AAV4 Vector System (AAV4 expression system, AAV4 packaging plasmid system)

GeneMedi's AAV4 Vector System (AAV serotype 4 helper-free packaging plasmids system) is including AAV4 Rep-Cap plamid (AAV4-RC plasmid, or called AAV-RC1 plasmid), AAV helper plasmid and AAV expression vectors (overexpression or shRNA).

GeneMedi's AAV expression vectors have been inserted with differernt expression cassettes, containing kinds of verified protomters and reporters including GFP, zsgreen, RFP, mcherry and luciferase. The GeneMedi's AAV expression vectors have been proved very suitalble for unique gene overexpression or shRNA-mediated knock-down (also called RNAi (RNA interference ). You can also achieve gene knock-out(KO) or gene editing using our Crispr-cas9-gRNA AAV expression vector.

AAV4 Rep-Cap plamid supplies the AAV2 Rep(replication) proteins and the AAV4 capsid protein.

The tissue tropism of AAV4 vector has been validated in lung and heart, as well as low transduction efficiency and viral genome copy numbers in the liver, with potential applications in tissue-specific gene therapy.