Feline parvovirus VP2 antibody and antigen (recombinant protein)

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Diagnostic anti-Feline parvovirus VP2 antibodies pairs and antigen for animal health (animal Cat/Feline infectious disease Feline panleukopenia) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P020-Tg001-Ag01	Recombinant Feline parvovirus VP2 protein	$3090.00
GMP-VT-P020-Tg001-Ab01	Anti-Feline parvovirus VP2 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P020-Tg001-Ab02	Anti-Feline parvovirus VP2 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P020-Tg001-Ab03	Anti-Feline parvovirus VP2 human monoclonal antibody (mAb)	$3090.00
GMP-VT-P020-Tg001-Ab04	Anti-Feline parvovirus VP2 human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P020-Tg001-Ag01
Product Name	Recombinant Feline parvovirus VP2 protein
Pathogen	Feline parvovirus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Feline parvovirus VP2 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Feline parvovirus level test of animal Cat/Feline infectious disease with Feline panleukopenia.
Tag	His
Product description	Recombinant Feline parvovirus VP2 proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P020-Tg001-Ab01,GMP-VT-P020-Tg001-Ab02
Pathogen	Feline parvovirus
Product Name	Anti-Feline parvovirus VP2 mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Feline parvovirus VP2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline parvovirus antibodies in Feline parvovirus level test of animal Cat/Feline infectious disease with Feline panleukopenia.
Product description	Anti-Feline parvovirus VP2 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline parvovirus antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P020-Tg001-Ab03,GMP-VT-P020-Tg001-Ab04
Pathogen	Feline parvovirus
Product Name	Anti-Feline parvovirus VP2 human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Feline parvovirus VP2 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline parvovirus antibodies in Feline parvovirus level test of animal Cat/Feline infectious disease with Feline panleukopenia.
Product description	Anti-Feline parvovirus VP2 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Feline parvovirus, also known as feline panleukopenia virus (FPV) or feline enteritis virus (FEV), is a highly contagious virus that can cause severe disease in cats. It belongs to the Parvoviridae family, which includes a range of small, non-enveloped, single-stranded DNA viruses that infect animals and humans.

The genome of feline parvovirus is relatively simple, consisting of a single-stranded DNA molecule that is approximately 5 kilobases in length. The viral genome encodes for two capsid proteins, VP1 and VP2, as well as non-structural proteins NS1 and NS2. VP2 is the main structural protein of the virion and plays a critical role in viral attachment to host cell receptors and immune recognition. In addition, VP2 is the primary target of neutralizing antibodies that are produced in response to infection or vaccination.

Domestic cats and some wild cat species such as lynx, bobcats, and cheetahs are susceptible to infection with feline parvovirus. The virus is highly contagious and can spread through direct contact with infected cats or contaminated fomites such as food bowls, litter boxes, or bedding. In addition, the virus can be shed in the feces and urine of infected cats for up to six weeks after infection, which can further contribute to environmental contamination and transmission.

The most common disease caused by feline parvovirus is feline panleukopenia, also known as feline distemper. This disease is characterized by severe vomiting, diarrhea, leukopenia, anemia, lymphoid depletion, and neurological symptoms. In unvaccinated cats, especially kittens, the mortality rate can be as high as 90%. The pathogenesis of feline panleukopenia is complex and involves several stages of viral replication and immune response. After initial viral replication in the oropharynx, the virus enters the bloodstream and infects rapidly dividing cells in the bone marrow, lymphoid tissues, and intestinal crypts. The high replication rate of the virus leads to severe leukopenia and lymphoid depletion, which can result in secondary bacterial or viral infections.

Diagnosis of feline parvovirus infection can be challenging due to the non-specific nature of clinical signs and the low levels of viral shedding that may occur early in the course of infection. However, several diagnostic methods are available, including enzyme-linked immunosorbent assay (ELISA), polymerase chain reaction (PCR), hemagglutination, and virus isolation. ELISA detects the presence of viral antigens in biological samples, while PCR amplifies and detects viral DNA. Both methods target the VP2 gene, which is highly conserved among feline parvovirus isolates. Hemagglutination and virus isolation are less commonly used due to their lower sensitivity and specificity.

Prevention of feline parvovirus infection relies primarily on vaccination. A highly effective vaccine against feline panleukopenia is available and is typically administered as part of a combination vaccine that also includes protection against feline herpesvirus and calicivirus. Vaccination is recommended for all cats, starting at 6-8 weeks of age and continuing on a regular basis throughout their lives.

In conclusion, feline parvovirus is a highly contagious virus that can cause severe disease in cats. The virus belongs to the Parvoviridae family and has a relatively simple genome that encodes for two capsid proteins, VP1 and VP2, as well as non-structural proteins NS1 and NS2. Diagnosis of feline parvovirus infection can be challenging, but several diagnostic methods are available, including ELISA, PCR, hemagglutination, and virus isolation. Vaccination is the primary method of prevention, and all cats should be vaccinated against feline panleukopenia starting at 6-8 weeks of age.

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