Procollagen III N-terminal peptide (PIIINP) antibody and antigen (Recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)	First Order Discount	First Order Discount Price
GMP-h-PIIINP-Ag01	Recombinant human COL3A1/PIIINP Protein	3090
GMP-h-PIIINP-Ab01	Anti-human COL3A1/PIIINP mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-h-PIIINP-Ab02	Anti-human COL3A1/PIIINP mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-h-PIIINP-Ab03	Anti-human COL3A1/PIIINP human monoclonal antibody (mAb)	1953	20%	1562.4
GMP-h-PIIINP-Ab04	Anti-human COL3A1/PIIINP human monoclonal antibody (mAb)	1953	20%	1562.4

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Products	GMP-h-PIIINP-Ag01
Product Name	Recombinant human COL3A1/PIIINP Protein
Target/Biomarker	Procollagen III N-terminal peptide (PIIINP)
Alias of Target/Biomarker	EDS4A, EDSVASC, PMGEDSV
Expression platform	mammalian
Isotypes	Recombinant Antigen
Bioactivity validation	Procollagen III N-terminal peptide (PIIINP) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in PIIINP level test of Liver diseases (liver fibrosis and cirrhosis) and related syndrome evaluation.
Tag	His
Products description	Recombinant human COL3A1/PIIINP Protein was synthesized.
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-PIIINP-Ab01, GMP-h-PIIINP-Ab02
Product Name	Anti-human COL3A1/PIIINP mouse monoclonal antibody (mAb)
Target/Biomarker	Procollagen III N-terminal peptide (PIIINP)
Alias of Target/Biomarker	EDS4A, EDSVASC, PMGEDSV
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Procollagen III N-terminal peptide (PIIINP) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in PIIINP level test of Liver diseases (liver fibrosis and cirrhosis) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human COL3A1/PIIINP mouse monoclonal antibody (mAb) was synthesized.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-PIIINP-Ab03, GMP-h-PIIINP-Ab04
Product Name	Anti-human COL3A1/PIIINP human monoclonal antibody (mAb)
Target/Biomarker	Procollagen III N-terminal peptide (PIIINP)
Alias of Target/Biomarker	EDS4A, EDSVASC, PMGEDSV
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Procollagen III N-terminal peptide (PIIINP) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in PIIINP level test of Liver diseases (liver fibrosis and cirrhosis) and related syndrome evaluation.
Tag	hFc
Products description	Anti-human COL3A1/PIIINP human monoclonal antibody (mAb) was synthesized.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Procollagen III N-terminal peptide (PIIINP), also known as Type III procollagen peptide, is a serum marker of collagen turnover and is used to assess hepatic fibrosis in patients on long-term Methotrexate. Background: PIIINP is the amino terminal peptide of type III procollagen, released from the precursor peptide during the synthesis and deposition of type III collagen. PIIINP in the serum can be derived from the synthesis of new type III collagen or from the degradation of existing type III collagen fibrils. There is evidence that serum PIIINP measurement is an effective non-invasive test for the detection and monitoring of Methotrexate-induced liver fibrosis and cirrhosis, and serial measurements may reduce the need for liver biopsy. Dermatology patients with repeated normal levels of PIIINP are very unlikely to have significant liver damage from fibrosis or cirrhosis. Conversely a high serum PIIINP or series of high values may indicate that a liver biopsy is required and in some cases, that Methotrexate should be withdrawn. Note that PIIINP can be raised following bone fracture and also in rheumatology patients as it can be falsely elevated in inflammatory arthritis.

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