Cystatin C (CYSC) antibody and antigen (Recombinant protein)

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Diagnostic Cystatin C (CYSC) antibodies (anti-Cystatin C, anti-CYSC) and antigens (recombinant Cystatin C (CYSC) protein) for Kidney function (renal damages) CYSC detection in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT.

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-h-CYSC-Ag01	Recombinant human CYSC Protein	$3090.00
GMP-h-CYSC-Ab01	Anti-human CYSC mouse monoclonal antibody (mAb)	$1953.00
GMP-h-CYSC-Ab02	Anti-human CYSC mouse monoclonal antibody (mAb)	$1953.00
GMP-h-CYSC-Ab03	Anti-human CYSC human monoclonal antibody (mAb)	$1953.00
GMP-h-CYSC-Ab04	Anti-human CYSC human monoclonal antibody (mAb)	$1953.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Pruducts	GMP-h-CYSC-Ag01
Product Name	Recombinant human CYSC Protein
Target/Biomarker	Cystatin C (CYSC)
Alias of Target/Biomarker	ARMD11, HEL-S-2, CST3
Expression platform	mammalian
Isotypes	Recombinant Antigen
Bioactivity validation	Cystatin C (CYSC) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in CYSC level test of Kidney function (renal damages) (kidney function (renal damages)) and related syndrome evaluation
Products description	Recombinant Human Cystatin C (CYSC) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Pruducts	GMP-h-CYSC-Ab01,GMP-h-CYSC-Ab02
Product Name	Anti-human CYSC mouse monoclonal antibody (mAb)
Target/Biomarker	Cystatin C (CYSC)
Alias of Target/Biomarker	ARMD11, HEL-S-2, CST3
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Human Cystatin C (CYSC) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Cystatin C (CYSC) antibodies in CYSC level test of Kidney function (renal damages) (kidney function (renal damages)) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human CYSC mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other Cystatin C (CYSC) antibodies.
Reconized/Reactive Species	Human
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Pruducts	GMP-h-CYSC-Ab03,GMP-h-CYSC-Ab04
Product Name	Anti-human CYSC human monoclonal antibody (mAb)
Target/Biomarker	Cystatin C (CYSC)
Alias of Target/Biomarker	ARMD11, HEL-S-2, CST3
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Human Cystatin C (CYSC) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Cystatin C (CYSC) antibodies in CYSC level test of Kidney function (renal damages) (kidney function (renal damages)) and related syndrome evaluation.
Tag	hFc
Products description	Anti-human CYSC mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Reconized/Reactive Species	Human
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Cystatin C (CysC) is a relatively small protein that is produced throughout the body by all cells that contain a nucleus and is found in a variety of body fluids, including the blood. It is produced, filtered from the blood by the kidneys, and broken down at a constant rate. This test measures the amount of cystatin C in blood to help evaluate kidney function. Cystatin C (CysC) is filtered out of the blood by the glomeruli, clusters of tiny blood vessels in the kidneys that allow water, dissolved substances, and wastes to pass through their walls while retaining blood cells and larger proteins. What passes through the walls of the glomeruli forms a filtrate fluid. From this fluid, the kidneys reabsorb cystatin C, glucose, and other substances. The remaining fluid and wastes are carried to the bladder and excreted as urine. The reabsorbed cystatin C is then broken down and is not returned to the blood. The rate at which the fluid is filtered is called the glomerular filtration rate (GFR). A decline in kidney function leads to decreases in the GFR and to increases in cystatin C and other measures of kidney function, such as creatinine and urea in the blood. The increases in these levels occur because the kidneys are not able to properly filter the blood at a normal rate, causing their accumulation in the blood. On the other hand, improvement in kidney function is expected to lead to increases in GFR, which would cause cystatin C, creatinine, and urea to decline as a result of the kidneys being able to effectively clear them from the blood. When the kidneys are functioning normally, concentrations of cystatin C in the blood are stable. However, as kidney function deteriorates, the concentrations begin to rise. This increase in cystatin C occurs as the GFR falls and is often detectable before there is a measurable decrease in kidney function (GFR). Because cystatin C levels fluctuate with changes in GFR, there has been interest in the CysC blood test as one method of evaluating kidney function. Tests currently used include creatinine, a byproduct of muscle metabolism that is measured in the blood and urine, blood urea nitrogen (BUN), and eGFR (an estimate of the GFR usually calculated from the blood creatinine level). Unlike creatinine, cystatin C is not significantly affected by muscle mass (hence, sex or age), race, or diet, which has led to the idea that it could be a more reliable marker of kidney function and potentially used to generate a more precise estimate of GFR. While there are growing data and literature supporting the use of cystatin C, there is still a degree of uncertainty about when and how it should be used. However, testing is becoming increasingly more available and steps are being taken toward standardizing the calibration of cystatin C results.

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