AAV5 vector system (AAV5 expression system, AAV5 packaging plasmid system)

GeneMedi's AAV5 Vector System (AAV serotype 5 helper-free packaging plasmids system) is including AAV5 Rep-Cap plamid (AAV5-RC plasmid, or called AAV-RC5 plasmid), AAV helper plasmid and AAV expression vectors (overexpression or shRNA).

GeneMedi's AAV expression vectors have been inserted with differernt expression cassettes,containing kinds of verified protomters and reporters including GFP, zsgreen, RFP, mcherry and luciferase. The GeneMedi's AAV expression vectors have been proved very suitalble for unique gene overexpression or shRNA-mediated knock-down (also called RNAi (RNA interference). You can also achieve gene knock-out(KO) or gene editing using our Crispr-cas9-gRNA AAV expression vector.

AAV5 Rep-Cap plamid supplies the AAV2 Rep(replication) proteins and the AAV5 capsid protein.

The tissue tropism of AAV5 vector has been validated in neuron (CNS), retina, lung and pancreas, with potential applications in tissue-specific gene therapy.