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VDR: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of VDR. The page also collects GeneMedi's different modalities and formats products for VDR in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the VDR target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Introcelluar Protein.

This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018]

Target IDGM-T34234
Target NameVDR
Gene ID7421,22337,24873,706964,486588,100316614,533656,100034072
Gene Symbol and SynonymsNR1I1,PPP1R163,VDR
Uniprot AccessionP11473,P13053,Q28037
Protein Sub-locationIntrocelluar Protein
CategoryTherapeutics Target
Gene EnsemblENSG00000111424
Target ClassificationN/A

Pre-made anti-VDR inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-VDR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-VDR mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody NameSpeciesFormatClassified by tagDetail
Anti-VDR monoclonal antibodyHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquinemabTherapeutics Target antibodyDetail

Recombinant multi-species VDR/ NR1I1/ PPP1R163 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine VDR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products NameSpeciesExpression PlatformDetail
VDR proteinHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquineMammalian cellDetail

Pre-made VDR viral vector in GM Promise-ORFTM

Cat No.Products nameNM IDSpeciesTypeDetail
vGMAP000353Human VDR Adenovirus particleBC060832HumanAdenovirus particleDetail
pGMLV000428human VDR Lentivirus plasmidNM_001017536.1HumanLentivirus plasmidDetail
pGMAP000353Human VDR Adenovirus plasmidBC060832HumanAdenovirus plasmidDetail
vGMLV000428human VDR Lentivirus particleNM_001017536.1HumanLentivirus particleDetail
pGMAD000223mouse Vdr Adenovirus plasmidNM_009504MouseAdenovirus plasmidDetail
pGMLPm001255mouse Vdr Lentivirus plasmidNM_009504MouseLentivirus plasmidDetail
vGMAD000223mouse Vdr Adenovirus particleNM_009504MouseAdenovirus particleDetail
vGMLPm001255mouse Vdr Lentivirus particleNM_009504MouseLentivirus particleDetail

About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.

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