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IDH1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of IDH1. The page also collects GeneMedi's different modalities and formats products for IDH1 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the IDH1 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Introcelluar Protein.

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

Target IDGM-T69563
Target NameIDH1
Gene ID3417,15926,24479,710019,478889,751618,281235,100066416
Gene Symbol and SynonymsE030024J03Rik,HEL-216,HEL-S-26,Id-1,IDCD,IDH,Idh-1,IDH1,IDP,IDPC,PICD
Uniprot AccessionO75874,P41562,Q9XSG3
Protein Sub-locationIntrocelluar Protein
CategoryTherapeutics Target, Immuno-oncology Target
DiseaseOvary Cancer
Gene EnsemblENSG00000138413
Target ClassificationCheckpoint-Immuno Oncology

Pre-made anti-IDH1 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-IDH1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-IDH1 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody NameSpeciesFormatClassified by tagDetail
Anti-IDH1 monoclonal antibodyHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquinemabTherapeutics Target antibodyDetail

Recombinant multi-species IDHC/ IDH1/ HEL-216 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IDH1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products NameSpeciesExpression PlatformDetail
IDH1 proteinHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquineMammalian cellDetail

Pre-made IDH1 viral vector in GM Promise-ORFTM

Cat No.Products nameNM IDSpeciesTypeDetail
vGMLV000343human IDH1 Lentivirus particleNM_001282386.1HumanLentivirus particleDetail
pGMAD000601human IDH1 Adenovirus plasmidNM_005896.3HumanAdenovirus plasmidDetail
pGMLV000345human IDH1 Lentivirus plasmidNM_001282386.1HumanLentivirus plasmidDetail
pGMLV000644human IDH1 Lentivirus plasmidNM_005896.3HumanLentivirus plasmidDetail
pGMLV000344human IDH1 Lentivirus plasmidNM_001282386.1HumanLentivirus plasmidDetail
vGMLV000644human IDH1 Lentivirus particleNM_005896.3HumanLentivirus particleDetail
vGMLV000345human IDH1 Lentivirus particleNM_001282386.1HumanLentivirus particleDetail
pGMLV000343human IDH1 Lentivirus plasmidNM_001282386.1HumanLentivirus plasmidDetail
vGMLV000344human IDH1 Lentivirus particleNM_001282386.1HumanLentivirus particleDetail
vGMAD000601human IDH1 Adenovirus particleNM_005896.3HumanAdenovirus particleDetail
pGMLPm001512mouse Idh1 Lentivirus plasmidNM_010497MouseLentivirus plasmidDetail
vGMLPm001512mouse Idh1 Lentivirus particleNM_010497MouseLentivirus particleDetail

About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.

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