Amantadine(AM) antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Amantadine(AM) antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Amantadine(AM)

OVA-Amantadine(AM)

Anti-Amantadine(AM) mouse monoclonal antibody

Anti-Amantadine(AM) human monoclonal antibody

Reference

Data / case study

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Biomarker Information

1. Amantadine (AM) and Its Role in In Vitro Diagnosis:

Amantadine (AM), classified as an adamantane derivative, plays a pivotal role in the domain of in vitro diagnosis, with particular prominence in virology and clinical chemistry. As an essential pharmacological compound, AM is renowned for its potent antiviral properties, primarily targeting influenza A viruses. This notoriety is attributed to its mechanism of action, which centers on the inhibition of the M2 ion channel protein, thus impeding the release of viral genetic material into host cells.

Within the realm of in vitro diagnosis, AM assumes multifaceted importance, especially in virology laboratories. Its application is geared towards the precise detection and quantification of influenza A virus in clinical specimens. Various diagnostic methodologies, such as enzyme-linked immunosorbent assays (ELISA) and polymerase chain reaction (PCR), frequently integrate AM as a critical component. This integration serves as a linchpin for early disease diagnosis, epidemiological surveillance, and the vigilant monitoring of influenza outbreaks.

Expanding on the mechanisms at play, AM's antiviral action revolves around its ability to prevent the acidification of endosomes within host cells, a process vital for the successful replication of influenza A viruses. By blocking the M2 ion channel, AM effectively halts the release of viral RNA into the host cell's cytoplasm, thereby inhibiting viral replication and spread.

Furthermore, AM's significance extends beyond its role as an antiviral agent. It also finds utility as a key tool in the precise identification of influenza A strains, enabling clinicians and researchers to differentiate between seasonal and potentially pandemic strains. This level of discrimination is crucial for formulating appropriate therapeutic strategies and ensuring the effectiveness of vaccines.

2. The Significance of Measuring Amantadine (AM):

a. Influenza Diagnosis: Measuring AM holds profound significance in the realm of accurate influenza diagnosis, particularly for infections caused by influenza A viruses. It functions as a discerning marker, aiding in the unequivocal identification of the virus and its virulence. This, in turn, enables healthcare providers to distinguish influenza A from other respiratory ailments, thus facilitating prompt and targeted treatment.

b. Treatment Efficacy: In clinical settings, the quantification of AM assumes a pivotal role in gauging the effectiveness of antiviral treatment regimens, particularly those employing AM-based therapies. AM measurement provides a real-time assessment of patient responsiveness to these treatments, ensuring that prescribed therapeutic interventions effectively combat the influenza A virus.

c. Surveillance and Epidemiology: The meticulous measurement of AM is instrumental in epidemiological investigations and influenza surveillance programs. By systematically monitoring AM levels, healthcare authorities and researchers gain valuable insights into the prevalence and distribution of diverse influenza A strains. This data is indispensable for understanding the dynamics of influenza outbreaks, facilitating the formulation of robust prevention and control strategies, and enhancing preparedness for potential pandemics.

d. Research and Drug Development: AM quantification stands as a cornerstone in virology research and pharmaceutical drug development initiatives. It is an indispensable tool for evaluating the susceptibility of various influenza A strains to antiviral agents, including AM itself. Researchers utilize AM measurements to investigate mechanisms of drug resistance, thereby contributing to the innovation of novel therapeutic modalities and the development of more effective antiviral drugs.

e. Occupational Safety: In laboratory settings where potential exposure to influenza A viruses exists, the assessment of AM levels may form an integral component of safety protocols. By verifying the efficacy of containment measures and ensuring the safety of laboratory personnel, AM measurement plays a vital role in safeguarding occupational health.

In summation, the meticulous measurement of Amantadine (AM) transcends mere analytical endeavor; it embodies multifaceted implications within the ambit of in vitro diagnosis. AM augments the precision of disease diagnosis, enables treatment assessment, empowers epidemiological surveillance, fosters scientific research, and enhances occupational safety. Ultimately, AM measurement contributes significantly to public health protection and scientific progress, particularly in the context of influenza A virus detection and clinical management.

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