Vitamin B12 (Vb12) antibody and antigen (hapten, BSA/OVA conjugated)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-SMT-217-Ag01	BSA-Vitamin B12 (Vb12)	756
GMP-SMT-217-Ag02	OVA-Vitamin B12 (Vb12)	756
GMP-SMT-217-Ab01	Anti-human Vitamin B12 (Vb12) mouse monoclonal antibody (mAb)	1953
GMP-SMT-217-Ab02	Anti-human Vitamin B12 (Vb12) human monoclonal antibody (mAb)	1953

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-SMT-217-Ag01
Product Name	BSA-Vitamin B12 (Vb12)
Target/Biomarker	Vitamin B12 (Vb12)
Expression platform	Synthetic
Isotypes	NA
Bioactivity validation	Vitamin B12 (Vb12) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Vb12 level test of Vitamin deficiency (Vitamin B12 deficiency) and related syndrome evaluation.
Tag	NA
Products description	Competitive immunoassay-validated hapten-carrier conjugates BSA-Vitamin B12 (Vb12) / OVA-Vitamin B12 (Vb12) is Synthetic.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Competitive immunoassay validation (Competitive ELISA), ELISA, Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-SMT-217-Ag02
Product Name	OVA-Vitamin B12 (Vb12)
Target/Biomarker	Vitamin B12 (Vb12)
Expression platform	Synthetic
Isotypes	NA
Bioactivity validation	Vitamin B12 (Vb12) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Vb12 level test of Vitamin deficiency (Vitamin B12 deficiency) and related syndrome evaluation.
Tag	NA
Products description	Competitive immunoassay-validated hapten-carrier conjugates BSA-Vitamin B12 (Vb12) / OVA-Vitamin B12 (Vb12) is Synthetic.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Competitive immunoassay validation (Competitive ELISA), ELISA, Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-SMT-217-Ab01
Product Name	Anti-human Vitamin B12 (Vb12) mouse monoclonal antibody (mAb)
Target/Biomarker	Vitamin B12 (Vb12)
Expression platform	Hybridoma
Isotypes	Mouse IgG
Bioactivity validation	Vitamin B12 (Vb12) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Vb12 level test of Vitamin deficiency (Vitamin B12 deficiency) and related syndrome evaluation.
Tag	mFc
Products description	Competitive immunoassay-validated hapten-carrier conjugates BSA-Vitamin B12 (Vb12) / OVA-Vitamin B12 (Vb12) is Synthetic.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Competitive immunoassay validation (Competitive ELISA),Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-SMT-217-Ab02
Product Name	Anti-human Vitamin B12 (Vb12) human monoclonal antibody (mAb)
Target/Biomarker	Vitamin B12 (Vb12)
Expression platform	Hybridoma
Isotypes	Mouse IgG
Bioactivity validation	Vitamin B12 (Vb12) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Vb12 level test of Vitamin deficiency (Vitamin B12 deficiency) and related syndrome evaluation.
Tag	mFc
Products description	Competitive immunoassay-validated hapten-carrier conjugates BSA-Vitamin B12 (Vb12) / OVA-Vitamin B12 (Vb12) is Synthetic.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Competitive immunoassay validation (Competitive ELISA),Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

1. Detailed Overview of Cobalamin (Vitamin B12) and Its Diagnostic Importance: Cobalamin (Vitamin B12) is a water-soluble vitamin essential for human health, playing a pivotal role in red blood cell formation, neurological function, and DNA synthesis. This crucial nutrient, containing a metal ion, cobalt, is involved in various metabolic pathways, including the synthesis of methionine from homocysteine and the conversion of methylmalonyl-CoA to succinyl-CoA. Vitamin B12 deficiency can lead to severe hematological and neurological disorders, making its detection and quantification vital in clinical diagnostics. In the realm of in vitro diagnostics (IVD), the accurate measurement of Vitamin B12 levels is paramount for diagnosing conditions such as megaloblastic anemia and pernicious anemia, as well as assessing the risk and presence of neuropathy and cognitive impairments associated with B12 deficiency. Advanced diagnostic assays, empowered by high-affinity anti-Vitamin B12 antibodies and competitive antigens, are essential for the sensitive and specific detection of Vitamin B12 in patient samples. These IVD assays facilitate the early identification of deficiencies, enabling timely and effective treatment interventions. 2. The Clinical Imperatives for Quantitative Vitamin B12 Analysis: The clinical necessity for precise Vitamin B12 measurement extends beyond the diagnosis of deficiency-related anemias to encompass a broader spectrum of health assessments and therapeutic monitoring. Vitamin B12 levels are indicative of an individual’s metabolic and neurological health, with deficiencies linked to a range of adverse health outcomes, including cardiovascular disease due to elevated homocysteine levels, impaired fetal development during pregnancy, and potential irreversible neurological damage. Regular screening for Vitamin B12 levels is particularly critical in populations at increased risk of deficiency, such as the elderly, individuals with gastrointestinal disorders that impair nutrient absorption (e.g., Crohn’s disease, celiac disease), vegetarians, and vegans. The quantification of Vitamin B12 is also integral to the management of patients undergoing bariatric surgery, where the risk of malabsorption and subsequent deficiency is high. Furthermore, the measurement of Vitamin B12 levels plays a crucial role in the therapeutic monitoring of patients receiving supplementation for documented deficiencies. It ensures that treatment is effective, adjusting dosages as necessary to achieve and maintain optimal Vitamin B12 status, thereby preventing the progression of deficiency symptoms and safeguarding against neurological complications. Our company's contributions to this field, through the provision of specialized IVD reagents, including anti-Vitamin B12 antibodies and competitive antigens, underscore the importance of accurate diagnostic tools in the detection and management of Vitamin B12-related conditions. These reagents are designed for compatibility with a variety of assay formats, including ELISA, chemiluminescence, and more, offering flexibility and precision in Vitamin B12 quantification across diverse clinical settings. By facilitating the development of reliable Vitamin B12 assays, our products support healthcare professionals in diagnosing, monitoring, and treating Vitamin B12 deficiency and its associated health implications. This commitment to advancing in vitro diagnostic capabilities reflects our dedication to improving patient care through science and innovation, contributing significantly to the fields of hematology, neurology, and preventive medicine. This expanded description provides a detailed exploration of Vitamin B12's biological importance, its role in IVD, and the clinical imperatives for its measurement, aimed at a scientific audience and optimized for search engine rankings.

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