AAV-PHP.B vector system (AAV-PHP.B expression and packaging plasmid system, across the blood-brain barrier(BBB) ) (Amp and Kanamycin) (GeneMedi Owned)

GeneMedi (GM) AAV-PHP.B Vector system is including: 1) AAV-PHP.B Rep-Cap plasmid (AAV-PHP.B-RC plasmid) 2) AAV Helper plasmid 3) AAV expression vectors (overexpression or shRNA).

You can produce AAV-PHP.B particle in 293T cell line in high titer using GeneMedi's AAV-PHP.B Rep-Cap plasmid with GM's AAV expression vector (overexpression or shRNA) and AAV helper plasmid.

With the blood-brain barrier(BBB) crossing propertiy, AAV-PHP.B shows potential applications in CNS (neuron) gene therapy, especially in neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), or neurogenetic disease such as Spinal Muscular Atrophy (SMA) and Huntington's disease(HD).

GeneMedi offers both Ampicillin (Amp) resistance and Kanamycin (Kan) resistance for the AAV Rep-Cap Plasmids, AAV expression Plasmids and AAV helper Plasmid.

Target products collectionGo to AAV vector system >>

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Product Description

Cat.NO Product Name Organization Type Price(In USD) First Order Discount First Order Discount Price
P-PK18 AAV-PHP.B Vector System (Amp resistance)
1. AAV-PHP.B Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
Academic 2664 50% 1332
P-PK18 AAV-PHP.B Vector System (Amp resistance)
1. AAV-PHP.B Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
Biotech & Pharma & Medical Device & Diagnostics 50%
P-PK18 AAV-PHP.B Vector System (Amp resistance)
1. AAV-PHP.B Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
CRO&CDMO&
CXO&CMC&
Manufacturing company 		50%
P-PK18 AAV-PHP.B Vector System (Amp resistance)
1. AAV-PHP.B Rep-Cap Plasmid, ≥10mg
2. AAV Helper Plasmid, ≥10mg
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01-Kan), ≥10mg
 All
P-PK18-Kan AAV-PHP.B Vector System (Kan resistance)
1. AAV-PHP.B Rep-Cap Plasmid (Kan resistance) , ≥10mg
2. AAV Helper Plasmid (Kan resistance) , ≥10mg
3. pGMAAV-CMV-MCS-T2A-ZsGreen (Kan resistance) (P-AAVV-B01-Kan), ≥10mg
 All
P-RC18 AAV-PHP.B Rep-Cap Plasmid (Amp resistance)
Size：5ug 		Academic 1308 50% 654
P-RC18 AAV-PHP.B Rep-Cap Plasmid (Amp resistance)
Size：5ug 		Biotech & Pharma & Medical Device & Diagnostics 50%
P-RC18 AAV-PHP.B Rep-Cap Plasmid (Amp resistance)
Size：5ug 		CRO&CDMO&
CXO&CMC&
Manufacturing company		 50%
P-RC18 AAV-PHP.B Rep-Cap Plasmid (Amp resistance)
Size：≥10mg 		All
P-RC18-Kan AAV-PHP.B Rep-Cap Plasmid(Kan resistance)
Size：≥10mg 		All
GeneMedi offers both seed and amplification services for the Amp-resistant AAV Vector System.
GeneMedi only offers amplification services and do not provide seed for the Kan-resistant AAV Vector System currently.
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.
Terms of sale:
For Seed (5ug):
The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for any other party.

For plasmid production& amplification (≥10mg):
The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for themselves or any other party.

Citation

Title Publication Date
Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure Harbin Medical University 2023/3/27
Long non-coding RNA NORAD/miR-224-3p/MTDH axis contributes to CDDP resistance of esophageal squamous cell carcinoma by promoting nuclear accumulation of β-catenin Molecular Cancer 2021/12/10
Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice Nature Metabolism 2023/9/21
GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis Nature Communications 2023/2/18
Single-Nucleus RNA Sequencing Reveals that Decorin Expression in the Amygdala Regulates Perineuronal Nets Expression and Fear Conditioning Response after Traumatic Brain Injury Advanced Science 2022/1/17
CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc Mol Cancer 2020/10/26
YAP regulates the liver size during the fasting-refeeding transition in mice Acta Pharmaceutica Sinica B 2022/12/21
Targeting FABP4 in elderly mice rejuvenates liver metabolism and ameliorates aging-associated metabolic disorders Metabolism: clinical and experimental 2023/2/25
Local GABAergic signaling within sensory ganglia controls peripheral nociceptive transmission Journal of Clinical Investigation 2017/4/4
Set7/9 aggravates ischemic brain injury via enhancing glutamine metabolism in a blocking Sirt5 manner Cell Death & Differentiation 2024/2/16


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Products & Service Products & Service Information
AAV Packaging service Detail
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Plasmid DNA Rapid Preparation Service Detail