Blue tongue Virus VP3 antibody and antigen (recombinant protein)

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Diagnostic anti-Blue tongue Virus VP3 antibodies pairs and antigen for animal health (animal Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Deer infectious disease Bluetongue disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P062-Tg002-Ag01	Recombinant Blue tongue Virus VP3 protein	$3090.00
GMP-VT-P062-Tg002-Ab01	Anti-Blue tongue Virus VP3 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P062-Tg002-Ab02	Anti-Blue tongue Virus VP3 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P062-Tg002-Ab03	Anti-Blue tongue Virus VP3 human monoclonal antibody (mAb)	$3090.00
GMP-VT-P062-Tg002-Ab04	Anti-Blue tongue Virus VP3 human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P062-Tg002-Ag01
Product Name	Recombinant Blue tongue Virus VP3 protein
Pathogen	Blue tongue Virus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Blue tongue Virus VP3 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Blue tongue Virus level test of animal Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Deer infectious disease with Bluetongue disease.
Tag	His
Product description	Recombinant Blue tongue Virus VP3 proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P062-Tg002-Ab01,GMP-VT-P062-Tg002-Ab02
Pathogen	Blue tongue Virus
Product Name	Anti-Blue tongue Virus VP3 mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Blue tongue Virus VP3 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Blue tongue Virus antibodies in Blue tongue Virus level test of animal Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Deer infectious disease with Bluetongue disease.
Product description	Anti-Blue tongue Virus VP3 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Blue tongue Virus antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P062-Tg002-Ab03,GMP-VT-P062-Tg002-Ab04
Pathogen	Blue tongue Virus
Product Name	Anti-Blue tongue Virus VP3 human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Blue tongue Virus VP3 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Blue tongue Virus antibodies in Blue tongue Virus level test of animal Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Deer infectious disease with Bluetongue disease.
Product description	Anti-Blue tongue Virus VP3 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Blue tongue virus (BTV) is an arbovirus that is primarily transmitted by Culicoides biting midges. BTV is the causative agent of bluetongue disease, which affects domestic and wild ruminants, including sheep, goats, cattle, and deer. The disease was first identified in South Africa in the early 20th century. Since then, outbreaks have been reported worldwide, with significant economic and animal welfare implications.

BTV is a non-enveloped virus with a genome composed of ten segments of double-stranded RNA. The viral genome encodes both structural and non-structural proteins. The outer capsid of BTV is composed of two major structural proteins, VP2 and VP5, and three minor proteins, VP1, VP3, and VP7. VP2 is responsible for the virus's antigenic properties and plays a crucial role in determining serotype specificity. VP7 forms the inner capsid shell surrounding the genomic RNA, while VP1 and VP3 are involved in cell attachment and entry.

Infection with BTV can lead to bluetongue disease, which manifests as a range of clinical signs. These include fever, lameness, and mouth ulcers. The severity of the disease depends on the viral strain, host species, and immune status of the animal. Subclinical infection is common, but in some cases, the disease can progress to a severe hemorrhagic syndrome, which can be fatal. The pathogenesis of BTV involves the replication of the virus in regional lymph nodes, followed by viremia and subsequent dissemination to other organs.

Diagnostic methods for BTV include serology, virus isolation, and molecular techniques, such as PCR or RT-PCR. Serological tests detect antibodies against BTV in serum samples and are used to determine whether an animal has been exposed to the virus. Virus isolation involves culturing BTV in susceptible cell lines, which allows for the identification of the viral strain. Molecular techniques, such as PCR or RT-PCR, are used to detect viral RNA in blood or tissue samples and are highly sensitive and specific. The target genes for these assays include the VP2, VP7, and NS1 genes of BTV.

Control of BTV is based on vaccination, vector control, and movement restrictions. Vaccination is the most effective tool for controlling bluetongue disease and involves the use of inactivated or attenuated vaccines. Vector control measures include the use of insecticides, physical barriers, and environmental modifications. Movement restrictions are also an important component of disease control, as they prevent the spread of infected animals or vectors between regions.

In conclusion, BTV is an arbovirus that causes bluetongue disease in domestic and wild ruminants. The virus is transmitted by biting midges and has a complex molecular structure. Infection with BTV can lead to a range of clinical signs, and accurate diagnostic methods are essential for disease control. Control measures for BTV involve vaccination, vector control, and movement restrictions.

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