Infectious Bronchitis Virus - Variant IB80 S gene antibody and antigen (recombinant protein)

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Diagnostic anti-Infectious Bronchitis Virus - Variant IB80 S gene antibodies pairs and antigen for animal health (animal Avian/Bird/Poultry infectious disease respiratory disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P153-Tg001-Ag01	Recombinant Infectious Bronchitis Virus - Variant IB80 S gene protein	$3090.00
GMP-VT-P153-Tg001-Ab01	Anti-Infectious Bronchitis Virus - Variant IB80 S gene mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P153-Tg001-Ab02	Anti-Infectious Bronchitis Virus - Variant IB80 S gene mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P153-Tg001-Ab03	Anti-Infectious Bronchitis Virus - Variant IB80 S gene human monoclonal antibody (mAb)	$3090.00
GMP-VT-P153-Tg001-Ab04	Anti-Infectious Bronchitis Virus - Variant IB80 S gene human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P153-Tg001-Ag01
Product Name	Recombinant Infectious Bronchitis Virus - Variant IB80 S gene protein
Pathogen	Infectious Bronchitis Virus - Variant IB80
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Infectious Bronchitis Virus - Variant IB80 S gene antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Infectious Bronchitis Virus - Variant IB80 level test of animal Avian/Bird/Poultry infectious disease with respiratory disease.
Tag	His
Product description	Recombinant Infectious Bronchitis Virus - Variant IB80 S gene proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P153-Tg001-Ab01,GMP-VT-P153-Tg001-Ab02
Pathogen	Infectious Bronchitis Virus - Variant IB80
Product Name	Anti-Infectious Bronchitis Virus - Variant IB80 S gene mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Infectious Bronchitis Virus - Variant IB80 S gene antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Infectious Bronchitis Virus - Variant IB80 antibodies in Infectious Bronchitis Virus - Variant IB80 level test of animal Avian/Bird/Poultry infectious disease with respiratory disease.
Product description	Anti-Infectious Bronchitis Virus - Variant IB80 S gene mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Infectious Bronchitis Virus - Variant IB80 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P153-Tg001-Ab03,GMP-VT-P153-Tg001-Ab04
Pathogen	Infectious Bronchitis Virus - Variant IB80
Product Name	Anti-Infectious Bronchitis Virus - Variant IB80 S gene human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Infectious Bronchitis Virus - Variant IB80 S gene antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Infectious Bronchitis Virus - Variant IB80 antibodies in Infectious Bronchitis Virus - Variant IB80 level test of animal Avian/Bird/Poultry infectious disease with respiratory disease.
Product description	Anti-Infectious Bronchitis Virus - Variant IB80 S gene mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Infectious Bronchitis Virus (IBV) is a highly contagious viral disease that affects chickens worldwide. The disease is primarily transmitted via aerosols or direct contact with infected birds, and it causes significant economic losses within the poultry industry. The Infectious Bronchitis Virus - Variant IB80 is a strain of the IBV that has been identified in multiple countries and is known for causing severe respiratory and renal pathology in poultry.

The Infectious Bronchitis Virus - Variant IB80 is classified as a virus belonging to the Coronaviridae family, which encompasses a wide range of human and animal pathogens, including the human coronaviruses responsible for SARS and COVID-19. The IBV is an enveloped RNA virus, and its genome is comprised of a single-stranded positive-sense RNA molecule that encodes for several structural and non-structural proteins essential for viral replication, assembly, and release.

The IBV genome encodes for four primary structural proteins necessary for the virus's life-cycle, including the spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins. The S protein, also known as the peplomer protein, is a critical component of the virus's envelope that mediates viral attachment to host cells. The S protein contains two subunits: S1, which binds to the host cell receptor, and S2, which facilitates viral entry by receptor-mediated endocytosis. The E protein is involved in viral assembly and release, while the M protein plays a role in regulating the virus's size and shape. Finally, the N protein encapsulates the RNA genome and plays a crucial role in viral assembly and replication.

The pathogenesis of the Infectious Bronchitis Virus - Variant IB80 in chickens is complex and involves multiple factors, including host genetics, viral virulence, and environmental factors. Upon infection, the virus primarily targets the epithelial cells lining the respiratory and renal tracts. The virus's entry into the host cell is mediated by the S protein binding to its specific receptor on the host cell surface. After attachment, the virus is internalized into the cell via endocytosis.

Once inside the cell, the virus begins replicating its RNA genome using the host cellular machinery. The viral RNA is then translated into viral proteins that are secreted, processed, and assembled into new viral particles. The newly formed viruses exit the host cell via budding and then spread to other cells throughout the respiratory and renal tracts, leading to further tissue damage and inflammation.

The clinical signs associated with Infectious Bronchitis Virus - Variant IB80 infection in chickens vary depending on the age of the bird, the viral dose, and the strain of the virus. Some of the most common clinical signs include respiratory distress, swollen sinuses, watery eyes, nasal discharge, decreased egg production, and eggshell abnormalities. Infected birds may also exhibit neurological signs such as tremors and paralysis.

Several diagnostic methods exist for detecting Infectious Bronchitis Virus - Variant IB80 infections in poultry. The most commonly used diagnostic method is Reverse Transcriptase Polymerase Chain Reaction (RT-PCR), which detects viral RNA in samples collected from infected birds. Other diagnostic methods include virus isolation, serological testing to detect antibodies against the virus, and Enzyme-Linked Immunosorbent Assay (ELISA) to detect viral antigens in blood or other fluids. These diagnostic methods target specific genes or proteins, such as the N gene and S protein of the virus.

In conclusion, the Infectious Bronchitis Virus - Variant IB80 is a highly contagious avian coronavirus that causes significant economic losses within the poultry industry. The virus primarily targets the respiratory and renal tracts of infected birds, leading to severe pathology and decreased egg production. Several diagnostic methods exist for detecting IBV infections, including RT-PCR, virus isolation, serological testing, and ELISA. Understanding the biology and pathogenesis of the virus is essential for developing effective control measures and vaccines that can prevent and limit the spread of this important poultry disease.

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