Klebsiella pneumoniae antibody and antigen (recombinant protein)

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Diagnostic anti-Klebsiella pneumoniae antibodies pairs and antigen for animal health (animal Cat/Feline, Dog/Canine, Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry, Deer infectious disease pneumonia, bloodstream infections, wound or surgical site infections, and meningitis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P243-Tg001-Ag01	Recombinant Klebsiella pneumoniae protein	$3090.00
GMP-VT-P243-Tg001-Ab01	Anti-Klebsiella pneumoniae mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P243-Tg001-Ab02	Anti-Klebsiella pneumoniae mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P243-Tg001-Ab03	Anti-Klebsiella pneumoniae human monoclonal antibody (mAb)	$3090.00
GMP-VT-P243-Tg001-Ab04	Anti-Klebsiella pneumoniae human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P243-Tg001-Ag01
Product Name	Recombinant Klebsiella pneumoniae protein
Pathogen	Klebsiella pneumoniae
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Klebsiella pneumoniae antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Klebsiella pneumoniae level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry, Deer infectious disease with pneumonia, bloodstream infections, wound or surgical site infections, and meningitis.
Tag	His
Product description	Recombinant Klebsiella pneumoniae proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P243-Tg001-Ab01,GMP-VT-P243-Tg001-Ab02
Pathogen	Klebsiella pneumoniae
Product Name	Anti-Klebsiella pneumoniae mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Klebsiella pneumoniae antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Klebsiella pneumoniae antibodies in Klebsiella pneumoniae level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry, Deer infectious disease with pneumonia, bloodstream infections, wound or surgical site infections, and meningitis.
Product description	Anti-Klebsiella pneumoniae mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Klebsiella pneumoniae antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P243-Tg001-Ab03,GMP-VT-P243-Tg001-Ab04
Pathogen	Klebsiella pneumoniae
Product Name	Anti-Klebsiella pneumoniae human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Klebsiella pneumoniae antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Klebsiella pneumoniae antibodies in Klebsiella pneumoniae level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry, Deer infectious disease with pneumonia, bloodstream infections, wound or surgical site infections, and meningitis.
Product description	Anti-Klebsiella pneumoniae mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Klebsiella pneumoniae is a bacterial pathogen that is known to cause a range of infections in humans and animals. K. pneumoniae belongs to the family Enterobacteriaceae, which is a group of Gram-negative bacteria that are commonly found in the gut microbiota of humans and animals. The genus Klebsiella includes several species, but K. pneumoniae is the most clinically relevant species.

K. pneumoniae is a facultative anaerobic bacterium, which means it can survive in both aerobic and anaerobic conditions. It is a non-spore-forming, lactose-fermenting, and oxidase-negative bacteria. K. pneumoniae is characterized by its capsule polysaccharides, which play a critical role in immune evasion and virulence. The capsule polysaccharide also protects the bacterium from antimicrobial agents such as antibiotics and disinfectants.

The genome of K. pneumoniae consists of chromosomal DNA that encodes various virulence factors such as lipopolysaccharides, fimbriae, and iron acquisition systems. These virulence factors help K. pneumoniae colonize and infect host tissues. One of the key proteins involved in infection is outer membrane protein A (OmpA), which is responsible for adherence to host cells. The most common type of K. pneumoniae infection is hospital-acquired pneumonia, which is associated with high mortality rates.

Apart from pneumonia, K. pneumoniae can cause other infections such as urinary tract infections, sepsis, and wound infections. Urinary tract infections caused by K. pneumoniae are common in elderly people and patients with underlying medical conditions such as diabetes and kidney disease. Sepsis is a life-threatening condition that occurs when the bacterium enters the bloodstream and triggers an overwhelming immune response. Wound infections caused by K. pneumoniae are common in patients with surgical wounds or traumatic injuries.

The diagnosis of K. pneumoniae infections is usually based on clinical symptoms and laboratory tests. Culture-based methods are commonly used to isolate the bacterium from clinical specimens such as blood, urine, and sputum. Once isolated, K. pneumoniae can be identified by its characteristic morphology, staining properties, and biochemical reactions. However, culture-based methods are time-consuming and may not be sensitive enough to detect low levels of bacteria.

Microscopy can be used to visualize the morphology and structure of K. pneumoniae. Gram staining is a common microscopy technique that can differentiate between Gram-positive and Gram-negative bacteria. K. pneumoniae is a Gram-negative bacterium that appears as a rod-shaped cell under the microscope.

Nucleic acid amplification tests (NAATs) such as polymerase chain reaction (PCR) assays can also be used to detect K. pneumoniae. NAATs can target specific genes or regions of the genome, which allows for rapid and sensitive detection of the bacterium. For example, PCR assays can target the 16S rRNA gene, which is a conserved gene present in all bacteria. Additionally, PCR assays can target genes that are specific to K. pneumoniae, such as the magA gene, which is involved in the biosynthesis of K1 capsular polysaccharide.

Serological assays that detect the presence of antibodies against K. pneumoniae proteins such as OmpA or capsular polysaccharides can also be used for diagnosis. Serological assays are based on the principle of antigen-antibody reactions, which allows for the detection of specific molecules in patient samples such as blood or urine.

In conclusion, K. pneumoniae is a clinically relevant bacterial pathogen that can cause a range of infections in humans and animals. The bacterium is characterized by its capsule polysaccharides, which play a critical role in immune evasion and virulence. Diagnosis of K. pneumoniae infections is usually based on clinical symptoms and laboratory tests such as culture-based methods, microscopy, NAATs, and serological assays.

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