Recombinant multi-species VDR/ NR1I1/ PPP1R163 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine VDR protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The target: VDR, gene name: VDR, also named as NR1I1, PPP1R163. This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018].

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Catalog No.	Product Name	Species	Size	Price
GM-Tg-hg-T34234-Ag-1	Human VDR protein	Human	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-rg-T34234-Ag-1	Rat VDR protein	Rat	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-mg-T34234-Ag-1	Mouse VDR protein	Mouse	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cynog-T34234-Ag-1	Cynomolgus/ Rhesus macaque VDR protein	Cynomolgus/ Rhesus macaque	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-felg-T34234-Ag-1	Feline VDR protein	Feline	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-cang-T34234-Ag-1	Canine VDR protein	Canine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T34234-Ag-1	Bovine VDR protein	Bovine	1mg/10mg/100mg/≥100mg	Inquiry
GM-Tg-bovg-T34234-Ag-1	Equine VDR protein	Equine	1mg/10mg/100mg/≥100mg	Inquiry
Shipping Cost:				760.00

Description

Catalog No.	GM-Tg-hg-T34234-Ag, GM-Tg-rg-T34234-Ag, GM-Tg-mg-T34234-Ag, GM-Tg-cynog-T34234-Ag, GM-Tg-felg-T34234-Ag, GM-Tg-cang-T34234-Ag, GM-Tg-bovg-T34234-Ag, GM-Tg-equg-T34234-Ag-1
Products Name	VDR protein
Species	Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name	VDR
Protein Sub-location	Introcelluar Protein
Isotypes	Recombinant protein
Expression platform	Mammalian cell
Bioactivity validation	Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag	His
Products description	Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine VDR protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity	Purity: ≥95% (SDS-PAGE)
Application	In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Supplied as a 0.2 μM filtered solution of PBS, PH7.4.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.