β-isomerized C-terminal telopeptides (β-CTx) antibody and antigen (Recombinant protein)

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Diagnostic β-isomerized C-terminal telopeptides (β-CTx) antibodies (anti-β-isomerized C-terminal telopeptides, anti-β-CTx) and antigens (recombinant β-isomerized C-terminal telopeptides (β-CTx) protein) for Metabolic diseases β-CTx detection in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT.

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-h-CTx-Ag01	Recombinant human β-CTx Protein	$3090.00
GMP-h-CTx-Ab01	Anti-human β-CTx mouse monoclonal antibody (mAb)	$1953.00
GMP-h-CTx-Ab02	Anti-human β-CTx mouse monoclonal antibody (mAb)	$1953.00
GMP-h-CTx-Ab03	Anti-human β-CTx human monoclonal antibody (mAb)	$1953.00
GMP-h-CTx-Ab04	Anti-human β-CTx human monoclonal antibody (mAb)	$1953.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Pruducts	GMP-h-CTx-Ag01
Product Name	Recombinant human β-CTx Protein
Target/Biomarker	β-isomerized C-terminal telopeptides (β-CTx)
Alias of Target/Biomarker	#N/A
Expression platform	mammalian
Isotypes	Recombinant Antigen
Bioactivity validation	β-isomerized C-terminal telopeptides (β-CTx) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in β-CTx level test of Metabolic diseases (osteoporosis) and related syndrome evaluation
Products description	Recombinant Human β-isomerized C-terminal telopeptides (β-CTx) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Pruducts	GMP-h-CTx-Ab01,GMP-h-CTx-Ab02
Product Name	Anti-human β-CTx mouse monoclonal antibody (mAb)
Target/Biomarker	β-isomerized C-terminal telopeptides (β-CTx)
Alias of Target/Biomarker	#N/A
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Human β-isomerized C-terminal telopeptides (β-CTx) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other β-isomerized C-terminal telopeptides (β-CTx) antibodies in β-CTx level test of Metabolic diseases (osteoporosis) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human β-CTx mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other β-isomerized C-terminal telopeptides (β-CTx) antibodies.
Reconized/Reactive Species	Human
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Pruducts	GMP-h-CTx-Ab03,GMP-h-CTx-Ab04
Product Name	Anti-human β-CTx human monoclonal antibody (mAb)
Target/Biomarker	β-isomerized C-terminal telopeptides (β-CTx)
Alias of Target/Biomarker	#N/A
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Human β-isomerized C-terminal telopeptides (β-CTx) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other β-isomerized C-terminal telopeptides (β-CTx) antibodies in β-CTx level test of Metabolic diseases (osteoporosis) and related syndrome evaluation.
Tag	hFc
Products description	Anti-human β-CTx mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Reconized/Reactive Species	Human
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Figure 1. GeneMedi's GMP-h-β-CTx-Ab01/02/03/04 (Anti-human β-CTx mouse monoclonal antibody) are validated to detect the GMP-h-β-CTx-Ag01 (Recombinant human β-CTx Protein) in ELISA.

   EC50 [Ab01 (capture)-Ab02 (detect) ]= 271.3 ppb;

   EC50 [Ab01 (capture)-Ab04 (detect)]= 614.8 ppb;

   EC50 [Ab03 (capture)-Ab02 (detect) ]= 363.5 ppb;

   EC50 [Ab03 (capture)-Ab04 (detect) ]= 811.8 ppb.

Click to get more Data / Case study about the product.

Target/Biomarker information

Bone is a metabolically active tissue, and almost 10% of the human adult bone is remodeled every year. Bone remodeling comprises bone resorption and formation. During the remodeling process, the activity of osteoblasts and osteoclasts results in the release of proteins or peptides. The peptide products are either proteins released by the cells, such as bone-specific alkaline phosphatase (BAP) and osteocalcin (OC) or degradation products of cellular activity, such as urinary hydroxyproline, deoxypyridinoline, β-isomerized C-terminal telopeptides (β-CTx), total procollagen type 1 amino-terminal propeptide (tP1NP), etc [14]. The measurement of these clinical biomarkers, categorized as biochemical bone markers, in serum and urine is widely used as a rapid means to monitor cellular activity of bone [15]. β-CTx and other substances that originate during bone resorption are called bone resorption markers, while tP1NP, BAP, and OC, which are generated from bone reconstruction, are called bone formation markers.

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