Mycobacterium antibody and antigen (recombinant protein)

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Diagnostic anti-Mycobacterium antibodies pairs and antigen for animal health (animal Bovines/Cattle infectious disease tuberculosis/leprosy) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P049-Tg001-Ag01	Recombinant Mycobacterium protein	$3090.00
GMP-VT-P049-Tg001-Ab01	Anti-Mycobacterium mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P049-Tg001-Ab02	Anti-Mycobacterium mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P049-Tg001-Ab03	Anti-Mycobacterium human monoclonal antibody (mAb)	$3090.00
GMP-VT-P049-Tg001-Ab04	Anti-Mycobacterium human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P049-Tg001-Ag01
Product Name	Recombinant Mycobacterium protein
Pathogen	Mycobacterium
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Mycobacterium antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Mycobacterium level test of animal Bovines/Cattle infectious disease with tuberculosis/leprosy.
Tag	His
Product description	Recombinant Mycobacterium proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P049-Tg001-Ab01,GMP-VT-P049-Tg001-Ab02
Pathogen	Mycobacterium
Product Name	Anti-Mycobacterium mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Mycobacterium antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Mycobacterium antibodies in Mycobacterium level test of animal Bovines/Cattle infectious disease with tuberculosis/leprosy.
Product description	Anti-Mycobacterium mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Mycobacterium antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P049-Tg001-Ab03,GMP-VT-P049-Tg001-Ab04
Pathogen	Mycobacterium
Product Name	Anti-Mycobacterium human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Mycobacterium antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Mycobacterium antibodies in Mycobacterium level test of animal Bovines/Cattle infectious disease with tuberculosis/leprosy.
Product description	Anti-Mycobacterium mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Pathogen Information

Mycobacterium is a diverse group of acid-fast bacteria that includes both pathogenic and non-pathogenic species. They are gram-positive, rod-shaped, and have a waxy cell wall, which is composed of mycolic acids that make them resistant to disinfectants, antibiotics, and the immune system.

The genus Mycobacterium includes over 190 species, with a variety of lifestyles and habitats. Most species inhabit soil and water, while some are associated with animals or humans as pathogens, including M. tuberculosis, M. leprae, M. ulcerans, and M. avium. M. tuberculosis can cause tuberculosis (TB), which is a major global health problem, infecting over 10 million people annually, resulting in over 1.5 million deaths each year. TB primarily affects the lungs but can also affect other organs such as the kidneys, spine, and brain. The disease is transmitted through the air when infected individuals cough or sneeze, and it is a particular problem in resource-limited settings with poor access to healthcare.

M. leprae, another pathogenic Mycobacterium, causes leprosy, a chronic infectious disease that mainly affects the skin and nerves. While it is a rare disease globally, it remains endemic in some regions, particularly in India, Brazil, and Africa. M. ulcerans can cause Buruli ulcer, a neglected tropical disease that results in destructive skin ulcers and tissue damage. The infection is caused by exposure to contaminated water or soil, and while it is rare, it can cause significant morbidity if not treated promptly.

The cell wall structure of Mycobacterium is unique and plays a key role in many aspects of its biology, including virulence, drug resistance, and immunogenicity. The cell wall contains several complex lipids, including mycolic acids, which are responsible for the acid-fast staining properties of these bacteria and their resistance to many chemical and physical agents. Additionally, the cell wall contains a variety of other glycolipids, phospholipids, and lipoglycans that are critical for the bacteria's survival and pathogenesis.

The rpoB gene encodes the beta subunit of RNA polymerase and is highly conserved in Mycobacterium species. It is commonly used as a target for molecular identification and drug susceptibility testing of Mycobacterium isolates. NAATs, such as PCR and TMA, can detect the presence of Mycobacterium DNA or RNA in clinical samples and target specific genes to differentiate Mycobacterium species. Culture and isolation of Mycobacterium can be challenging due to their slow growth rate, but it remains a gold standard method for diagnosis and drug susceptibility testing.

Serological tests can detect specific antibodies produced by the host in response to Mycobacterium infection. However, these tests have limitations in sensitivity and specificity and are not commonly used for primary diagnosis.

In conclusion, Mycobacterium is a diverse and fascinating group of bacteria with many important species that cause significant human and animal diseases. The unique cell wall structure of Mycobacterium is a key feature that contributes to its virulence, antibiotic resistance, and immunogenicity, and is an important target for diagnostic and therapeutic interventions. Advances in molecular biology and genomics are providing new insights into the biology and evolution of Mycobacterium, which will help in the development of better tools for diagnosis, treatment, and prevention of Mycobacterium infections.

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