Heat shock proteins 90-alpha (HSP90

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-h-HSP90-Ag01	Recombinant human HSP90AA1/HSP90	3090
GMP-h-HSP90-Ab01	Anti-human HSP90AA1/HSP90	1953
GMP-h-HSP90-Ab02	Anti-human HSP90AA1/HSP90	1953
GMP-h-HSP90-Ab03	Anti-human HSP90AA1/HSP90	1953
GMP-h-HSP90-Ab04	Anti-human HSP90AA1/HSP90	1953

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Product Description

Cat No. of Products	GMP-h-HSP90-Ag01
Product Name	Recombinant human HSP90AA1/HSP90
Target/Biomarker	Heat shock proteins 90-alpha (HSP90(HSP90)
Alias of Target/Biomarker	EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp103, Hsp89, Hsp90, LAP-2, LAP2
Expression platform	mammalian
Isotypes	Recombinant Antigen
Bioactivity validation	Heat shock proteins 90-alpha (HSP90 (HSP90) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in HSP90 level test of Cancer (renal cancer, liver cancer and breast cancer) and related syndrome evaluation.
Products description	Recombinant human HSP90AA1/HSP90 was expressed in mammalian expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Standard substance, positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-HSP90-Ab01, GMP-h-HSP90-Ab02, GMP-h-HSP90-Ab03, GMP-h-HSP90-Ab04
Product Name	Anti-human HSP90AA1/HSP90
Target/Biomarker	Heat shock proteins 90-alpha (HSP90(HSP90)
Alias of Target/Biomarker	EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp103, Hsp89, Hsp90, LAP-2, LAP2
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Human Heat shock proteins 90-alpha (HSP90 (HSP90) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Heat shock proteins 90-alpha (HSP90 (HSP90) antibodies in HSP90 level test of Cancer (renal cancer, liver cancer and breast cancer) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human HSP90AA1/HSP90 is a monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

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