Francisella tularensis Outer Membrane Protein A (FopA) antibody and antigen (recombinant protein)

Diagnostic anti-Francisella tularensis Outer Membrane Protein A (FopA) antibodies pairs and antigen for animal health (animal Rabbit, Hare, Rodent infectious disease rabbit fever) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No. Description US $ Price (per mg)
GMP-VT-P035-Tg001-Ag01 Recombinant Francisella tularensis Outer Membrane Protein A (FopA) protein $3090.00
GMP-VT-P035-Tg001-Ab01 Anti-Francisella tularensis Outer Membrane Protein A (FopA) mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P035-Tg001-Ab02 Anti-Francisella tularensis Outer Membrane Protein A (FopA) mouse monoclonal antibody (mAb) $3090.00
GMP-VT-P035-Tg001-Ab03 Anti-Francisella tularensis Outer Membrane Protein A (FopA) human monoclonal antibody (mAb) $3090.00
GMP-VT-P035-Tg001-Ab04 Anti-Francisella tularensis Outer Membrane Protein A (FopA) human monoclonal antibody (mAb) $3090.00

Size: 1mg | 10mg | 100mg



Product Description

Cat No. GMP-VT-P035-Tg001-Ag01
Product Name Recombinant Francisella tularensis Outer Membrane Protein A (FopA) protein
Pathogen Francisella tularensis
Expression platform E.coli
Isotypes Recombinant Antigen
Bioactivity validation Anti-Francisella tularensis Outer Membrane Protein A (FopA) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Francisella tularensis level test of animal Rabbit, Hare, Rodent infectious disease with rabbit fever.
Tag His
Product description Recombinant Francisella tularensis Outer Membrane Protein A (FopA) proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P035-Tg001-Ab01,GMP-VT-P035-Tg001-Ab02
Pathogen Francisella tularensis
Product Name Anti-Francisella tularensis Outer Membrane Protein A (FopA) mouse monoclonal antibody (mAb)
Expression platform CHO
Isotypes Mouse IgG
Bioactivity validation Recombinant Francisella tularensis Outer Membrane Protein A (FopA) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Francisella tularensis antibodies in Francisella tularensis level test of animal Rabbit, Hare, Rodent infectious disease with rabbit fever.
Product description Anti-Francisella tularensis Outer Membrane Protein A (FopA) mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Francisella tularensis antibodies.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No. GMP-VT-P035-Tg001-Ab03,GMP-VT-P035-Tg001-Ab04
Pathogen Francisella tularensis
Product Name Anti-Francisella tularensis Outer Membrane Protein A (FopA) human monoclonal antibody (mAb)
Expression platform CHO
Isotypes Human lgG1
Bioactivity validation Recombinant Francisella tularensis Outer Membrane Protein A (FopA) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Francisella tularensis antibodies in Francisella tularensis level test of animal Rabbit, Hare, Rodent infectious disease with rabbit fever.
Product description Anti-Francisella tularensis Outer Membrane Protein A (FopA) mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity Purity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


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    Pathogen Information


    Francisella tularensis is a highly dangerous and infectious pathogen responsible for the zoonotic disease tularemia. This bacterium is an atypical gram-negative, non-motile, and aerobic bacterium that belongs to the family Francisellaceae. It is classified as a facultative intracellular pathogen, meaning that it can replicate in both host cells and within the extracellular environment.

    Tularemia, also known as rabbit fever or deer fly fever, is caused by Francisella tularensis in a wide range of mammals, including rodents, rabbits, and hares. It is also known to infect birds and humans, leading to severe health implications. Tularemia is a significant public health concern due to its high infectivity, potential for aerosol transmission, and lethal consequences if left untreated.

    The pathogen's genome is relatively small compared to other bacteria, consisting of about 1.9 Mb of genetic material. It carries a plasmid called pFtL, which encodes several essential virulence factors required for the full expression of pathogenicity. The pathogen lacks traditional bacterial structures like flagella and pilli, making it less motile and unable to move as quickly as other pathogenic bacteria. Instead, it utilizes a unique needle-like structure to inject host cells with virulence factors that aid its replication and survival within the host cell.

    The pathogenicity of Francisella tularensis depends on several key genes and proteins. One of the most critical genes is the tul4 gene, which encodes a lipoprotein essential for the bacteria's survival within host immune cells. This protein aids in evading host immune responses and helps the bacteria replicate within host cells. Another crucial gene is the iglC gene, which plays an essential role in intracellular growth and replication, allowing the pathogen to continue its spread throughout the host.

    Francisella tularensis can cause severe health implications in humans, with symptoms ranging from mild flu-like symptoms, such as fever and headache, to severe complications like pneumonia, sepsis, and organ failure. Tularemia is primarily a disease of rural areas where rodents and other small animals that carry the pathogen are abundant. It can also occur after ingestion of contaminated food or water, handling infected animals, or through tick and insect bites.

    Diagnostic methods for tularemia rely on detecting specific antibodies against the pathogen through serological tests like the microagglutination assay (MAA) or Enzyme-Linked Immunosorbent Assay (ELISA). In recent years, nucleic acid amplification tests (NAATs) have also become commonly used for diagnosis, targeting genes such as the 16S rRNA gene, FopA gene, or the tul4 gene. These methods can detect the presence of the pathogen in clinical samples such as blood, sputum, or cerebrospinal fluid. The use of PCR-based assays has revolutionized the field of microbiology, and the development of novel molecular methods for rapid detection of Francisella tularensis has been a significant breakthrough in the diagnosis and management of tularemia.

    In conclusion, Francisella tularensis is a dangerous and highly infectious pathogen responsible for Tularemia. Its unique characteristics and virulence mechanisms make it a challenging pathogen to study and diagnose. A better understanding of the pathogen's genetics and biology will go a long way in helping develop more effective diagnostic and therapeutic strategies.



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