchers can better characterize its immunological properties and explore potential strategies for mitigating allergic reactions.

2.4 Innovation in Product Development (9):

Companies specializing in allergy-related products, such as diagnostic kits, vaccines, or allergy treatments, benefit significantly from precise PVA measurement. This data informs the development and testing of products, ensuring their efficacy in managing fish allergies. It also contributes to the creation of innovative solutions aimed at improving the lives of individuals with fish allergies.

In summary, Parvalbumin (PVA) stands as a critical component in understanding fish allergens and their implications for public health. Its unique properties, prevalence in fish, and role in triggering allergic responses make it a focal point for allergen management. Measuring PVA is essential for precise allergen labeling, quality assurance, scientific research, and the development of innovative products aimed at enhancing the management of fish-related allergens in both the biopharmaceutical and food industries.

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