AAV-BR1 vector system (AAV-BR1 expression system, AAV-BR1 packaging plasmid system)

GeneMedi's AAV-BR1 Vector System (AAV serotype BR1 helper-free packaging plasmids system) is including AAV-BR1 Rep-Cap plamid (AAV-BR1-RC plasmid, or called AAV-RC1 plasmid), AAV helper plasmid and AAV expression vectors (overexpression or shRNA).

GeneMedi's AAV expression vectors have been inserted with differernt expression cassettes, containing kinds of verified protomters and reporters including GFP, zsgreen, RFP, mcherry and luciferase. The GeneMedi's AAV expression vectors have been proved very suitalble for unique gene overexpression or shRNA-mediated knock-down (also called RNAi (RNA interference ). You can also achieve gene knock-out(KO) or gene editing using our Crispr-cas9-gRNA AAV expression vector.

AAV-BR1 Rep-Cap plamid supplies the AAV2 Rep(replication) proteins and the AAV-BR1 capsid protein.

The tissue tropism of AAV-BR1 vector has been validated in endothelium, with potential applications in tissue-specific gene therapy.