AAV6 vector system (AAV6 expression system, AAV6 packaging plasmid system, T cell validated )

GeneMedi (GM) AAV6 Vector system is including: 1) AAV6 Rep-Cap plasmid (AAV6-RC plasmid) 2) AAV Helper plasmid 3) AAV expression vectors (overexpression or shRNA).

You can produce AAV6 particle in 293T cell line in high titer using GeneMedi's AAV6 Rep-Cap plasmid with GM's AAV expression vector (overexpression or shRNA) and AAV helper plasmid.

The tissue tropism of AAV6 vector has been validated in neuron(CNS),lung,liver,heart and muscle,with potential applications in tissue-specific gene therapy.AAV6 has also been proved a high transduction efficency in T cell,wtih potential applications in T cell-mediated cancer immunotherapies, including Chimaeric antigen receptor T(CAR-T) and TCR engineered T(TCR-T) cell therapy.

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Product Description

Cat.NO Product Name Organization Type Price(In USD)
P-PK08 AAV6 Vector System
1. AAV6 Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
Academic 2028
P-PK08 AAV6 Vector System
1. AAV6 Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
Industry R&D
(excluding
CRO&CDMO&CXO)
P-PK08 AAV6 Vector System
1. AAV6 Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
CRO&CDMO&
CXO&CMC&
Manufacturing company
P-PK08-Kan AAV6 Vector System(Kan resistance)
1. AAV6 Rep-Cap Plasmid(Kan resistance), 10mg
2. AAV Helper Plasmid(Kan resistance), 10mg
3. pGMAAV-CMV-MCS-T2A-ZsGreen (Kan resistance) (P-AAVV-B01-Kan), 10mg
All
Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Vector System and do not provide seed stocks.
P-RC08 AAV6 Rep-Cap Plasmid
Academic 935
P-RC08 AAV6 Rep-Cap Plasmid
Industry R&D
(excluding
CRO&CDMO&CXO)
P-RC08 AAV6 Rep-Cap Plasmid
CRO&CDMO&
CXO&CMC&
Manufacturing company
P-RC08-Kan AAV6 Rep-Cap Plasmid(Kan resistance)
All
Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Rep-Cap Plasmids and do not provide seed stocks.
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.
Terms of sale:
For Seed (5ug):
The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for any other party.

For plasmid production&lification (≥10mg):
The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for themselves or any other party.

Citation

Title Publication Date
LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis CELL 2019/8/29
Lineage-specific regulatory changes in hypertrophic cardiomyopathy unraveled by single-nucleus RNA-seq and spatial transcriptomics Cell Discovery 2023/1/17
FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System Circulation 2024/2/16
Satellite‐based On‐orbit Printing of 3d Tumor Models Advanced Materials 2023/12/25
CD1d protects against hepatocyte apoptosis in non?alcoholic steatohepatitis Journal of Hepatology 2023/10/28
Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal Cell Stem Cell 2022/9/1
TRIB3 Interacts With β-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis Gastroenterology 2019/12/28
Manipulating bioactivities of endothelial progenitor cell-derived exosomes for promoting angiogenesis in ischemic vascular diseases Nano Today 2023/1/13
Significance of m6A regulation in environmental health and safety (EHS) assessment: MWCNTs induced pulmonary toxicity through m6A modifications of mitophagy-related genes Nano Today 2022/9/21
Cold-activated brown fat-derived extracellular vesicle-miR-378a-3p stimulates hepatic gluconeogenesis in male mice Nature Communications 2023/9/6


Validation data

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Figure. Selected transduction results of AAV in vitro (in 293T cell line)

Virus and titer: AAV1/AAV6/AAV8/AAV-Rh10/AAV-DJ/AAV9-GFP, 1×1012 vg/ml
Cells: HEK-293T
MOI: MOI=1×104
Determine assay: 36 hours post infection, immunofluorescence microscopy


Associated products and services


Products & Service Products & Service Information
AAV Packaging service Detail
Promise-ORF™ viral CDNA library Detail
Plasmid DNA Rapid Preparation Service Detail