Antipyrine(AP) antibody and antigen (hapten, BSA/OVA conjugated)

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Diagnostic anti-Antipyrine (AP) antibodies (anti-Antipyrine, anti-AP) and diagnostic hapten-carrier conjugates BSA-Antipyrine (AP), OVA-Antipyrine (AP), KLH-Antipyrine (AP) antigens for Liver diseases AP detection in ELISA test, competitive ELISA, Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT.

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Antipyrine(AP)

OVA-Antipyrine(AP)

Anti-human Antipyrine(AP) mouse monoclonal antibody (mAb)

Anti-human Antipyrine(AP) human monoclonal antibody (mAb)

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker information

1. Antipyrine and Its Significance in Pharmacokinetic and Liver Function Assessment

Antipyrine (Phenazone) is a synthetic compound with antipyretic and analgesic properties, recognized for its historical and ongoing utility in pharmacological research and diagnostics. Although its direct application in treating fever and pain has been superseded by newer, more effective medications, Antipyrine retains a pivotal role in the in vitro diagnostics (IVD) domain, particularly in evaluating metabolic processes and liver function.

Antipyrine's metabolism in the human body is mediated predominantly by the cytochrome P450 enzyme system, a crucial set of enzymes involved in the oxidative metabolism of drugs. The liver, being the central organ for drug metabolism, processes Antipyrine in a manner that reflects its overall health and functional capacity. Thus, the analysis of Antipyrine metabolism serves as an indirect yet highly informative method for assessing hepatic function and the enzymatic activity of cytochrome P450.

2. Clinical and Research Applications of Antipyrine Measurement

The measurement of Antipyrine is instrumental for several critical applications in clinical diagnostics, therapeutic drug monitoring, and pharmacokinetic research:

Evaluating Hepatic Function: By monitoring how quickly and efficiently Antipyrine is metabolized and cleared from the body, healthcare professionals can gain insights into the liver's functional state. This assessment is particularly vital for diagnosing liver diseases, monitoring the progression of hepatic dysfunction, and understanding the impact of liver disease on drug metabolism.

Understanding Drug-Drug Interactions: Antipyrine's metabolism can be affected by other drugs that induce or inhibit the cytochrome P450 enzymes. Studying these interactions through Antipyrine metabolism helps predict how other medications might interact within the body, guiding the safe and effective use of combination therapies.

Facilitating Personalized Medicine: Variability in Antipyrine metabolism among individuals can inform personalized treatment strategies. By adjusting medication dosages based on metabolic rates, clinicians can optimize therapeutic efficacy and minimize the risk of adverse drug reactions, moving closer to personalized healthcare.

Advancing Pharmacokinetic Research: In the development of new pharmaceuticals, Antipyrine serves as a reference compound for studying the absorption, distribution, metabolism, and excretion (ADME) of drugs. Its straightforward metabolic pathway makes it an ideal model for understanding the pharmacokinetic profiles of new compounds, contributing to safer and more effective drug design.

Investigating Metabolic Enzyme Activity: The study of Antipyrine metabolism is also key to researching the activity of specific metabolic enzymes within the cytochrome P450 system. This research has broader implications for understanding genetic variations in metabolism, the development of metabolic disorders, and the identification of potential targets for drug therapy.

3. Methodologies for Measuring Antipyrine

To accurately measure Antipyrine levels and its metabolites in biological samples, sophisticated analytical techniques are employed. These include high-performance liquid chromatography (HPLC), mass spectrometry (MS), and combined approaches like LC-MS/MS. These methodologies provide the sensitivity, specificity, and quantitative accuracy required for effective therapeutic monitoring, drug interaction studies, and pharmacokinetic analysis.

In summary, Antipyrine's role in in vitro diagnostics and pharmacological research underscores its enduring value in medical science. By facilitating the assessment of liver function, enabling the study of drug-drug interactions, supporting personalized medicine, and advancing pharmacokinetic research, Antipyrine contributes significantly to the optimization of therapeutic strategies and the development of new medications, enhancing patient care and safety in clinical practice.

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