Mycoplasma mycoides subsp. mycoides lipoprotein LppQ antibody and antigen (recombinant protein)

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Diagnostic anti-Mycoplasma mycoides subsp. mycoides lipoprotein LppQ antibodies pairs and antigen for animal health (animal Bovines/Cattle infectious disease contagious bovine pleuropneumonia) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P070-Tg001-Ag01	Recombinant Mycoplasma mycoides subsp. mycoides lipoprotein LppQ protein	$3090.00
GMP-VT-P070-Tg001-Ab01	Anti-Mycoplasma mycoides subsp. mycoides lipoprotein LppQ mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P070-Tg001-Ab02	Anti-Mycoplasma mycoides subsp. mycoides lipoprotein LppQ mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P070-Tg001-Ab03	Anti-Mycoplasma mycoides subsp. mycoides lipoprotein LppQ human monoclonal antibody (mAb)	$3090.00
GMP-VT-P070-Tg001-Ab04	Anti-Mycoplasma mycoides subsp. mycoides lipoprotein LppQ human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P070-Tg001-Ag01
Product Name	Recombinant Mycoplasma mycoides subsp. mycoides lipoprotein LppQ protein
Pathogen	Mycoplasma mycoides subsp. mycoides
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Mycoplasma mycoides subsp. mycoides lipoprotein LppQ antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Mycoplasma mycoides subsp. mycoides level test of animal Bovines/Cattle infectious disease with contagious bovine pleuropneumonia.
Tag	His
Product description	Recombinant Mycoplasma mycoides subsp. mycoides lipoprotein LppQ proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P070-Tg001-Ab01,GMP-VT-P070-Tg001-Ab02
Pathogen	Mycoplasma mycoides subsp. mycoides
Product Name	Anti-Mycoplasma mycoides subsp. mycoides lipoprotein LppQ mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Mycoplasma mycoides subsp. mycoides lipoprotein LppQ antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Mycoplasma mycoides subsp. mycoides antibodies in Mycoplasma mycoides subsp. mycoides level test of animal Bovines/Cattle infectious disease with contagious bovine pleuropneumonia.
Product description	Anti-Mycoplasma mycoides subsp. mycoides lipoprotein LppQ mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Mycoplasma mycoides subsp. mycoides antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P070-Tg001-Ab03,GMP-VT-P070-Tg001-Ab04
Pathogen	Mycoplasma mycoides subsp. mycoides
Product Name	Anti-Mycoplasma mycoides subsp. mycoides lipoprotein LppQ human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Mycoplasma mycoides subsp. mycoides lipoprotein LppQ antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Mycoplasma mycoides subsp. mycoides antibodies in Mycoplasma mycoides subsp. mycoides level test of animal Bovines/Cattle infectious disease with contagious bovine pleuropneumonia.
Product description	Anti-Mycoplasma mycoides subsp. mycoides lipoprotein LppQ mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Mycoplasma mycoides subsp. mycoides is a pathogenic bacterium that primarily infects cattle, causing a disease known as contagious bovine pleuropneumonia (CBPP). CBPP is a highly infectious respiratory disease that can lead to significant lung damage and mortality if left untreated.

The pathogen belongs to the family Mycoplasmataceae, which comprises small, self-replicating prokaryotic organisms that lack a cell wall. These bacteria have a minimal genome and rely on their host for many essential nutrients, making them obligate parasites. They can also adapt rapidly to changing environments and are known for their resistance to antibiotics.

Mycoplasma mycoides subsp. mycoides is a fastidious organism that requires special media and conditions for growth. It is capable of surviving in a range of environmental conditions, including high temperatures, low nutrient environments, and prolonged periods of desiccation, allowing it to persist in the environment for extended periods.

The pathogen's virulence is largely dependent on its ability to adhere to host cells and tissues. Adherence to host cells is facilitated by several proteins, including the P40 protein, which plays a vital role in the pathogen's adhesion mechanisms. P40 is a surface-exposed lipoprotein that is highly conserved among mycoplasma species. The protein consists of a C-terminal end that is anchored to the membrane and an N-terminal end that is exposed to the extracellular space. The N-terminal end contains a P40-specific region that mediates adhesion to host cells by interacting with specific receptors.

The pathogenesis of CBPP is complex, and the exact mechanisms by which Mycoplasma mycoides subsp. mycoides causes disease are not entirely understood. It is believed that CBPP infection initiates with inhalation of the pathogen into the lower respiratory tract, where it colonizes the lung tissue and triggers a host immune response. The pathogen's adhesion-related proteins allow it to attach to host cells, evade the host's immune system, and establish a persistent infection.

CBPP diagnosis can be challenging due to several factors, including the slow bacterial growth rate, low bacterial load in clinical specimens, and nonspecific clinical signs. Common diagnostic methods include serological testing, bacterial isolation, and nucleic acid-based detection methods like PCR and ELISA. These methods target specific genes and proteins, such as the P40 protein and the 16S ribosomal RNA gene, that are unique to Mycoplasma mycoides subsp. mycoides and its closely related species.

The treatment of CBPP is complex and often involves a combination of antibiotics and supportive care. Antibiotic treatment aims to reduce the pathogen load in the host while the immune system clears the infection. However, because of the minimal cell wall structure of the bacterium, mycoplasmas are resistant to many conventional antibiotics like penicillins, cephalosporins, and aminoglycosides. Tetracyclines, macrolides, and fluoroquinolones are often used instead for CBPP treatment.

In conclusion, Mycoplasma mycoides subsp. mycoides is a pathogenic bacterium that causes contagious bovine pleuropneumonia (CBPP) primarily in cattle. Its impact on host animals can be severe and even fatal if left untreated. Although there is still much to learn about its pathogenesis, advancements in diagnostic and therapeutic options have helped control its spread and minimize its impact on animal health.

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