Mycobacterium avium SahH (M70S) antibody and antigen (recombinant protein)

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Diagnostic anti-Mycobacterium avium SahH (M70S) antibodies pairs and antigen for animal health (animal Cat/Feline, Dog/Canine, Rabbit, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Swine/Porcine/Pig infectious disease tuberculosis) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P249-Tg001-Ag01	Recombinant Mycobacterium avium SahH (M70S) protein	$3090.00
GMP-VT-P249-Tg001-Ab01	Anti-Mycobacterium avium SahH (M70S) mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P249-Tg001-Ab02	Anti-Mycobacterium avium SahH (M70S) mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P249-Tg001-Ab03	Anti-Mycobacterium avium SahH (M70S) human monoclonal antibody (mAb)	$3090.00
GMP-VT-P249-Tg001-Ab04	Anti-Mycobacterium avium SahH (M70S) human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P249-Tg001-Ag01
Product Name	Recombinant Mycobacterium avium SahH (M70S) protein
Pathogen	Mycobacterium avium
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Mycobacterium avium SahH (M70S) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Mycobacterium avium level test of animal Cat/Feline, Dog/Canine, Rabbit, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Swine/Porcine/Pig infectious disease with tuberculosis.
Tag	His
Product description	Recombinant Mycobacterium avium SahH (M70S) proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P249-Tg001-Ab01,GMP-VT-P249-Tg001-Ab02
Pathogen	Mycobacterium avium
Product Name	Anti-Mycobacterium avium SahH (M70S) mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Mycobacterium avium SahH (M70S) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Mycobacterium avium antibodies in Mycobacterium avium level test of animal Cat/Feline, Dog/Canine, Rabbit, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Swine/Porcine/Pig infectious disease with tuberculosis.
Product description	Anti-Mycobacterium avium SahH (M70S) mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Mycobacterium avium antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P249-Tg001-Ab03,GMP-VT-P249-Tg001-Ab04
Pathogen	Mycobacterium avium
Product Name	Anti-Mycobacterium avium SahH (M70S) human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Mycobacterium avium SahH (M70S) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Mycobacterium avium antibodies in Mycobacterium avium level test of animal Cat/Feline, Dog/Canine, Rabbit, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Swine/Porcine/Pig infectious disease with tuberculosis.
Product description	Anti-Mycobacterium avium SahH (M70S) mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Mycobacterium avium is one of the Mycobacterium avium-intracellulare complex (MAC) species. MAC is a group of bacteria that includes Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium chimaera. These bacteria are known as opportunistic pathogens, meaning they typically cause infection in people with weakened immune systems, such as those with HIV/AIDS or individuals undergoing immunosuppressive therapy.

Mycobacterium avium can be found in the environment, most commonly in soil, dust, and water. It can enter the human body through ingestion, inhalation, or skin contact with contaminated sources. Once it enters the body, it invades the immune cells called macrophages and reproduces within them, leading to persistent infections.

The cell wall of Mycobacterium avium has a unique structure that sets it apart from many other bacteria. Its cell wall contains a thick layer of peptidoglycan, arabinogalactan, and mycolic acids, which makes it resistant to many types of antibiotics and disinfectants. Additionally, Mycobacterium avium has a complex genome consisting of a single circular chromosome and multiple plasmids that encode various virulence factors. One important factor is the ESAT-6 protein, which is involved in the evasion of host immune responses and the invasion of host cells.

Mycobacterium avium infections primarily affect the respiratory and gastrointestinal tracts. In humans, it can cause chronic lung diseases such as bronchiectasis or nodular/bronchiolar disease. The symptoms of this condition include coughing, shortness of breath, fatigue, fever, and weight loss. In patients with AIDS, disseminated Mycobacterium avium complex infection may occur, affecting various organs and causing symptoms such as fever, night sweats, anemia, and weight loss. Mycobacterium avium can also cause lymphadenitis, an inflammation of the lymph nodes that typically affects children and is characterized by swelling, redness, and tenderness.

There are several diagnostic methods for detecting Mycobacterium avium infections. NAATs have proven useful in identifying MAC species from clinical samples such as blood, sputum, and stool. These tests selectively target specific genes, such as the IS901 element, found only in MAC bacteria. Acid-fast staining, which reveals the presence of mycolic acids in the bacterial cell wall, is another common diagnostic method. Additionally, culture-based methods are used to isolate and grow the pathogen from clinical samples. Serological assays and imaging techniques like chest X-rays are also helpful in the diagnosis of Mycobacterium avium infections.

The treatment of Mycobacterium avium infections is challenging because of its complex cell wall structure and resistance to many antibiotics. The standard therapy regimen consists of a combination of macrolide antibiotics such as clarithromycin or azithromycin, along with ethambutol and rifabutin. Treatment may last for several months to a year depending on the nature and severity of the infection. In patients with AIDS, antiretroviral therapy may be necessary to improve immunity and prevent recurrent infections.

In conclusion, Mycobacterium avium is a complex and challenging pathogen that can cause serious infections in humans, particularly those with weakened immune systems. Its unique cell wall structure, genomic characteristics, and virulence factors make it highly resistant to antibiotics and difficult to treat. Proper diagnosis and management of Mycobacterium avium infections require a comprehensive strategy that includes effective diagnostic methods, antimicrobial therapy, and supportive care.

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