Tritrichomonas suis lipophosphoglycan (LPG) antibody and antigen (recombinant protein)

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Diagnostic anti-Tritrichomonas suis lipophosphoglycan (LPG) antibodies pairs and antigen for animal health (animal Cat/Feline, Bovines/Cattle infectious disease tritrichomonosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P235-Tg001-Ag01	Recombinant Tritrichomonas suis lipophosphoglycan (LPG) protein	$3090.00
GMP-VT-P235-Tg001-Ab01	Anti-Tritrichomonas suis lipophosphoglycan (LPG) mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P235-Tg001-Ab02	Anti-Tritrichomonas suis lipophosphoglycan (LPG) mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P235-Tg001-Ab03	Anti-Tritrichomonas suis lipophosphoglycan (LPG) human monoclonal antibody (mAb)	$3090.00
GMP-VT-P235-Tg001-Ab04	Anti-Tritrichomonas suis lipophosphoglycan (LPG) human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P235-Tg001-Ag01
Product Name	Recombinant Tritrichomonas suis lipophosphoglycan (LPG) protein
Pathogen	Tritrichomonas suis
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Tritrichomonas suis lipophosphoglycan (LPG) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Tritrichomonas suis level test of animal Cat/Feline, Bovines/Cattle infectious disease with tritrichomonosis.
Tag	His
Product description	Recombinant Tritrichomonas suis lipophosphoglycan (LPG) proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P235-Tg001-Ab01,GMP-VT-P235-Tg001-Ab02
Pathogen	Tritrichomonas suis
Product Name	Anti-Tritrichomonas suis lipophosphoglycan (LPG) mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Tritrichomonas suis lipophosphoglycan (LPG) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Tritrichomonas suis antibodies in Tritrichomonas suis level test of animal Cat/Feline, Bovines/Cattle infectious disease with tritrichomonosis.
Product description	Anti-Tritrichomonas suis lipophosphoglycan (LPG) mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Tritrichomonas suis antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P235-Tg001-Ab03,GMP-VT-P235-Tg001-Ab04
Pathogen	Tritrichomonas suis
Product Name	Anti-Tritrichomonas suis lipophosphoglycan (LPG) human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Tritrichomonas suis lipophosphoglycan (LPG) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Tritrichomonas suis antibodies in Tritrichomonas suis level test of animal Cat/Feline, Bovines/Cattle infectious disease with tritrichomonosis.
Product description	Anti-Tritrichomonas suis lipophosphoglycan (LPG) mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Tritrichomonas suis, a flagellated protozoan parasite, has been recognized as the causative agent of porcine intestinal spirochetosis (PIS), a condition that severely affects the digestive system of pigs. PIS is a significant economic burden for the pig farming industry worldwide, causing severe morbidity, mortality, and reduced growth rate in affected animals.

Tritrichomonas suis belongs to the family Trichomonadida, which comprises anaerobic flagellated unicellular eukaryotic parasites that inhabit the digestive systems of various vertebrates, including humans. The pathogen's main mode of transmission occurs through the fecal-oral route, where infected pigs shed the parasite's cysts in their feces. Other risk factors for Tritrichomonas suis infections include crowding, poor hygiene, and contaminated feed and water sources.

The morphology of Tritrichomonas suis is characterized by a pear-shaped body approximately 6-18 µm long and 2-7 µm wide. The parasite has three anterior flagella and a single posterior flagellum that protrudes from the cytostome, which serves as the mouth. The flagella facilitate motility, attachment, and feeding of the parasite on the mucosal lining of the pig's large intestine.

The pathogenesis of PIS is not fully understood, but it is thought to involve the parasite's adhesion to the intestinal epithelium, followed by the secretion of toxins that damage the epithelial cells and lead to inflammation. The resulting clinical signs of PIS include diarrhea, weight loss, reduced growth rate, and colitis, which can range from mild to severe, depending on the infection level. In severe cases, PIS can lead to dehydration, anemia, and even death.

Various diagnostic methods are used to identify Tritrichomonas suis infections in pigs, including microscopy, culture, and molecular techniques such as PCR. While microscopy is a rapid and inexpensive method of diagnosis, molecular methods can detect low levels of the pathogen with higher sensitivity and specificity. PCR-based assays targeting the 18S rRNA gene or the ITS region have been shown to be effective for the detection of Tritrichomonas suis in fecal samples.

The treatment of PIS infections in pigs mainly involves the use of antibiotics such as tiamulin, tylosin, and metronidazole. However, the effectiveness of these treatments remains variable, and there are concerns regarding the development of antibiotic resistance in Tritrichomonas suis populations. Therefore, alternative treatments such as probiotics, immunomodulators, and herbal remedies are being investigated as potential therapeutic options.

In conclusion, Tritrichomonas suis is an important pathogen that causes porcine intestinal spirochetosis in pigs. The pathogen's morphology, mode of transmission, and diagnostic methods have been increasingly elucidated, leading to the development of better strategies for the prevention, control, and treatment of PIS. However, more research is needed to understand the pathogenesis of PIS fully and to identify new treatment options that can mitigate the economic impact of this disease on the global pig farming industry.

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