soluble fragment of cytokeratin-19 (CYFRA21-1) antibody and antigen (Recombinant protein)

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Diagnostic soluble fragment of cytokeratin-19 (CYFRA21-1) antibodies (anti-soluble fragment of cytokeratin-19, anti-CYFRA21-1) and antigens (recombinant soluble fragment of cytokeratin-19 (CYFRA21-1) protein) for Cancer CYFRA21-1 detection in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT.

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-h-CYFRA21-1-Ag01	Recombinant human CYFRA21-1 Protein	$3090.00
GMP-h-CYFRA21-1-Ab01	Anti-human CYFRA21-1 mouse monoclonal antibody (mAb)	$1953.00
GMP-h-CYFRA21-1-Ab02	Anti-human CYFRA21-1 mouse monoclonal antibody (mAb)	$1953.00
GMP-h-CYFRA21-1-Ab03	Anti-human CYFRA21-1 human monoclonal antibody (mAb)	$1953.00
GMP-h-CYFRA21-1-Ab04	Anti-human CYFRA21-1 human monoclonal antibody (mAb)	$1953.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Pruducts	GMP-h-CYFRA21-1-Ag01
Product Name	Recombinant human CYFRA21-1 Protein
Target/Biomarker	soluble fragment of cytokeratin-19 (CYFRA21-1)
Alias of Target/Biomarker	#N/A
Expression platform	mammalian
Isotypes	Recombinant Antigen
Bioactivity validation	soluble fragment of cytokeratin-19 (CYFRA21-1) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in CYFRA21-1 level test of Cancer (bronchopulmonary dysplasia) and related syndrome evaluation
Products description	Recombinant Human soluble fragment of cytokeratin-19 (CYFRA21-1) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Pruducts	GMP-h-CYFRA21-1-Ab01,GMP-h-CYFRA21-1-Ab02
Product Name	Anti-human CYFRA21-1 mouse monoclonal antibody (mAb)
Target/Biomarker	soluble fragment of cytokeratin-19 (CYFRA21-1)
Alias of Target/Biomarker	#N/A
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Human soluble fragment of cytokeratin-19 (CYFRA21-1) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other soluble fragment of cytokeratin-19 (CYFRA21-1) antibodies in CYFRA21-1 level test of Cancer (bronchopulmonary dysplasia) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human CYFRA21-1 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other soluble fragment of cytokeratin-19 (CYFRA21-1) antibodies.
Reconized/Reactive Species	Human
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Pruducts	GMP-h-CYFRA21-1-Ab03,GMP-h-CYFRA21-1-Ab04
Product Name	Anti-human CYFRA21-1 human monoclonal antibody (mAb)
Target/Biomarker	soluble fragment of cytokeratin-19 (CYFRA21-1)
Alias of Target/Biomarker	#N/A
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Human soluble fragment of cytokeratin-19 (CYFRA21-1) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other soluble fragment of cytokeratin-19 (CYFRA21-1) antibodies in CYFRA21-1 level test of Cancer (bronchopulmonary dysplasia) and related syndrome evaluation.
Tag	hFc
Products description	Anti-human CYFRA21-1 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Reconized/Reactive Species	Human
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

CYRFA 21-1 (cytokeratin 19 fragment) has been demonstrated as clinically useful in the prognostication and monitoring of non-small cell lung cancer (NSCLC). Elevated pretreatment levels may be associated with unfavorable prognosis, and decreasing levels during therapy predict an objective response to treatment. CYFRA 21–1 is a cytoplasmic protein fragment of cytokeratin 19 (CK-19) which is found in various epithelial malignancies, such as lung cancer[, gastrointestinal cancer and cervical cancer. This soluble debris can be released into the blood after tumor cell death, thus exhibiting a close relationship with tumor cell necrosis. Its level could be a proper indicator of necrosis degree. It has been reported that CYFRA 21–1 is a potential tumor marker for the diagnosis and prognosis of non-small cell lung cancer (NSCLC) and squamous carcinoma of the head and neck. Other studies have confirmed that the serum CYFRA 21–1 level before treatment is related to poor prognosis in patients with non-metastatic head and neck cancer(HNC).

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