AAV-PHP.eB Rep-Cap plasmid (specific serotype across (blood-brain barrier(BBB) AAV RC plamid)

GeneMedi's AAV-PHP.eB Rep-Cap plasmid supplies the AAV2 Rep (replication) proteins and the AAV-PHP.eB capsid protein.

You can produce AAV-PHP.eB particle in 293T cell line in high titer using GeneMedi's AAV-PHP.eB Rep-Cap plasmid with GM's AAV expression vector (overexpression or shRNA) and AAV helper plasmid.

With the blood-brain barrier(BBB) crossing propertiy, AAV-PHP.B shows potential applications in CNS (neuron) gene therapy, especially in neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), or neurogenetic disease such as Spinal Muscular Atrophy (SMA) and Huntington's disease(HD).

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Product Description

Cat.NO Product Name Organization Type Price(In USD)
P-RC20 AAV-PHP.eB Rep-Cap Plasmid
Academic 1719
P-RC20 AAV-PHP.eB Rep-Cap Plasmid
Industry R&D
(excluding
CRO&CDMO&CXO)
P-RC20 AAV-PHP.eB Rep-Cap Plasmid
CRO&CDMO&
CXO&CMC&
Manufacturing company
P-RC20-Kan AAV-PHP.eB Rep-Cap Plasmid(Kan resistance)
All
Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Rep-Cap Plasmids and do not provide seed stocks.
P-PK20 AAV-PHP.eB Vector System
1. AAV-PHP.eB Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
Academic 3024
P-PK20 AAV-PHP.eB Vector System
1. AAV-PHP.eB Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
Industry R&D
(excluding
CRO&CDMO&CXO)
P-PK20 AAV-PHP.eB Vector System
1. AAV-PHP.eB Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
CRO&CDMO&
CXO&CMC&
Manufacturing company
P-PK20-Kan AAV-PHP.eB Vector System(Kan resistance)
1. AAV-PHP.eB Rep-Cap Plasmid(Kan resistance), 10mg
2. AAV Helper Plasmid(Kan resistance), 10mg
3. pGMAAV-CMV-MCS-T2A-ZsGreen (Kan resistance) (P-AAVV-B01-Kan), 10mg
All
Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Vector System and do not provide seed stocks.
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.
Terms of sale:
For Seed (5ug):
The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for any other party.

For plasmid production&lification (≥10mg):
The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for themselves or any other party.

Citation

Title Publication Date
Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L Signal Transduction and Targeted Therapy 2023/10/11
The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer Molecular Cancer 2020/3/12
Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice Nature Metabolism 2022/11/18
Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis Nature Communications 2022/12/19
Ciliary Type III Adenylyl Cyclase in the VMH Is Crucial for High-Fat Diet-Induced Obesity Mediated by Autophagy Advanced science 2021/11/16
The E3 ubiquitin ligase HUWE1 acts through the N-Myc-DLL1-NOTCH1 signaling axis to suppress glioblastoma progression Cancer communications 2022/7/18
Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects Acta Pharmaceutica Sinica B 2022/12/14
Microneedle-mediated gene delivery for the treatment of ischemic myocardial disease Sci Adv 2020/6/29
Palmitoylation of PKCδ by ZDHHC5 in hypothalamic microglia presents as a therapeutic target for fatty liver disease Theranostics 2024/1/1


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Associated products and services


Products & Service Products & Service Information
AAV Packaging service Detail
Promise-ORF™ viral CDNA library Detail
Plasmid DNA Rapid Preparation Service Detail