Growth hormone (hGH) antibody and antigen (hapten, BSA/OVA conjugated)

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Diagnostic anti-Growth hormone (hGH) antibodies (anti-Growth hormone, anti-hGH) and diagnostic hapten-carrier conjugates BSA-Growth hormone (hGH), OVA-Growth hormone (hGH), KLH-Growth hormone (hGH) antigens for Metabolic diseases hGH detection in ELISA test, competitive ELISA, Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT.

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Growth hormone (hGH)

OVA-Growth hormone (hGH)

Anti-human Growth hormone (hGH) mouse monoclonal antibody (mAb)

Anti-human Growth hormone (hGH) human monoclonal antibody (mAb)

Reference

Validation Data

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Target/Biomarker information

1. What is Growth hormone, and what is its role in in vitro diagnosis (IVD)?

Growth hormone, also known as somatotropin, is a pivotal peptide hormone produced and secreted by the anterior pituitary gland, a small but crucial organ located at the base of the brain. This hormone plays a central role in regulating various physiological processes within the human body. One of its primary functions is to orchestrate the growth and development of tissues, organs, and skeletal structures during childhood and adolescence.

The mechanism of action of Growth hormone is mediated through the stimulation of insulin-like growth factor 1 (IGF-1) production in the liver and other tissues. IGF-1, in turn, promotes cell growth, differentiation, and multiplication, leading to an increase in the size and number of cells in various body tissues. This effect is particularly pronounced in the growth plates of long bones, where Growth hormone stimulates the proliferation of chondrocytes, facilitating longitudinal bone growth.

In addition to its role in growth, Growth hormone exerts significant influence over metabolism, contributing to the regulation of glucose homeostasis, lipid metabolism, and overall energy balance. It promotes lipolysis (breakdown of fats) and enhances the utilization of fatty acids for energy production while conserving glucose for essential cellular functions. This metabolic effect helps to spare glucose and maintain stable blood sugar levels during periods of fasting.

Within the context of in vitro diagnosis (IVD), the measurement of Growth hormone levels in biological samples is of paramount importance. IVD tests designed to quantify Growth hormone concentrations within serum or plasma samples serve as indispensable tools for monitoring endocrine function and diagnosing disorders related to growth and metabolism.

2. Why measure Growth hormone?

The measurement of Growth hormone is critical for several compelling reasons:

a. Detection of Growth-Related Disorders: Growth hormone testing is instrumental in identifying and diagnosing growth-related disorders. Growth hormone deficiency (GHD) is a condition characterized by inadequate production and secretion of Growth hormone, resulting in stunted growth and developmental delays in children. Similarly, excessive Growth hormone secretion can lead to acromegaly in adults and gigantism in children, characterized by abnormal growth of tissues and organs. Timely diagnosis and intervention are essential for managing these conditions effectively.

b. Monitoring Growth Hormone Replacement Therapy: Individuals diagnosed with GHD often require Growth hormone replacement therapy to promote normal growth and development. Regular monitoring of Growth hormone levels is essential to ensure the therapy's effectiveness and to make necessary adjustments in dosage to achieve optimal growth outcomes.

c. Advancing Scientific Knowledge: Growth hormone measurements are invaluable for research studies exploring growth, metabolic processes, and the underlying mechanisms of related disorders. These measurements provide critical data essential for unraveling the intricate signaling pathways and molecular interactions involved in growth regulation. Additionally, they contribute to the development of targeted therapeutic strategies for individuals with Growth hormone-related disorders.

d. Anti-Doping Measures: In the realm of sports medicine and competitive athletics, Growth hormone testing serves as a vital tool for detecting doping violations. Athletes may misuse Growth hormone to enhance physical performance, and anti-doping authorities rely on accurate measurements to maintain fairness in sports competitions.

e. Comprehensive Pituitary Assessment: Growth hormone testing is an integral component of comprehensive assessments aimed at evaluating pituitary gland function. The pituitary gland is a master endocrine organ that governs the release of multiple hormones, including Growth hormone. Aberrations in pituitary function can have far-reaching consequences, impacting various endocrine processes. By including Growth hormone measurements in pituitary evaluations, healthcare professionals can diagnose a range of endocrine disorders and initiate appropriate treatments.

In summary, the measurement of Growth hormone through IVD procedures is indispensable for the diagnosis and management of growth-related disorders, the monitoring of treatment efficacy, the advancement of medical research, the prevention of doping in sports, and the comprehensive evaluation of pituitary gland function. This diagnostic tool not only enhances healthcare outcomes but also contributes to an enriched understanding of growth and metabolism, serving as a cornerstone in both clinical and research settings.

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