Canine Adenovirus Type I antibody and antigen (recombinant protein)

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Diagnostic anti-Canine Adenovirus Type I antibodies pairs and antigen for animal health (animal Dog/Canine, Fox, Wolf, Coyote, Skunk, Bear infectious disease Infectious canine hepatitis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P008-Tg001-Ag01	Recombinant Canine Adenovirus Type I protein	$3090.00
GMP-VT-P008-Tg001-Ab01	Anti-Canine Adenovirus Type I mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P008-Tg001-Ab02	Anti-Canine Adenovirus Type I mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P008-Tg001-Ab03	Anti-Canine Adenovirus Type I human monoclonal antibody (mAb)	$3090.00
GMP-VT-P008-Tg001-Ab04	Anti-Canine Adenovirus Type I human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P008-Tg001-Ag01
Product Name	Recombinant Canine Adenovirus Type I protein
Pathogen	Canine Adenovirus Type I
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Adenovirus Type I antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Canine Adenovirus Type I level test of animal Dog/Canine, Fox, Wolf, Coyote, Skunk, Bear infectious disease with Infectious canine hepatitis.
Tag	His
Product description	Recombinant Canine Adenovirus Type I proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P008-Tg001-Ab01,GMP-VT-P008-Tg001-Ab02
Pathogen	Canine Adenovirus Type I
Product Name	Anti-Canine Adenovirus Type I mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine Adenovirus Type I antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Adenovirus Type I antibodies in Canine Adenovirus Type I level test of animal Dog/Canine, Fox, Wolf, Coyote, Skunk, Bear infectious disease with Infectious canine hepatitis.
Product description	Anti-Canine Adenovirus Type I mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Adenovirus Type I antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P008-Tg001-Ab03,GMP-VT-P008-Tg001-Ab04
Pathogen	Canine Adenovirus Type I
Product Name	Anti-Canine Adenovirus Type I human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Canine Adenovirus Type I antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine Adenovirus Type I antibodies in Canine Adenovirus Type I level test of animal Dog/Canine, Fox, Wolf, Coyote, Skunk, Bear infectious disease with Infectious canine hepatitis.
Product description	Anti-Canine Adenovirus Type I mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Canine Adenovirus Type I (CAV-1) is a highly infectious virus that primarily affects dogs. It is one of the two serotypes of Canine Adenovirus, the other being Canine adenovirus type 2 (CAV-2). CAV-1 is a non-enveloped virus with a double-stranded DNA genome, belonging to the family Adenoviridae.

The CAV-1 virus has a unique replication cycle, allowing it to hijack cellular machinery in the host animal's body and use it to produce new viral particles. The main gene responsible for this process is the E1A gene, which initiates viral replication and transcription. These processes are essential for the virus to spread and establish new infections.

The hexon protein is the major structural protein of CAV-1, accounting for approximately 25% of the total mass of the virus. This protein forms the capsid structure of the virus and helps protect its genetic material from the host's immune system. The hexon protein can also function as an antigen, triggering an immune response in the host animal and aiding in the detection of the virus.

CAV-1 primarily infects dogs, but it can also affect other canids such as foxes and wolves. Infection often occurs through exposure to bodily fluids like urine, saliva, and feces, as well as contaminated surfaces such as food bowls and toys. Once inside the host animal's body, the virus targets specific cells in the liver and respiratory system, causing a range of diseases.

Canine hepatitis is a severe liver infection caused by CAV-1. Symptoms of the disease include vomiting, diarrhea, lethargy, fever, abdominal pain, and loss of appetite. The virus attacks liver cells and damages their ability to function correctly, leading to liver failure and potentially death. Canine hepatitis can be particularly dangerous for puppies and senior dogs, as well as those with underlying health conditions.

In addition to liver infections, CAV-1 can also cause respiratory infections such as kennel cough. This disease is highly contagious and spreads rapidly in areas where many dogs congregate, such as kennels or dog parks. Symptoms of kennel cough include a dry, hacking cough, runny nose, and fever. In severe cases, the infection can progress to pneumonia, which can be life-threatening.

Effective diagnosis and treatment of CAV-1 infections are crucial for managing the disease. Diagnostic methods include PCR and ELISA tests that target specific genes or proteins in the virus, such as the E1A gene or the hexon protein. Serology tests can measure an animal's immune system's response to the virus, while virus isolation involves growing the virus in cell culture to detect its presence.

There is currently no specific treatment for CAV-1 infections, but supportive care can help alleviate symptoms and aid in recovery. Treatment may involve intravenous fluids, antibiotics to prevent secondary infections, and medication to manage pain and fever. Vaccinations are available to protect against CAV-1 infections, and vaccination is recommended for all dogs to reduce their risk of infection.

In conclusion, CAV-1 is a highly infectious virus that can cause severe liver and respiratory infections in dogs. The virus is genetically complex, with a unique replication cycle and distinct structural features. Effective diagnosis using techniques like PCR and ELISA can help identify the presence of the virus, allowing for prompt treatment and management of infected animals. Vaccination is an essential tool in preventing CAV-1 infections and protecting the health and wellbeing of dogs.

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