Lactoferrin(LF) antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Lactoferrin(LF) antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

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Product Description

BSA-Lactoferrin(LF)

OVA-Lactoferrin(LF)

Anti-Lactoferrin(LF) mouse monoclonal antibody

Anti-Lactoferrin(LF) human monoclonal antibody

Reference

Data / case study

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Biomarker Information

1. Lactoferrin (LF): A Multifunctional Glycoprotein

Lactoferrin (LF) stands as a multifaceted glycoprotein ubiquitous in various biological fluids, exemplifying its presence in milk, saliva, tears, and neutrophil granules1. Belonging to the transferrin protein family, LF is distinguished by its ability to avidly sequester and bind iron, underscoring its fundamental role in iron homeostasis and its designation as a key constituent of the innate immune system12. While LF's iron-binding properties are pivotal, its diverse array of bioactive characteristics bestow it with profound significance across a multitude of biological contexts2.

LF's unique iron-binding capacity is vital for the regulation of iron levels in the body2. By chelating iron, LF plays a dual role: depriving pathogens of essential iron for growth and modulating the body's immune response1. This antimicrobial function of LF has made it a subject of intense research for its potential in combating bacterial, viral, and fungal infections3.

Beyond its iron-related roles, LF exhibits multifaceted bioactivity4. It possesses potent antioxidant properties, helping to neutralize harmful free radicals and mitigate oxidative stress5. Moreover, LF demonstrates anti-inflammatory effects by regulating cytokine production and modulating immune responses6. These properties underscore LF's importance in various physiological and pathological processes.

2. The Significance of Measuring Lactoferrin (LF) in In Vitro Diagnosis (IVD)

1. Infection Surveillance: Lactoferrin serves as a valuable biomarker for the detection of infections and inflammatory conditions7. Its presence in bodily fluids, such as serum, saliva, or tears, plays a crucial role in immune responses against microbial invaders78. Elevated LF concentrations in these fluids often signify the presence of underlying infections or heightened inflammatory responses7.

2. Inflammatory Disease Monitoring: LF emerges as a pivotal biomarker for the monitoring of inflammatory disorders8. In conditions like inflammatory bowel disease (IBD) and rheumatoid arthritis (RA), LF levels in various bodily fluids correlate with disease activity910. Monitoring LF levels enables clinicians to assess disease progression and tailor treatment strategies accordingly9.

3. Gastrointestinal Assessment: Within the realm of gastroenterology, LF measurements hold a special place11. LF levels are particularly useful for evaluating intestinal inflammation and distinguishing between various gastrointestinal pathologies12. This diagnostic utility aids in the timely identification and management of conditions like Crohn's disease and ulcerative colitis12.

4. Neonatal Care: In the context of neonatal care, LF assumes a critical role13. LF levels in breast milk are analyzed to gauge the nutritional and immunological constituents of the milk14. This assessment is especially vital for the well-being of premature infants, as it helps healthcare providers ensure that they receive the necessary nourishment and immunological support for healthy growth and development14.

5. IVD Assays: Lactoferrin's versatility extends to its incorporation into various IVD assays15. These assays are meticulously designed for the diagnosis of specific medical conditions and the monitoring of treatment efficacy15. LF-based assays offer high specificity and sensitivity, making them invaluable tools for healthcare practitioners16.

In summary, Lactoferrin (LF) transcends its role as a simple iron-binding protein, showcasing multifunctional properties that render it pivotal in numerous biological processes4. Its capacity to modulate the immune system, combat infections, and mitigate inflammation positions it as a versatile and indispensable biomarker in the field of in vitro diagnosis (IVD)17. By measuring LF levels in various bodily fluids, healthcare professionals gain profound insights into diverse health conditions, enabling tailored therapeutic interventions and enhancing patient care18.

Footnotes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818066/ ↩ ↩2 ↩3

https://pubmed.ncbi.nlm.nih.gov/29671847/ ↩ ↩2 ↩3

https://pubmed.ncbi.nlm.nih.gov/30039696/ ↩

https://pubmed.ncbi.nlm.nih.gov/29899263/ ↩ ↩2

https://pubmed.ncbi.nlm.nih.gov/29663005/ ↩

https://pubmed.ncbi.nlm.nih.gov/30216799/ ↩

https://pubmed.ncbi.nlm.nih.gov/33574121/ ↩ ↩2 ↩3

https://pubmed.ncbi.nlm.nih.gov/34484886/ ↩ ↩2

https://pubmed.ncbi.nlm.nih.gov/33506303/ ↩ ↩2

https://pubmed.ncbi.nlm.nih.gov/33715217/ ↩

https://pubmed.ncbi.nlm.nih.gov/33534175/ ↩

https://pubmed.ncbi.nlm.nih.gov/33019164/ ↩ ↩2

https://pubmed.ncbi.nlm.nih.gov/33277410/ ↩

https://pubmed.ncbi.nlm.nih.gov/33627584/ ↩ ↩2

https://pubmed.ncbi.nlm.nih.gov/33535308/ ↩ ↩2

https://pubmed.ncbi.nlm.nih.gov/33895657/ ↩

https://pubmed.ncbi.nlm.nih.gov/33758197/ ↩

https://pubmed.ncbi.nlm.nih.gov/33627285/ ↩

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