AAV-AAV4 vector system (AAV-AAV4 expression system, AAV-AAV4 packaging plasmid system)

GeneMedi (GM) AAV4 Vector system is including: 1) AAV4 Rep-Cap plasmid (AAV4-RC plasmid) 2) AAV Helper plasmid 3) AAV expression vectors (overexpression or shRNA).

You can produce AAV4 particle in 293T cell line in high titer using GeneMedi's AAV4 Rep-Cap plasmid with GM's AAV expression vector (overexpression or shRNA) and AAV helper plasmid.

The tissue tropism of AAV4 vector has been validated in lung and heart, as well as low transduction efficiency and viral genome copy numbers in the liver, with potential applications in tissue-specific gene therapy.

Target products collectionGo to AAV vector system >>



Product Description

Cat.NO Product Name Organization Type Price(In USD)
P-PK27 AAV-VEC Vector System
1. AAV4 Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
Academic 3379
P-PK27 AAV-VEC Vector System
1. AAV4 Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
Industry R&D
(excluding
CRO&CDMO&CXO)
P-PK27 AAV-VEC Vector System
1. AAV4 Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
CRO&CDMO&
CXO&CMC&
Manufacturing company
P-PK27-Kan AAV-VEC Vector System(Kan resistance)
1. AAV4 Rep-Cap Plasmid(Kan resistance), 10mg
2. AAV Helper Plasmid(Kan resistance), 10mg
3. pGMAAV-CMV-MCS-T2A-ZsGreen (Kan resistance) (P-AAVV-B01-Kan), 10mg
All
Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Vector System and do not provide seed stocks.
P-RC27 AAV-VEC Rep-Cap Plasmid
Academic 2062
P-RC27 AAV-VEC Rep-Cap Plasmid
Industry R&D
(excluding
CRO&CDMO&CXO)
P-RC27 AAV-VEC Rep-Cap Plasmid
CRO&CDMO&
CXO&CMC&
Manufacturing company
P-RC27-Kan AAV-VEC Rep-Cap Plasmid(Kan resistance)
All
Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Rep-Cap Plasmids and do not provide seed stocks.
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.
Terms of sale:
For Seed (5ug):
The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for any other party.

For plasmid production&lification (≥10mg):
The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for themselves or any other party.

Citation

Title Publication Date
HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation Cell Discovery 2023/8/15
Chimeric antigen receptor-modified macrophages ameliorate liver fibrosis in preclinical models Journal of Hepatology 2024/2/8
Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax Kidney International 2022/9/8
CD8 T Cell-Derived Exosomal miR-186-5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis Advanced Science 2023/7/3
Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence Nature Communications 2024/2/16
Intestinal dysbiosis exacerbates susceptibility to the anti-NMDA receptor encephalitis-like phenotype by changing blood brain barrier permeability and immune homeostasis Brain, Behavior, and Immunity 2023/11/27
SIRT6 protects vascular smooth muscle cell from osteogenic transdifferentiation via Runx2 in chronic kidney disease Journal of Clinical Investigation 2021/11/18
Therapeutic reversal of Huntington's disease by in vivo self-assembled siRNAs BRAIN 2021/12/15
NLRC3 Expression in Macrophage Impairs Glycolysis and Host Immune Defence by Modulating the NF-κB-NFAT5 Complex During Sepsis-induced Immunosuppression Molecular Therapy 2022/9/6
Hepatic HuR modulates lipid homeostasis in response to high-fat diet Nature Communications 2020/6/16


Validation data

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Associated products and services


Products & Service Products & Service Information
AAV Packaging service Detail
Promise-ORF™ viral CDNA library Detail
Plasmid DNA Rapid Preparation Service Detail