Alpha-synuclein (α-synuclein) antibody and antigen (Recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-h-α-synuclein-Ag01	Recombinant human SNCA/α-synuclein/NACP/PARK1 Protein	3090
GMP-h-α-synuclein-Ab01	Anti-human SNCA/α-synuclein/NACP/PARK1 mouse monoclonal antibody (mAb)	1953
GMP-h-α-synuclein-Ab02	Anti-human SNCA/α-synuclein/NACP/PARK1 mouse monoclonal antibody (mAb)	1953
GMP-h-α-synuclein-Ab03	Anti-human SNCA/α-synuclein/NACP/PARK1 human monoclonal antibody (mAb)	1953
GMP-h-α-synuclein-Ab04	Anti-human SNCA/α-synuclein/NACP/PARK1 human monoclonal antibody (mAb)	1953

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Product Description

Cat No. of Products	GMP-h-α-synuclein-Ag01
Product Name	Recombinant human SNCA/α-synuclein/NACP/PARK1 Protein
Target/Biomarker	Alpha-synuclein(α-synuclein)
Alias of Target/Biomarker	NACP, PARK1, PARK4, PD1
Expression platform	synthesized
Isotypes	NA
Bioactivity validation	Alpha-synuclein (α-synuclein) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in α-synuclein level test of Neurodegenerative diseases (Alzheimer Disease (AD),Parkinson's disease(PD)) and related syndrome evaluation.
Products description	Recombinant human SNCA/α-synuclein/NACP/PARK1 Protein was expressed in synthesized expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control,ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and immunonephelometry.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-α-synuclein-Ab01, GMP-h-α-synuclein-Ab02
Product Name	Anti-human SNCA/α-synuclein/NACP/PARK1 mouse monoclonal antibody (mAb)
Target/Biomarker	Alpha-synuclein(α-synuclein)
Alias of Target/Biomarker	NACP, PARK1, PARK4, PD1
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Human Alpha-synuclein (α-synuclein) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Alpha-synuclein (α-synuclein) antibodies in α-synuclein level test of Neurodegenerative diseases (Alzheimer Disease (AD),Parkinson's disease(PD)) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human SNCA/α-synuclein/NACP/PARK1 mouse monoclonal antibody (mAb) is a monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-h-α-synuclein-Ab03, GMP-h-α-synuclein-Ab04
Product Name	Anti-human SNCA/α-synuclein/NACP/PARK1 human monoclonal antibody (mAb)
Target/Biomarker	Alpha-synuclein(α-synuclein)
Alias of Target/Biomarker	NACP, PARK1, PARK4, PD1
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Human Alpha-synuclein (α-synuclein) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Alpha-synuclein (α-synuclein) antibodies in α-synuclein level test of Neurodegenerative diseases (Alzheimer Disease (AD),Parkinson's disease(PD)) and related syndrome evaluation.
Tag	hFc
Products description	Anti-human SNCA/α-synuclein/NACP/PARK1 human monoclonal antibody (mAb) is a monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Alpha-synuclein is a pre-synaptic protein that accumulates in Lewy bodies and Lewy neurites. The literature suggests that the concentration of α-synuclein in the CSF of individuals with Parkinson’s disease is below control levels. In contrast, levels of α-synuclein in the CSF were marginally higher in people with Alzheimer’s disease compared with controls (effect size = 1.183, p = 0.0004). It should be noted that the majority of AD cases in this analysis were diagnosed according to clinical criteria alone, and therefore it is not known to what extent comorbid Lewy body pathology was present. Likewise, it is unclear to what extent comorbid AD pathology may counteract the reported reduction of α-synuclein in the CSF of PD cases.

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