Avian pneumovirus NP antibody and antigen (recombinant protein)

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Diagnostic anti-Avian pneumovirus NP antibodies pairs and antigen for animal health (animal Chicken, Turkey infectious disease upper respiratory tract infection) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P164-Tg001-Ag01	Recombinant Avian pneumovirus NP protein	$3090.00
GMP-VT-P164-Tg001-Ab01	Anti-Avian pneumovirus NP mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P164-Tg001-Ab02	Anti-Avian pneumovirus NP mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P164-Tg001-Ab03	Anti-Avian pneumovirus NP human monoclonal antibody (mAb)	$3090.00
GMP-VT-P164-Tg001-Ab04	Anti-Avian pneumovirus NP human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P164-Tg001-Ag01
Product Name	Recombinant Avian pneumovirus NP protein
Pathogen	Avian pneumovirus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Avian pneumovirus NP antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Avian pneumovirus level test of animal Chicken, Turkey infectious disease with upper respiratory tract infection.
Tag	His
Product description	Recombinant Avian pneumovirus NP proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P164-Tg001-Ab01,GMP-VT-P164-Tg001-Ab02
Pathogen	Avian pneumovirus
Product Name	Anti-Avian pneumovirus NP mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Avian pneumovirus NP antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian pneumovirus antibodies in Avian pneumovirus level test of animal Chicken, Turkey infectious disease with upper respiratory tract infection.
Product description	Anti-Avian pneumovirus NP mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian pneumovirus antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P164-Tg001-Ab03,GMP-VT-P164-Tg001-Ab04
Pathogen	Avian pneumovirus
Product Name	Anti-Avian pneumovirus NP human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Avian pneumovirus NP antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Avian pneumovirus antibodies in Avian pneumovirus level test of animal Chicken, Turkey infectious disease with upper respiratory tract infection.
Product description	Anti-Avian pneumovirus NP mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Avian pneumovirus is a respiratory pathogen that causes significant economic losses in the poultry industry worldwide. This disease is also known as Turkey Rhinotracheitis Virus (TRTV), Swollen Head Syndrome Virus (SHSV), and Metapneumovirus. The virus was first identified in turkeys in South Africa in the 1970s and has since spread to many countries, including the United States, Canada, Germany, France, Italy, and Israel.

Avian pneumovirus is a member of the family Pneumoviridae, which is a group of enveloped viruses with a negative-sense single-stranded RNA genome. The family comprises two genera, Orthopneumovirus and Metapneumovirus. The former includes human respiratory syncytial virus (RSV) and bovine respiratory syncytial virus (BRSV), while the latter includes avian pneumovirus and human metapneumovirus (HMPV).

The Avian pneumovirus genome is approximately 14 kb in size and encodes nine genes, including the nucleocapsid protein, the phosphoprotein, the matrix protein, the fusion (F) protein, the attachment (G) protein, the small hydrophobic (SH) protein, the large polymerase (L) protein, the non-structural (NS) protein, and the M2-1 protein. Among these, the G and F glycoproteins play critical roles in viral entry and host cell recognition. The G protein is responsible for virus binding to host cell receptors, while the F protein mediates the fusion of the viral envelope with host cell membranes, allowing the virus to enter the host cell.

Avian pneumovirus can infect numerous bird species, including commercial turkey and chicken flocks, guinea fowl, pheasants, and wild birds. The virus is transmitted through direct contact with infected birds or indirectly via contaminated fomites, such as equipment, feed, water, and personnel. Infected birds may show mild to severe respiratory symptoms, including nasal discharge, coughing, sneezing, conjunctivitis, tracheal rales, and wheezing. In severe cases, the disease can lead to swollen head syndrome, which is characterized by facial swelling due to sinus inflammation and blockage.

Diagnosis of Avian pneumovirus infection relies on a combination of clinical signs, histopathology, serology, and molecular methods. Clinical signs may suggest the presence of the virus, but they are non-specific and may overlap with those caused by other respiratory pathogens. Histopathology can reveal characteristic lesions in the respiratory tract, such as epithelial cell necrosis, syncytial cell formation, and inflammatory infiltrates. Serological assays detect antibodies against the virus, but they may cross-react with other pneumoviruses, leading to false-positive results. Molecular methods, such as reverse transcription polymerase chain reaction (RT-PCR) and real-time RT-PCR, are highly sensitive and specific for detecting Avian pneumovirus RNA in clinical samples, such as nasal swabs, tracheal aspirates, and tissues. These tests target various parts of the viral genome, including the G gene, the F gene, the L gene, and the N gene.

Control of Avian pneumovirus involves a combination of biosecurity measures, vaccination, and management practices. Biosecurity measures aim to prevent the introduction and spread of the virus into poultry flocks by limiting contact with contaminated materials and people. Vaccination is an effective way to protect commercial poultry from Avian pneumovirus and is routinely used in many countries. Different types of vaccines are available, including live attenuated, inactivated, subunit, and vectored vaccines. Management practices, such as adequate ventilation, nutrition, and sanitation, can also reduce the impact of the disease and improve bird health.

In conclusion, Avian pneumovirus is a significant respiratory pathogen of poultry that can cause clinical disease and economic losses. The virus belongs to the family Pneumoviridae and encodes nine genes, including the essential G and F glycoproteins. The virus can infect various bird species and is transmitted via direct or indirect contact. Diagnosis relies on clinical signs, histopathology, serology, and molecular methods. Control involves biosecurity measures, vaccination, and management practices.

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