Pestivirus antibody and antigen (recombinant protein)

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Diagnostic anti-Pestivirus antibodies pairs and antigen for animal health (animal Cat/Feline, Dog/Canine, Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry, Deer infectious disease diarrhoea and respiratory disease) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P247-Tg001-Ag01	Recombinant Pestivirus protein	$3090.00
GMP-VT-P247-Tg001-Ab01	Anti-Pestivirus mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P247-Tg001-Ab02	Anti-Pestivirus mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P247-Tg001-Ab03	Anti-Pestivirus human monoclonal antibody (mAb)	$3090.00
GMP-VT-P247-Tg001-Ab04	Anti-Pestivirus human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P247-Tg001-Ag01
Product Name	Recombinant Pestivirus protein
Pathogen	Pestivirus
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Pestivirus antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Pestivirus level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry, Deer infectious disease with diarrhoea and respiratory disease.
Tag	His
Product description	Recombinant Pestivirus proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P247-Tg001-Ab01,GMP-VT-P247-Tg001-Ab02
Pathogen	Pestivirus
Product Name	Anti-Pestivirus mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Pestivirus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Pestivirus antibodies in Pestivirus level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry, Deer infectious disease with diarrhoea and respiratory disease.
Product description	Anti-Pestivirus mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Pestivirus antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P247-Tg001-Ab03,GMP-VT-P247-Tg001-Ab04
Pathogen	Pestivirus
Product Name	Anti-Pestivirus human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Pestivirus antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Pestivirus antibodies in Pestivirus level test of animal Cat/Feline, Dog/Canine, Bovines/Cattle, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry, Deer infectious disease with diarrhoea and respiratory disease.
Product description	Anti-Pestivirus mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Pestivirus is a member of the Flaviviridae family, which also includes several other important human and animal pathogens such as yellow fever virus, dengue virus, West Nile virus, and Zika virus. Pestiviruses are known to cause significant economic losses in the livestock industry due to their ability to infect various domestic and wild ruminants and swine.

Pestiviruses have a simple structure, consisting of a single-stranded RNA genome of approximately 12.3 kb that is enclosed within an icosahedral capsid and a host-derived lipid envelope. The genome is made up of a single open reading frame (ORF) flanked by 5' and 3' untranslated regions (UTRs). The ORF encodes a large polyprotein that is cleaved into individual non-structural and structural proteins by viral and host proteases.

The non-structural proteins play crucial roles in viral replication and pathogenesis, including viral RNA synthesis, evasion of host immune defenses, and hijacking of host cellular machinery. The structural proteins, including glycoproteins E1 and E2, are responsible for viral entry into host cells and assembly of virions. The glycoproteins form heterodimers that are involved in viral attachment to host cell receptors and subsequent fusion with host cell membranes, leading to the establishment of viral infection.

Many different pestivirus strains have been identified in various parts of the world. Bovine viral diarrhea virus (BVDV) is the most well-known pestivirus and is divided into two biotypes: cytopathic and non-cytopathic. Cytopathic BVDV causes severe disease in cattle, while non-cytopathic strains evade immune detection and can lead to persistent infection and immunotolerance in infected animals. Classical swine fever virus (CSFV), also known as hog cholera virus, infects domestic and wild swine and can cause severe hemorrhagic disease.

Pestivirus infections can lead to a range of clinical signs and symptoms depending on the host species, immune status, and the strain virulence. Infection in cattle can cause a variety of clinical manifestations including fever, diarrhea, respiratory distress, abortions, and congenital malformations. In sheep and goats, pestivirus infection can lead to chronic wasting, growth retardation, and reproductive failure. Classical swine fever can cause severe acute or chronic disease, with symptoms including high fever, lethargy, anorexia, vomiting, and hemorrhage.

Diagnostic methods for pestivirus include ELISA, PCR, and virus isolation. ELISA is a serological test that detects antibodies against specific viral antigens. PCR is a molecular diagnostic tool that targets viral nucleic acids in clinical samples such as blood, serum, or tissue. Virus isolation involves culturing the virus in cell culture, followed by detection using various techniques such as immunofluorescence or ELISA. Detection methods target various viral proteins such as the RNA polymerase gene, NS3, and glycoproteins E1 and E2.

In conclusion, Pestivirus is a significant animal pathogen that can cause severe economic losses and public health threats. The virus has a simple structure, consisting of a single-stranded RNA genome and structural and non-structural proteins. The virus can infect a range of host species, leading to a broad spectrum of clinical manifestations. A variety of diagnostic methods are available for detecting Pestivirus infection, including ELISA, PCR, and virus isolation.

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