Picture loading failed.

Description of Small molecules (Chemicals, Antibiotics,Mycotoxins,Hormones,Drugs of Abuse, etc.)

Tolfenamic Acid is an orally available, benzoic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic, analgesic and potential anti-neoplastic activities. Tolfenamic acid inhibits the activity of the enzymes cyclooxygenase (COX) I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The decrease in prostaglandin synthesis results in the therapeutic effects of this agent. Tolfenamic acid also inhibits thromboxane A2 synthesis, by thromboxane synthase, which decreases platelet aggregation. In addition, this agent exerts anti-tumor effects through COX-dependent and independent pathways. Specifically, this agent induces the production of reactive oxygen species, causes DNA damage, increases nuclear factor-kappa B (NF-kB) activation and the expression of activating transcription factor 3 (ATF3) and NSAID-activated gene-1 (NAG1), and inhibits the expression of specificity proteins (Sp), which reduces the expression of Sp-dependent anti-apoptotic and growth-promoting proteins. Altogether, this enhances tumor cell apoptosis, and reduces tumor cell growth and angiogenesis.

Tolfenamic acid is an aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor and an EC 2.7.1.33 (pantothenate kinase) inhibitor. It is an aminobenzoic acid, an organochlorine compound and a secondary amino compound. It derives from an anthranilic acid.

Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent. It was discovered by scientists at Medica Pharmaceutical Company in Finland. It is used in the UK as a treatment for migraine under the name of Clotam. In the US, it presents a Status class I by the FDA. By the European Medicine Agency, it was granted in 2016 with the status of orphan for the treatment of supranuclear palsy.

Order informatioin


Delivery impact due to the Coronavirus Outbreak

With the COVID-19 outbreak in the world, many flights have been cancelled. In order for the customer to receive the goods properly, we use the FedEx Customized Freight (FCF) of Fedex which demands a higher fee. If the delivery fee is more expensive in your area, we will contact you by mail.

Catalog No. Description Price(In USD) Qty (Quantity) Sum(In USD)
GMP-SMT-197-1 1. BSA-Tolfenamicacid; Size:1mg
2. Anti-Tolfenamicacid mouse monoclonal antibody; Size:1mg
1365
GMP-SMT-197-1 1. BSA-Tolfenamicacid; Size:10mg
2. Anti-Tolfenamicacid mouse monoclonal antibody; Size:10mg
8232
GMP-SMT-197-1 1. BSA-Tolfenamicacid; Size:100mg
2. Anti-Tolfenamicacid mouse monoclonal antibody; Size:100mg
41160
GMP-SMT-197-2 1. OVA-Tolfenamicacid; Size:1mg
2. Anti-Tolfenamicacid mouse monoclonal antibody; Size:1mg
1365
GMP-SMT-197-2 1. OVA-Tolfenamicacid; Size:10mg
2. Anti-Tolfenamicacid mouse monoclonal antibody; Size:10mg
8232
GMP-SMT-197-2 1. OVA-Tolfenamicacid; Size:100mg
2. Anti-Tolfenamicacid mouse monoclonal antibody; Size:100mg
41160
GMP-SMT-197-Ab-1 Anti-Tolfenamicacid mouse monoclonal antibody; Size:1mg 1043
GMP-SMT-197-Ab-1 Anti-Tolfenamicacid mouse monoclonal antibody; Size:10mg 6272
GMP-SMT-197-Ab-1 Anti-Tolfenamicacid mouse monoclonal antibody; Size:100mg 31360
GMP-SMT-197-Ag-1 BSA-Tolfenamicacid; Size:1mg 756
GMP-SMT-197-Ag-1 BSA-Tolfenamicacid; Size:10mg 4536
GMP-SMT-197-Ag-1 BSA-Tolfenamicacid; Size:100mg 22960
GMP-SMT-197-Ag-2 OVA-Tolfenamicacid; Size:1mg 756
GMP-SMT-197-Ag-2 OVA-Tolfenamicacid; Size:10mg 4536
GMP-SMT-197-Ag-2 OVA-Tolfenamicacid; Size:100mg 22960
GMP-SMT-197 ≥100mg Inquiry
Shipping Cost: 760.00
Total:



Description


BSA-Tolfenamicacid

Cat No. GMP-SMT-197-Ag-1
Bioactivity validation Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Products description Competitive immunoassay-validated hapten-carrier conjugates [BSA-Tolfenamicacid)]with anti-Hapten antibody. The hapten hapten-carrier conjugates [BSA-Tolfenamicacid)] had been validated with our anti-Hapten antibody[Anti-Tolfenamicacid mouse monoclonal antibody] via competitive ELISA test.
Application ELISA tests and other immunoassays;
Lateral flow immunoassay (LFIA);
LTIA
Immunonephelometry
Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


OVA-Tolfenamicacid

Cat No. GMP-SMT-197-Ag-2
Bioactivity validation Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Products description Competitive immunoassay-validated hapten-carrier conjugates [ OVA-Tolfenamicacid)] with anti-Hapten antibody. The hapten hapten-carrier conjugates[ OVA-Tolfenamicacid)] had been validated with our anti-Hapten antibody[Anti-Tolfenamicacid mouse monoclonal antibody] via competitive ELISA test.
Application ELISA tests and other immunoassays;
Lateral flow immunoassay (LFIA);
LTIA
Immunonephelometry
Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Anti-Tolfenamicacid mouse monoclonal antibody

Cat No. GMP-SMT-197-Ab-1
Host of Antibody Mouse IgG
Bioactivity validation Competitive immunoassay validation (Competitive ELISA) with hapten-carrier conjugates and anti-Hapten antibody;
Lateral flow immunoassay (LFIA);
ELISA IC50 (ppb) 2
Products description The anti-Hapten antibody against hapten [Tolfenamicacid)] had beenvalidated with our hapten hapten-carrier conjugates [BSA-Tolfenamicacid)] via competitive ELISA test.
Application ELISA tests and other immunoassays;
Lateral flow immunoassay (LFIA);
LTIA
Immunonephelometry
Time-resolved Fluorescence Immunoassay (TRFIA)
Formulation Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.