Tolfenamicacid antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Tolfenamicacid antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Tolfenamicacid

OVA-Tolfenamicacid

Anti-Tolfenamicacid mouse monoclonal antibody

Anti-Tolfenamicacid human monoclonal antibody

Reference

Data / case study

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Biomarker Information

1. Tolfenamic Acid:

Tolfenamic acid, chemically identified as 2-[(3-chloro-2-methylphenyl)amino]benzoic acid, is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the carboxylic acid derivatives class of compounds. Its distinct chemical structure is characterized by a phenyl ring substituted with both a chlorine atom and a methyl group, rendering it a potent pharmacological agent with specific therapeutic attributes. Tolfenamic acid exhibits anti-inflammatory, analgesic, and antipyretic properties, making it a valuable component in various medical applications.

Role in In Vitro Diagnosis (IVD):

Tolfenamic acid's versatile properties have found a niche in the field of in vitro diagnosis (IVD). Its role in IVD revolves around its capability to serve as a competitive antigen or immunogen when conjugated with carrier proteins, such as BSA (Bovine Serum Albumin) or OVA (Ovalbumin). This conjugation is fundamental for the development of specific antibodies that play pivotal roles in diverse diagnostic scenarios.

a. Immunoassays: Tolfenamic acid-conjugated antigens are integral components of immunoassays, particularly in widely employed techniques like ELISA (Enzyme-Linked Immunosorbent Assay). These conjugates are instrumental in detecting and quantifying specific analytes within biological samples with exceptional precision. By leveraging Tolfenamic acid's unique chemical structure, these immunoassays can achieve high sensitivity and specificity, ensuring accurate diagnoses in a clinical setting.

b. Biomarker Research: In the realm of biomarker research, Tolfenamic acid conjugates facilitate the meticulous study of specific biomarkers or drug compounds. Researchers utilize these conjugates to enable precise detection and quantification of the presence or concentration of target molecules. This capability is invaluable for advancing our understanding of various diseases and their associated biomarkers, aiding in the development of diagnostic tools and potential therapeutic interventions.

c. Disease Diagnosis: Tolfenamic acid derivatives may serve as reference compounds in specific diagnostic tests and assays. These derivatives ensure the reliability and accuracy of diagnostic procedures by offering a known standard against which test results can be compared. This quality control aspect is crucial for enhancing the overall performance and confidence in diagnostic methods.

In summation, Tolfenamic acid's role in IVD underscores its significance as a versatile tool for generating antibodies and antigens. This capability allows for the precise and targeted detection and measurement of specific molecules of interest, thereby contributing to the advancement of diagnostics and medical research.

2. Why Measure Tolfenamic Acid:

The measurement of Tolfenamic acid is integral to various scientific, clinical, and pharmaceutical endeavors due to its multifaceted importance:

a. Drug Development: Tolfenamic acid holds potential as both a candidate drug and an active ingredient in pharmaceutical formulations. The precise measurement of its concentration is paramount during drug development to ensure that it falls within predetermined specifications. This ensures not only the safety of the drug but also its efficacy in treating the intended medical conditions. Accurate measurements guide the formulation process, facilitating the creation of pharmaceutical products with consistent quality and therapeutic effects.

b. Therapeutic Monitoring: In the clinical context, patients receiving medications containing Tolfenamic acid necessitate ongoing monitoring. Monitoring involves the measurement of Tolfenamic acid levels in biological samples, such as blood or urine. This process aids healthcare professionals in optimizing dosages to achieve the desired therapeutic outcomes while mitigating potential side effects. Therapeutic monitoring is particularly crucial in chronic conditions where medication dosage adjustments may be required over time.

c. Research and Biomarker Studies: Tolfenamic acid often serves as a reference compound or marker in various research studies. Its unique chemical structure makes it a suitable candidate for validating research findings and maintaining data integrity. Researchers employ Tolfenamic acid as a benchmark in experiments aimed at studying the effects of different drugs or assessing the presence of specific biomarkers. Accurate measurements of Tolfenamic acid ensure the reliability of research results, contributing to the advancement of scientific knowledge.

d. Quality Control: Within the realm of pharmaceutical manufacturing, meticulous measurement of Tolfenamic acid content is fundamental to ensuring the consistency and quality of drug products. Stringent quality control measures are essential to meet regulatory standards and deliver safe and effective medications to patients. Accurate measurements of Tolfenamic acid content at various stages of manufacturing help identify deviations and ensure that products adhere to established specifications.

e. Toxicology Studies: Tolfenamic acid level measurements in biological specimens play a pivotal role in identifying any adverse effects associated with its use. Toxicology studies are essential for evaluating the safety profile of Tolfenamic acid-containing medications. Accurate measurements assist in detecting and quantifying potential toxic effects, informing decisions regarding dosage adjustments, safety precautions, and risk assessment.

In summary, the precise measurement of Tolfenamic acid is fundamental to ensuring the safety and efficacy of pharmaceutical products, advancing scientific research, upholding pharmaceutical quality control standards, optimizing clinical practices, and safeguarding patient well-being. Its multifaceted importance underscores the need for accurate and reliable measurement techniques in various scientific and clinical settings.

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