Canine Coronavirus antibody and antigen (recombinant protein)

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Diagnostic anti-Canine Coronavirus antibodies pairs and antigen for animal health (animal Dog/Canine infectious disease Canine coronavirus (CCoV) - intestinal infection) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P005-Tg001-Ag01	Recombinant Canine Coronavirus protein	$3090.00
GMP-VT-P005-Tg001-Ab01	Anti-Canine Coronavirus mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P005-Tg001-Ab02	Anti-Canine Coronavirus mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P005-Tg001-Ab03	Anti-Canine Coronavirus human monoclonal antibody (mAb)	$3090.00
GMP-VT-P005-Tg001-Ab04	Anti-Canine Coronavirus human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P005-Tg001-Ag01
Product Name	Recombinant Canine Coronavirus protein
Pathogen	Canine Coronavirus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Coronavirus antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Canine Coronavirus level test of animal Dog/Canine infectious disease with Canine coronavirus (CCoV) - intestinal infection.
Tag	His
Product description	Recombinant Canine Coronavirus proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P005-Tg001-Ab01,GMP-VT-P005-Tg001-Ab02
Pathogen	Canine Coronavirus
Product Name	Anti-Canine Coronavirus mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Coronavirus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Coronavirus antibodies in Canine Coronavirus level test of animal Dog/Canine infectious disease with Canine coronavirus (CCoV) - intestinal infection.
Product description	Anti-Canine Coronavirus mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Coronavirus antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P005-Tg001-Ab03,GMP-VT-P005-Tg001-Ab04
Pathogen	Canine Coronavirus
Product Name	Anti-Canine Coronavirus human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Canine Coronavirus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Coronavirus antibodies in Canine Coronavirus level test of animal Dog/Canine infectious disease with Canine coronavirus (CCoV) - intestinal infection.
Product description	Anti-Canine Coronavirus mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Canine Coronavirus (CCoV) is a highly contagious pathogen that primarily targets dogs. The virus was first identified in the late 1970s and has since been documented globally. A study conducted from 2011-2016 reported an overall prevalence rate of 3.6% in dogs worldwide. CCoV infections are most commonly seen in young puppies, elderly dogs, and immunocompromised dogs.

CCoV belongs to the Coronaviridae family, which contains several viruses known to cause disease in both humans and animals. Members of this family are characterized by their positive-sense RNA genome and distinctive club-shaped spikes on the virus surface. Coronaviruses are further classified into four genera, with CCoV falling within the genus Alphacoronavirus.

The virus has a genome that is approximately 30 kilobases in size and encodes for several structural and nonstructural proteins. The structural proteins include the spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins. The S protein is responsible for viral attachment and entry into host cells, while the N protein is involved in genome packaging and viral replication. The M and E proteins are involved in virus assembly and release. Nonstructural proteins include the replicase and other enzymes that aid in viral replication.

CCoV infection in dogs is associated with gastrointestinal disease, characterized by vomiting and diarrhea. The severity of the disease can vary widely, with some cases resulting in fatality. CCoV causes damage to the intestinal lining, leading to malabsorption of nutrients and dehydration. In addition, the virus can also infect immune cells, leading to immunosuppression and increased susceptibility to secondary infections. While other animals, such as foxes and raccoons, may harbor similar viruses, they do not transmit the pathogen to humans.

Diagnosis of CCoV infection can be challenging, as clinical symptoms may resemble those caused by other viral or bacterial pathogens. Diagnostic tests for CCoV include enzyme-linked immunosorbent assays (ELISA) and reverse transcription polymerase chain reaction (RT-PCR) assays that target specific regions of the viral RNA genome. Commonly targeted genes include the S and N genes. In addition to molecular methods, electron microscopy may also be used to visualize viral particles in infected samples.

Prevention and control of CCoV infections rely on strict hygiene practices and vaccination. Effective vaccination can reduce the rate of infection and the severity of disease. Vaccines are available for both CCoV and Canine Parvovirus, another highly contagious gastrointestinal pathogen in dogs. It is important to note that vaccines may not protect against all strains of the virus, and vaccination should be administered under the guidance of a veterinarian.

In conclusion, Canine Coronavirus is a highly contagious pathogen that primarily targets dogs and causes gastrointestinal disease. The virus belongs to the Coronaviridae family and is classified as a positive-sense RNA virus within the genus Alphacoronavirus. Diagnosis of CCoV infection can be challenging, and effective prevention and control rely on strict hygiene practices and vaccination.

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