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AAV-PHP.B Rep-Cap plasmid (specific serotype across (blood-brain barrier(BBB) AAV RC plamid)
GeneMedi's AAV-PHP.B Rep-Cap plasmid supplies the AAV2 Rep (replication) proteins and the AAV-PHP.B capsid protein.
You can produce AAV-PHP.B particle in 293T cell line in high titer using GeneMedi's AAV-PHP.B Rep-Cap plasmid with GM's AAV expression vector (overexpression or shRNA) and AAV helper plasmid.
With the blood-brain barrier(BBB) crossing propertiy, AAV-PHP.B shows potential applications in CNS (neuron) gene therapy, especially in neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), or neurogenetic disease such as Spinal Muscular Atrophy (SMA) and Huntington's disease(HD).
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vector system
>>Product Description
| Cat.NO | Product Name | Organization Type | Price(In USD) | ||
|---|---|---|---|---|---|
| P-RC18 | AAV-PHP.B Rep-Cap Plasmid | Academic | 1308 | ||
| P-RC18 | AAV-PHP.B Rep-Cap Plasmid | Industry R&D (excluding CRO&CDMO&CXO) |
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| P-RC18 | AAV-PHP.B Rep-Cap Plasmid |
CRO&CDMO& CXO&CMC& Manufacturing company |
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| P-RC18-Kan | AAV-PHP.B Rep-Cap Plasmid(Kan resistance) |
All | |||
| Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Rep-Cap Plasmids and do not provide seed stocks. | |||||
| P-PK18 | AAV-PHP.B Vector
System
1. AAV-PHP.B Rep-Cap Plasmid, 5ug 2. AAV Helper Plasmid, 5ug 3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug |
Academic | 2664 | ||
| P-PK18 | AAV-PHP.B Vector
System
1. AAV-PHP.B Rep-Cap Plasmid, 5ug 2. AAV Helper Plasmid, 5ug 3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug | Industry R&D (excluding CRO&CDMO&CXO) |
|||
| P-PK18 | AAV-PHP.B Vector
System
1. AAV-PHP.B Rep-Cap Plasmid, 5ug 2. AAV Helper Plasmid, 5ug 3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug | CRO&CDMO& CXO&CMC& Manufacturing company |
|||
| P-PK18-Kan | AAV-PHP.B Vector
System(Kan resistance)
1. AAV-PHP.B Rep-Cap Plasmid(Kan resistance), 10mg 2. AAV Helper Plasmid(Kan resistance), 10mg 3. pGMAAV-CMV-MCS-T2A-ZsGreen (Kan resistance) (P-AAVV-B01-Kan), 10mg |
All | |||
| Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Vector System and do not provide seed stocks. | |||||
| If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service. | |||||
|
Terms of sale: For Seed (5ug): The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for any other party. For plasmid production&lification (≥10mg): The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for themselves or any other party. |
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Citation
| Title | Publication | Date |
|---|---|---|
| Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure | Harbin Medical University | 2023/3/27 |
| Long non-coding RNA NORAD/miR-224-3p/MTDH axis contributes to CDDP resistance of esophageal squamous cell carcinoma by promoting nuclear accumulation of β-catenin | Molecular Cancer | 2021/12/10 |
| Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice | Nature Metabolism | 2023/9/21 |
| GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis | Nature Communications | 2023/2/18 |
| Single-Nucleus RNA Sequencing Reveals that Decorin Expression in the Amygdala Regulates Perineuronal Nets Expression and Fear Conditioning Response after Traumatic Brain Injury | Advanced Science | 2022/1/17 |
| CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc | Mol Cancer | 2020/10/26 |
| YAP regulates the liver size during the fasting-refeeding transition in mice | Acta Pharmaceutica Sinica B | 2022/12/21 |
| Targeting FABP4 in elderly mice rejuvenates liver metabolism and ameliorates aging-associated metabolic disorders | Metabolism: clinical and experimental | 2023/2/25 |
| Local GABAergic signaling within sensory ganglia controls peripheral nociceptive transmission | Journal of Clinical Investigation | 2017/4/4 |
| Set7/9 aggravates ischemic brain injury via enhancing glutamine metabolism in a blocking Sirt5 manner | Cell Death & Differentiation | 2024/2/16 |
Validation data
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Associated products and services
| Products & Service | Products & Service Information |
|---|---|
| AAV Packaging service | Detail |
| Promise-ORF™ viral CDNA library | Detail |
| Plasmid DNA Rapid Preparation Service | Detail |
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