pro B-type natriuretic peptide (proBNP) antibody and antigen (Recombinant protein)

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Diagnostic pro B-type natriuretic peptide (proBNP) antibodies (anti-pro B-type natriuretic peptide, anti-proBNP) and antigens (recombinant pro B-type natriuretic peptide (proBNP) protein) for Cardiovascular disease proBNP detection in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT.

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-h-proBNP-Ag01	Recombinant human proBNP Protein	$3090.00
GMP-h-proBNP-Ab01	Anti-human proBNP mouse monoclonal antibody (mAb)	$1953.00
GMP-h-proBNP-Ab02	Anti-human proBNP mouse monoclonal antibody (mAb)	$1953.00
GMP-h-proBNP-Ab03	Anti-human proBNP human monoclonal antibody (mAb)	$1953.00
GMP-h-proBNP-Ab04	Anti-human proBNP human monoclonal antibody (mAb)	$1953.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No. of Pruducts	GMP-h-proBNP-Ag01
Product Name	Recombinant human proBNP Protein
Target/Biomarker	pro B-type natriuretic peptide (proBNP)
Alias of Target/Biomarker	BNP, Iso-ANP, NPPB
Expression platform	mammalian
Isotypes	Recombinant Antigen
Bioactivity validation	pro B-type natriuretic peptide (proBNP) antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in proBNP level test of Cardiovascular disease (intrinsic cardiac dysfunction) and related syndrome evaluation
Products description	Recombinant Human pro B-type natriuretic peptide (proBNP) protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	positive control, ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA) and Immunonephelometry.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Pruducts	GMP-h-proBNP-Ab01,GMP-h-proBNP-Ab02
Product Name	Anti-human proBNP mouse monoclonal antibody (mAb)
Target/Biomarker	pro B-type natriuretic peptide (proBNP)
Alias of Target/Biomarker	BNP, Iso-ANP, NPPB
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Human pro B-type natriuretic peptide (proBNP) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other pro B-type natriuretic peptide (proBNP) antibodies in proBNP level test of Cardiovascular disease (intrinsic cardiac dysfunction) and related syndrome evaluation.
Tag	mFc
Products description	Anti-human proBNP mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other pro B-type natriuretic peptide (proBNP) antibodies.
Reconized/Reactive Species	Human
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Pruducts	GMP-h-proBNP-Ab03,GMP-h-proBNP-Ab04
Product Name	Anti-human proBNP human monoclonal antibody (mAb)
Target/Biomarker	pro B-type natriuretic peptide (proBNP)
Alias of Target/Biomarker	BNP, Iso-ANP, NPPB
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Human pro B-type natriuretic peptide (proBNP) antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other pro B-type natriuretic peptide (proBNP) antibodies in proBNP level test of Cardiovascular disease (intrinsic cardiac dysfunction) and related syndrome evaluation.
Tag	hFc
Products description	Anti-human proBNP mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Reconized/Reactive Species	Human
Purity	Purity: ≥95% (SDS-PAGE)
Application	ELISA test,Lateral flow immunoassay (LFIA),colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA),turbidimetric inhibition immuno assay (TINIA),immunonephelometry and POCT.
Formulation	Supplied as a 0.2 μM filtered solution of PBS,PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker information

Heart ventricles produce B-type natriuretic peptide (BNP) in response to increased mechanical load and wall stretch. BNP protects the heart from adverse consequences of overload by increasing natriuresis and diuresis, relaxing vascular smooth muscle, inhibiting the renin-angiotensin-aldosterone system, and by counteracting cardiac hypertrophy and fibrosis. BNP is synthesized by human cardiac myocytes as a 108-amino acid prohormone (proBNP), which is cleaved to the 32-residue BNP and the 76-residue N-terminal fragment of proBNP (NT-proBNP). Both can be used as sensitive biomarkers of cardiac dysfunction and well-characterized commercial assays have recently become available. In acute coronary syndromes increased concentrations are strong predictors of recurring myocardial infarction, heart failure, and death. In acute dyspnea, high BNP and NT-proBNP point to a cardiac rather than a pulmonary origin of the symptoms. BNP and NT-proBNP help in the assessment of the severity of ventricular dysfunction and heart failure and as a prognostic predictor, regardless of the primary cause of the condition. They can be used to guide the therapy of heart failure and left ventricular dysfunction. BNP and NT-proBNP work better when they are used for specific clinical purposes, rather than for screening in the general population. Their main strength is the excellent negative predictive value with regard to left ventricular dysfunction and heart failure. BNP and NT-proBNP are nonspecific biomarkers of cardiac dysfunction. Specific diagnostic tools, such as echocardiography, are required to define the actual abnormality.

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