Fetal fibronectin (fFN) antibody and antigen (Recombinant protein)

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-h-fFN-Ag01	Recombinant human fFN Protein	$3090.00
GMP-h-fFN-Ab01	Anti-human fFN mouse monoclonal antibody (mAb)	$1953.00
GMP-h-fFN-Ab02	Anti-human fFN mouse monoclonal antibody (mAb)	$1953.00
GMP-h-fFN-Ab03	Anti-human fFN mouse monoclonal antibody (mAb)	$1953.00
GMP-h-fFN-Ab04	Anti-human fFN mouse monoclonal antibody (mAb)	$1953.00
GMP-h-fFN-Ab05	Anti-human fFN mouse monoclonal antibody (mAb)	$1953.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Pruducts	GMP-h-fFN-Ag01
Product Name	Recombinant human fFN Protein
Target/Biomarker	Fetal fibronectin (fFN)
Alias of Target/Biomarker	CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, SMDCF
Expression platform	mammalian
Isotypes	Recombinant Antigen
Bioactivity validation	Fetal fibronectin (fFN) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in fFN level test of Fertility (premature delivery) and related syndrome evaluation
Products description	Recombinant Human Fetal fibronectin (fFN) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Pruducts	GMP-h-fFN-Ab01,GMP-h-fFN-Ab02,GMP-h-fFN-Ab03,GMP-h-fFN-Ab04,GMP-h-fFN-Ab05
Product Name	Anti-human fFN mouse monoclonal antibody (mAb)
Target/Biomarker	Fetal fibronectin (fFN)
Alias of Target/Biomarker	CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, SMDCF
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Human Fetal fibronectin (fFN) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other Fetal fibronectin (fFN) antibodies in fFN level test of Fertility (premature delivery) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human fFN mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other Fetal fibronectin (fFN) antibodies.
Reconized/Reactive Species	Human
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Figure 1: GeneMedi's GMP-h-fFN-Ab pairs are validated to detect the GMP-h-fFN-Ag01 in ELISA.

   EC50 [Ab01 (capture)-Ab02 (detect)]= 76.68  ppb;

   EC50 [Ab05 (capture)-Ab02 (detect) ]= 130.7  ppb;

   EC50 [Ab03 (capture)-Ab01 (detect) ]= 97.78  ppb;

   EC50 [Ab04 (capture)-Ab01 (detect) ]= 79.94  ppb;

   EC50 [Ab04 (capture)-Ab05 (detect) ]= 530.8  ppb.

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Target/Biomarker information

Fetal fibronectin (fFN) is a protein produced at the boundary between the amniotic sac (which surrounds the baby) and the lining of the mother’s uterus (the decidua). Fetal fibronectin is largely confined to this junction and is thought to help “glue” or maintain the integrity of the boundary between the amniotic sac and the lining of the uterus. A fetal fibronectin test detects fFN in vaginal fluid to help predict the short-term risk of premature delivery. According to the American College of Obstetricians and Gynecologists (ACOG), a normal pregnancy is about 40 weeks, with a woman going into labor between 37 and 42 weeks. A preterm delivery is one that occurs between 20 and 37 weeks of pregnancy. fFN is found in vaginal fluids early in pregnancy because of the normal growth and establishment of tissues at the junction between the amniotic sac and uterus, with levels falling when this phase is complete. fFN is also found in fluids from the vagina after 36 weeks when it is often released into vaginal fluids as the body gets ready for childbirth. However, fFN should not be detectible between 22 and 35 weeks of pregnancy. Elevated levels during this period reflect a disturbance at the junction between the amniotic sac and the lining of the uterus. Elevated fFN in vaginal fluids during these weeks of pregnancy has been associated with an increased risk of preterm labor and delivery. Many pregnant women experience symptoms that suggest preterm labor. These may include uterine contractions, changes in vaginal discharge, backaches, abdominal discomfort, pelvic pressure, cramping, and dilation of the cervix. However, not all symptomatic women will actually have a preterm delivery. The majority will go on to deliver at term. Unfortunately, while premature births can have successful endings, serious complications are possible when a baby leaves the womb early. Premature babies frequently have difficulty breathing and feeding. Their lungs and other organs are immature and do not function normally, and the strain on them can cause persistent health problems. The more premature the newborn, the more likely it is that he or she will experience complications. If a healthcare practitioner thinks that a woman might deliver early, she will consider treatments designed to delay delivery. These treatments can have unwanted side effects, however, so knowing whether or not a woman is likely to deliver prematurely helps in the decision on the best course of action. The fFN test is a relatively noninvasive tool that can help distinguish between those women who are likely to deliver shortly and those who are not.

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