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AAV serotype 6 (AAV capsid 6) system - Introduction

GeneMedi's AAV6 Rep-Cap plasmid (serotype 6-specific AAV RC plasmid), also named AAV6-RC plasmid, or AAV-RC6 plasmid, is part of AAV6 packaging system. AAV6 Rep-Cap plamid supplies the AAV6 Rep (replication) proteins and the AAV6 capsid protein.

You can produce AAV6 paticle in 293T cell line in high titer using GeneMedi's AAV6 Rep-Cap plasmid with GeneMedi's AAV expression vector (overexpression or shRNA) and AAV helper plasmid.

The tissue tropism of AAV6 vector has been validated in neuron (CNS), lung, liver, heart and muscle, with potential applications in tissue-specific gene therapy.

AAV6 has also been proved a high transduction efficency in T cell, wtih potential applications in T cell-mediated cancer immunotherapies, including Chimaeric antigen receptor T(CAR-T) and TCR engineered T (TCR-T) cell therapy.

Product Name Contents Price(In USD) Qty (Quantity) Sum(In USD)
AAV6 Rep-Cap Plasmid Serotype: AAV6
Size: 5ug
590
Shipping Cost: 130.00
Total:

AAV6 vector tissue tropism and gene transduction (serotype-specific AAV infection)

The tissue tropism of AAV6 vector has been validated in neuron (CNS), lung, liver, heart and muscle, with potential applications in tissue-specific gene therapy.

AAV6 has also been proved a high transduction efficency in T cell, wtih potential applications in T cell-mediated cancer immunotherapies, including Chimaeric antigen receptor T(CAR-T) and TCR engineered T (TCR-T) cell therapy.

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Figure. Selected transduction results of AAV in vitro (in 293T cell line)

Virus and titer: AAV1/AAV6/AAV8/AAV-Rh10/AAV-DJ/AAV9-GFP, 1×1012 vg/ml
Cells: HEK-293T
MOI: MOI=1×104
Determine assay: 36 hours post infection, immunofluorescence microscopy


Other AAV Rep-Cap Plasmid


AAV1 Rep-Cap Plasmid

AAV2 Rep-Cap Plasmid

AAV2 variant (Y444F) Rep-Cap plasmid

AAV2 variant (Y272F, Y444F, Y500F, Y730F) Rep-Cap plasmid

AAV2 variant (Y444F, Y730F, Y500F, Y272F, Y704F, Y252F) Rep-Cap plasmid

AAV2 variant(AAV2.7m8) Rep-Cap plasmid

AAV5 Rep-Cap Plasmid

AAV8 Rep-Cap Plasmid

AAV8-1m Rep-Cap plasmid

AAV8-2m Rep-Cap plasmid



AAV8 variant (Y733F, Y447F, Y275) Rep-Cap plasmid

AAV9 Rep-Cap Plasmid

AAV-Rh.10 Rep-Cap Plasmid

AAV-DJ Rep-Cap Plasmid

AAV-DJ/8 Rep-Cap Plasmid

AAV-Retro (Retrograde) Rep-Cap plasmid

AAV9-PHP.B Rep-Cap plasmid

AAV9-PHP.eB Rep-Cap plasmid

AAV9-PHP.S Rep-Cap plasmid