Human IDH1/HEL-216/ HEL-S-26 ORF/cDNA clone-Lentivirus plasmid (NM_001282386.1)
Pre-made Human IDH1/HEL-216/ HEL-S-26 Lentiviral expression plasmid for IDH1 lentivirus packaging, IDH1 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.
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Product information
Catalog No. | Product Name | Plasmid Grade | Plasmid quantity |
---|---|---|---|
pGMLV000343 | Human IDH1 Lentivirus plasmid | Research Grade | 10mg, 50mg, 100mg, 500mg, >1g |
GMP-like Grade | 10mg, 50mg, 100mg, 500mg, >1g | ||
High Quality (HQ) Grade | |||
Seed | 5ug |
Product Description
Catalog ID | pGMLV000343 |
Gene Name | IDH1 |
Accession Number | NM_001282386.1 |
Gene ID | 3417 |
Species | Human |
Product Type | Lentivirus plasmid (overexpression) |
Insert Length | 1245 bp |
Gene Alias | HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD |
Fluorescent Reporter | ZsGreen |
Mammalian Cell Selection | Puromyocinmyocin |
Fusion Tag | 3xflag+6xhis(C-Terminal) |
Promoter | CMV |
Resistance | Amplicin |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
---|---|---|
Target Antibody | GM-Tg-g-T69563-Ab | Anti-IDH1 monoclonal antibody |
Target Antigen | GM-Tg-g-T69563-Ag | IDH1 protein |
ORF Viral Vector | pGMLV000343 | Human IDH1 Lentivirus plasmid |
ORF Viral Vector | pGMLV000344 | Human IDH1 Lentivirus plasmid |
ORF Viral Vector | pGMLV000345 | Human IDH1 Lentivirus plasmid |
ORF Viral Vector | pGMLV000644 | Human IDH1 Lentivirus plasmid |
ORF Viral Vector | pGMLV001085 | Human IDH1 Lentivirus plasmid |
ORF Viral Vector | pGMLV001957 | Human IDH1 Lentivirus plasmid |
ORF Viral Vector | pGMAD000601 | Human IDH1 Adenovirus plasmid |
ORF Viral Vector | pGMPC000259 | Human IDH1 Mammalian (Non-Viral Vector) plasmid |
ORF Viral Vector | pGMPC000260 | Human IDH1 Mammalian (Non-Viral Vector) plasmid |
ORF Viral Vector | vGMLV000343 | Human IDH1 Lentivirus particle |
ORF Viral Vector | vGMLV000344 | Human IDH1 Lentivirus particle |
ORF Viral Vector | vGMLV000345 | Human IDH1 Lentivirus particle |
ORF Viral Vector | vGMLV000644 | Human IDH1 Lentivirus particle |
ORF Viral Vector | vGMLV001085 | Human IDH1 Lentivirus particle |
ORF Viral Vector | vGMLV001957 | Human IDH1 Lentivirus particle |
ORF Viral Vector | vGMAD000601 | Human IDH1 Adenovirus particle |
ORF Viral Vector | pGMLV002527 | Human IDH1 Lentivirus plasmid |
Target information
Target ID | GM-T69563 |
Target Name | IDH1 |
Gene ID | 3417, 15926, 710019, 24479, 751618, 478889, 281235, 100066416 |
Gene Symbol and Synonyms | E030024J03Rik,HEL-216,HEL-S-26,Id-1,IDCD,IDH,Idh-1,IDH1,IDP,IDPC,PICD |
Uniprot Accession | O75874 |
Uniprot Entry Name | IDHC_HUMAN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target, Immuno-oncology Target |
Disease | Ovary Cancer |
Gene Ensembl | ENSG00000138413 |
Target Classification | Checkpoint-Immuno Oncology |
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
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