Candida tropicalis Lanosterol 14-alpha demethylase(ERG11) antibody and antigen (recombinant protein)

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Diagnostic anti-Candida tropicalis Lanosterol 14-alpha demethylase(ERG11) antibodies pairs and antigen for animal health (animal Cat/Feline, Dog/Canine, Rabbit, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry infectious disease Candidemia) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-VT-P271-Tg001-Ag01	Recombinant Candida tropicalis Lanosterol 14-alpha demethylase(ERG11) protein	$3090.00
GMP-VT-P271-Tg001-Ab01	Anti-Candida tropicalis Lanosterol 14-alpha demethylase(ERG11) mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P271-Tg001-Ab02	Anti-Candida tropicalis Lanosterol 14-alpha demethylase(ERG11) mouse monoclonal antibody (mAb)	$3090.00
GMP-VT-P271-Tg001-Ab03	Anti-Candida tropicalis Lanosterol 14-alpha demethylase(ERG11) human monoclonal antibody (mAb)	$3090.00
GMP-VT-P271-Tg001-Ab04	Anti-Candida tropicalis Lanosterol 14-alpha demethylase(ERG11) human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-VT-P271-Tg001-Ag01
Product Name	Recombinant Candida tropicalis Lanosterol 14-alpha demethylase(ERG11) protein
Pathogen	Candida tropicalis
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Candida tropicalis Lanosterol 14-alpha demethylase(ERG11) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Candida tropicalis level test of animal Cat/Feline, Dog/Canine, Rabbit, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry infectious disease with Candidemia.
Tag	His
Product description	Recombinant Candida tropicalis Lanosterol 14-alpha demethylase(ERG11) proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P271-Tg001-Ab01,GMP-VT-P271-Tg001-Ab02
Pathogen	Candida tropicalis
Product Name	Anti-Candida tropicalis Lanosterol 14-alpha demethylase(ERG11) mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Candida tropicalis Lanosterol 14-alpha demethylase(ERG11) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Candida tropicalis antibodies in Candida tropicalis level test of animal Cat/Feline, Dog/Canine, Rabbit, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry infectious disease with Candidemia.
Product description	Anti-Candida tropicalis Lanosterol 14-alpha demethylase(ERG11) mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Candida tropicalis antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-VT-P271-Tg001-Ab03,GMP-VT-P271-Tg001-Ab04
Pathogen	Candida tropicalis
Product Name	Anti-Candida tropicalis Lanosterol 14-alpha demethylase(ERG11) human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Candida tropicalis Lanosterol 14-alpha demethylase(ERG11) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Candida tropicalis antibodies in Candida tropicalis level test of animal Cat/Feline, Dog/Canine, Rabbit, Bovines/Cattle, Equine/Horse, Ovines/Sheep, Caprine/Goat, Fish, Swine/Porcine/Pig, Avian/Bird/Poultry infectious disease with Candidemia.
Product description	Anti-Candida tropicalis Lanosterol 14-alpha demethylase(ERG11) mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Pathogen Information

Candida tropicalis is a medically significant fungal pathogen that has increasingly become recognized for its potential to cause various infections in humans. It is part of a larger family of yeasts and molds known as Candida, which includes several other species responsible for human disease. Candida species are commonly found on the skin and mucous membranes of healthy individuals but can emerge as opportunistic infectious agents.

Candida tropicalis belongs to the class Saccharomycetes, subphylum Dikaryomycota, and phylum Ascomycota. This classification is based on the organism's structure, life cycle, and reproductive strategies. Candida tropicalis reproduces by budding and can form pseudohyphae, which are elongated structures consisting of connected yeast cells. Its optimal growth temperature ranges from 30-40°C, similar to that of the human body, and it tolerates a wide range of pH levels.

The cell wall of Candida tropicalis is a dynamic and complex structure that is crucial for maintaining cellular integrity and defending against environmental stressors. Additionally, it aids in adherence to host tissues, evasion from host immune defenses, and acquisition of essential nutrients. Chitin, one of the primary components of the cell wall, is synthesized by chitin synthase enzymes encoded by CHS genes. In Candida tropicalis, chitin synthesis is regulated by multiple factors, including transcription factors, signal transduction pathways, and nutrient availability.

Apart from chitin, Candida tropicalis possesses several additional virulence factors. The expression of these factors is modulated by various regulators, including transcription factors, signaling pathways, epigenetic modifications, and post-transcriptional modifications. For instance, glucanases, proteases, and lipases are involved in cell wall remodeling and nutrient acquisition and play critical roles in the adhesion, invasion, and damage of host tissues. These factors also contribute to the evasion of host immune defenses by interfering with chemotaxis, phagocytosis, complement activation, and cytokine production.

Candida tropicalis infections in humans have been reported worldwide and are a growing concern, especially in immunocompromised individuals and those with underlying medical conditions such as diabetes, HIV, and cancer. Candidemia, a bloodstream infection caused by Candida species, is one of the most severe manifestations of Candida tropicalis infections. It can cause high fever, chills, hypotension, and multi-organ failure and has a high mortality rate if not treated promptly.

Other common types of Candida tropicalis infections include urinary tract infections, gastrointestinal infections, and skin and soft tissue infections, often arising from central venous catheters, surgical wounds, and burns. The presence of Candida tropicalis in these niches is usually indicative of invasive disease and may require removal or replacement of infected medical devices, rigorous antimicrobial therapy, or surgery.

Diagnostic methods for Candida tropicalis infections rely on both culture-based and molecular-based techniques. Blood culture and urine culture are the gold standard for detecting Candida tropicalis in clinical specimens. However, these methods can take several days to weeks to yield results, and they have varying degrees of sensitivity and specificity. Molecular-based techniques, such as PCR and DNA sequencing, have emerged as promising alternatives for rapid, accurate, and sensitive detection of Candida tropicalis. PCR assays targeting conserved regions of the fungal genome, including 18S rDNA, ITS region, and D1/D2 region of 28S rDNA, have shown particular promise in detecting Candida tropicalis infections in various clinical samples.

In conclusion, Candida tropicalis is a medically important yeast that can cause a range of infections in humans. Its virulence is associated with several factors, including complex cell wall composition, diverse proteinases and lipases, and evasion of host immune responses. Accurate diagnosis of Candida tropicalis infections is critical for effective treatment and management of patients, and molecular-based techniques have shown particular promise in providing rapid and sensitive detection of the pathogen.

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