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AAV2 variant (Y272F, Y444F, Y500F, Y730F) vector system (retina-validated AAV expression and packaging plasmids)
AAV protocol Download AAV User Manual Download Capsid mutant-AAV serotype 2 variant(AAV2-(Y272F,Y444F,Y500F,Y730F)) system-Introduction
GeneMedi's AAV2 variant (Y272F, Y444F, Y500F, Y730F) Vector System (AAV serotype 2 variant(Y272F,Y444F,Y500F,Y730F) helper-free packaging plasmids system) is including AAV2 variant (Y272F,Y444F,Y500F,Y730F) Rep-Cap plamid (AAV2 variant (Y272F, Y444F, Y500F, Y730F) -RC plasmid), AAV helper plasmid and AAV expression vectors (overexpression or shRNA).
You can choose your suiltable AAV expression vector plasmids from GeneMedi's AAV expression vector core. The AAV expression vector plasmids were constructed with differernt expression cassettes,containing kinds of verified protomters and reporters including GFP, zsgreen, RFP, mcherry and luciferase. The GeneMedi's AAV expression vectors have been proved very suitalble for unique gene overexpression or shRNA-mediated knock-down (also called RNAi (RNA interference ). You can also achieve gene knock-out(KO) or gene editing using our Crispr-cas9-gRNA AAV expression vector.
AAV2 variant (Y272F, Y444F, Y500F, Y730F) Rep-Cap plamid supplies the AAV2 Rep(replication) proteins and the AAV2 variant (Y272F, Y444F, Y500F, Y730F) capsid-engineered protein.
The tissue tropism of AAV2 variant (Y272F, Y444F, Y500F, Y730F) vector has been validated in retina (retinal ganglion cells) by both intravitreal injection and sub-retinal injection with potential applications in retina gene therapy.
| Product Name | Organization Type | Price(In USD) | Qty (Quantity) | Sum(In USD) |
|---|---|---|---|---|
| AAV2 variant (Y272F,Y444F,Y500F,Y730F) vector systemCat.No.:P-PK041. AAV2 variant (Y272F, Y444F, Y500F, Y730F) Rep-Cap plasmid, 5ug2. AAV Helper Plasmid, 5ug3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug | Academic | 3024 | ||
| AAV2 variant (Y272F,Y444F,Y500F,Y730F) vector systemCat.No.:P-PK041. AAV2 variant (Y272F, Y444F, Y500F, Y730F) Rep-Cap plasmid, 5ug2. AAV Helper Plasmid, 5ug3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug | Industry R&D (excluding CRO&CDMO&CXO) | Inquiry | ||
| AAV2 variant (Y272F,Y444F,Y500F,Y730F) vector systemCat.No.:P-PK041. AAV2 variant (Y272F, Y444F, Y500F, Y730F) Rep-Cap plasmid, 5ug2. AAV Helper Plasmid, 5ug3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug Expression vector refers only to B01, if you need other expression vector, please click →AAV Expression Vector list | CRO&CDMO& CXO&CMC& Manufacturing company | Inquiry | ||
| If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service. | ||||
| Shipping Cost: | 169.00 | |||
| Total: | ||||
AAV2 capsid variant (Y272F,Y444F,Y500F,Y730F) tissue tropism and gene transduction
(serotype-specific AAV infection)
The tissue tropism of AAV2 variant (Y272F, Y444F, Y500F, Y730F) vector has been validated in retina (retinal ganglion cells) by both intravitreal injection and sub-retinal injection with potential applications in retina gene therapy.
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Virus and titer: AAV2 variant (Y272F, Y444F, Y500F, Y730F) vector system, 1×1012 vg/ml Animal: mouse, C57, 2 months Infection site: retina Gene delivery method: subretinal cavity injection, 3μl Determine assay: 3 weeks post infection, wholemount, immunofluorescence microscopy
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