PseudoRabies Virus gp50 antibody and antigen (recombinant protein)

 Download 

Diagnostic anti-PseudoRabies Virus gp50 antibodies pairs and antigen for animal health (animal Swine/Porcine/Pig infectious disease Pseudorabies) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Go to Swine/Porcine/Pig disease testing products collection >>

Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P105-Tg003-Ag01	Recombinant PseudoRabies Virus gp50 protein	$3090.00
GMP-VT-P105-Tg003-Ab01	Anti-PseudoRabies Virus gp50 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P105-Tg003-Ab02	Anti-PseudoRabies Virus gp50 mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P105-Tg003-Ab03	Anti-PseudoRabies Virus gp50 human monoclonal antibody (mAb)	$3090.00
GMP-VT-P105-Tg003-Ab04	Anti-PseudoRabies Virus gp50 human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P105-Tg003-Ag01
Product Name	Recombinant PseudoRabies Virus gp50 protein
Pathogen	PseudoRabies Virus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-PseudoRabies Virus gp50 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in PseudoRabies Virus level test of animal Swine/Porcine/Pig infectious disease with Pseudorabies.
Tag	His
Product description	Recombinant PseudoRabies Virus gp50 proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P105-Tg003-Ab01,GMP-VT-P105-Tg003-Ab02
Pathogen	PseudoRabies Virus
Product Name	Anti-PseudoRabies Virus gp50 mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant PseudoRabies Virus gp50 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PseudoRabies Virus antibodies in PseudoRabies Virus level test of animal Swine/Porcine/Pig infectious disease with Pseudorabies.
Product description	Anti-PseudoRabies Virus gp50 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PseudoRabies Virus antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P105-Tg003-Ab03,GMP-VT-P105-Tg003-Ab04
Pathogen	PseudoRabies Virus
Product Name	Anti-PseudoRabies Virus gp50 human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant PseudoRabies Virus gp50 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-PseudoRabies Virus antibodies in PseudoRabies Virus level test of animal Swine/Porcine/Pig infectious disease with Pseudorabies.
Product description	Anti-PseudoRabies Virus gp50 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Pathogen Information

Pseudorabies virus (PRV), also known as Aujeszky's disease virus or Porcine herpesvirus 1 (PHV-1), is a highly infectious agent that belongs to the Herpesviridae family. This virus is characterized by its double-stranded DNA genome and its neurotropic nature, meaning it specifically targets the nervous system of infected hosts. PRV is primarily a disease of pigs, but it can infect many other mammalian species, including cattle, sheep, goats, dogs, cats, and wild carnivores. Infected animals can present with various clinical symptoms.

The structure of PRV is complex, consisting of several structural proteins including glycoproteins gB, gC, gD, gH, and gL. These envelope proteins facilitate the attachment and entry of the virus into host cells. PRV is unique among herpesviruses in that it can spread via multiple routes, including direct contact between animals, aerosol transmission, ingestion of contaminated feed, and even via contaminated fomites such as clothing and equipment.

The UL44 gene of PRV encodes for the DNA polymerase processivity factor, which is essential for replication and propagation of the virus. The gE gene of PRV encodes for a virion envelope protein. The gE protein plays a key role in neuroinvasion and the establishment of latency in the nervous system. The gE protein can also inhibit the migration of dendritic cells to lymph nodes, which may contribute to immune evasion by the virus.

Pigs are the natural host of PRV, and the virus is endemic in many pig populations worldwide. In pigs, PRV infection results in Aujeszky's disease, which is characterized by fever, respiratory distress, and neurological symptoms such as convulsions, ataxia, and hyperthermia. In severe cases, mortality rates can be as high as 100%, particularly in young pigs. Although Aujeszky's disease is a significant concern for the swine industry, the virus can also be transmitted to other animals, including dogs and wild carnivores. In these animals, the virus may cause respiratory issues, fever, and even death.

Diagnosing PRV infection can be challenging because clinical signs may vary between species. However, there are a range of diagnostic methods available. Serological tests such as enzyme-linked immunosorbent assay (ELISA) and virus neutralization test can detect antibodies against PRV in blood samples. Nucleic acid-based techniques, including polymerase chain reaction (PCR) and reverse transcription-PCR (RT-PCR), can detect viral DNA in clinical samples such as nasal swabs, blood, and tissues. These PCR assays typically target specific genes, such as the gE gene, which is highly conserved among PRV strains. Immunohistochemistry can also be used to identify the presence of virus antigen in tissue samples.

Preventing and controlling PRV infection is critical for protecting animal health and the swine industry. Vaccination is an effective way to control PRV in pigs. Inactivated or live attenuated PRV vaccines are available and have been widely used in many countries. Proper biosecurity measures, including cleaning and disinfection of equipment and facilities, can also help reduce the risk of PRV transmission. Additionally, early detection and reporting of suspected cases to veterinary authorities can facilitate rapid control and prevention measures.

In conclusion, Pseudorabies virus is a complex and highly infectious agent that primarily affects pigs but can also impact many other mammalian species. Understanding the structure, replication, and transmission of this virus is essential for developing effective control strategies to minimize its impact on animal health and the swine industry.

About GDU