Salmonella Gallinarum antibody and antigen (recombinant protein)

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Diagnostic anti-Salmonella Gallinarum antibodies pairs and antigen for animal health (animal Chicken, Duck, Turkey, Pheasants, Quail, Grouse, Peafowl, Guinea-fowl infectious disease Fowl typhoid) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P155-Tg001-Ag01	Recombinant Salmonella Gallinarum protein	$3090.00
GMP-VT-P155-Tg001-Ab01	Anti-Salmonella Gallinarum mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P155-Tg001-Ab02	Anti-Salmonella Gallinarum mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P155-Tg001-Ab03	Anti-Salmonella Gallinarum human monoclonal antibody (mAb)	$3090.00
GMP-VT-P155-Tg001-Ab04	Anti-Salmonella Gallinarum human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P155-Tg001-Ag01
Product Name	Recombinant Salmonella Gallinarum protein
Pathogen	Salmonella Gallinarum
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Salmonella Gallinarum antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Salmonella Gallinarum level test of animal Chicken, Duck, Turkey, Pheasants, Quail, Grouse, Peafowl, Guinea-fowl infectious disease with Fowl typhoid.
Tag	His
Product description	Recombinant Salmonella Gallinarum proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P155-Tg001-Ab01,GMP-VT-P155-Tg001-Ab02
Pathogen	Salmonella Gallinarum
Product Name	Anti-Salmonella Gallinarum mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Salmonella Gallinarum antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Salmonella Gallinarum antibodies in Salmonella Gallinarum level test of animal Chicken, Duck, Turkey, Pheasants, Quail, Grouse, Peafowl, Guinea-fowl infectious disease with Fowl typhoid.
Product description	Anti-Salmonella Gallinarum mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Salmonella Gallinarum antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P155-Tg001-Ab03,GMP-VT-P155-Tg001-Ab04
Pathogen	Salmonella Gallinarum
Product Name	Anti-Salmonella Gallinarum human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Salmonella Gallinarum antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Salmonella Gallinarum antibodies in Salmonella Gallinarum level test of animal Chicken, Duck, Turkey, Pheasants, Quail, Grouse, Peafowl, Guinea-fowl infectious disease with Fowl typhoid.
Product description	Anti-Salmonella Gallinarum mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Salmonella Gallinarum is a Gram-negative bacterium that belongs to the family Enterobacteriaceae, which includes other notable pathogens like Escherichia coli and Klebsiella pneumoniae. This bacterium is an important cause of systemic infections in poultry, including chickens, turkeys, geese, ducks, quails, and pheasants. The pathogen can also infect other warm-blooded animals, including humans, leading to a severe disease called paratyphoid fever.

S. Gallinarum was first discovered in 1898 by a British veterinarian, Frederick George Hare, who observed it in the blood and organs of chickens with fowl typhoid. Fowl typhoid is a severe and often fatal disease of chickens that causes poor growth, decreased egg production, diarrhea, depression, anorexia, and mortality rates of up to 90%. The disease is characterized by a systemic infection that affects many organs and tissues, such as the liver, spleen, kidneys, lungs, and intestines. Infected chickens shed the bacteria in their feces, which can contaminate the environment and other animals.

Salmonella Gallinarum is a facultative intracellular pathogen, capable of invading and replicating within host cells, including macrophages and epithelial cells. The pathogen's ability to survive and multiply inside host cells is critical for its virulence and the development of systemic infections. The pathogen achieves this by producing numerous virulence factors, including adhesins, invasins, toxins, iron acquisition systems, and effector proteins, which are encoded on the genomic island called Salmonella Pathogenicity Island (SPI). SPI-1 and SPI-2 are the two most studied islands that encode type III secretion systems (T3SS), which are used to inject virulence factors directly into target cells.

One of the most important virulence factors of Salmonella Gallinarum is flagellin, the protein that makes up the bacterial flagellum, a whip-like appendage used for motility and host cell recognition. Flagellin is recognized by pattern recognition receptors (PRRs), such as Toll-like receptor 5 (TLR5), which triggers an immune response by inducing the production of pro-inflammatory cytokines like interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interleukin-8 (IL-8). The response helps recruit immune cells to the site of infection and activate antibacterial mechanisms.

Salmonella Gallinarum infections can be diagnosed using a combination of methods, including bacterial culture from blood and tissues, serological testing, and nucleic acid-based assays, such as Polymerase Chain Reaction (PCR) and loop-mediated isothermal amplification (LAMP). Bacterial culture allows isolation and identification of the pathogen from infected samples, while serological testing detects antibodies produced by the host against the pathogen. Nucleic acid-based assays are more rapid and sensitive than traditional culture and serology methods, as they can detect low levels of the pathogen's DNA or RNA directly from clinical samples. PCR and LAMP are commonly used for the detection of specific virulence genes associated with Salmonella Gallinarum, such as the SPI-2 genes or the invA gene. Additionally, the Vitek 2 system is a commercial diagnostic tool that uses automated technology to identify Salmonella species, including Salmonella Gallinarum. The system detects bacterial growth and metabolic activities using colorimetric reactions and can provide results in about 18 hours.

In conclusion, Salmonella Gallinarum is a significant pathogen that causes severe systemic infections in poultry and occasional human infections. The pathogen has a complex pathogenesis that involves multiple virulence factors, including flagellin and SPI-encoded genes. Diagnostic methods for the pathogen include traditional culture and serology methods, as well as nucleic acid-based assays, such as PCR and LAMP. Rapid identification systems like the Vitek 2 system are also available commercially. Understanding the pathogenesis and diagnostic methods of the pathogen is crucial to managing fowl typhoid and preventing its spread to other animals and humans.

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