AAV9-PHP.eB Rep-Cap plasmid (AAV serotype PHP.eB validated in neuron and muscle)
Capsid engineered-AAV serotype 9 variant (AAV9-PHP.eB) system - Introduction
GeneMedi's AAV-PHP.eB Rep-Cap plasmid (specific serotype across (blood-brain barrier(BBB) AAV RC plamid),
also named AAV-PHP.eB RC plasmid,is part of AAV-PHP.eB packaging system. AAV-PHP.eB Rep-Cap plamid supplies
the AAV2 Rep(replication) proteins and the AAV-PHP.eB capsid protein.
You can produce AAV-PHP.eB
paticle in 293T cell line in high titer using GeneMedi's AAV-PHP.eB Rep-Cap plasmid with GeneMedi's AAV
expression vector(overexpression or shRNA) and AAV helper plasmid.
AAV-PHP.eB (also called
AAV9-PHP.eB) is a variant from AAV9 with AAV capsid evolution (AAV capsid peptide display). With enhanced
CNS tropism (neurotropic),the AAV-PHP.eB variant vector has also been validated in gene delivery in vivo
across the blood-brain barrier(BBB) following intravenous infusion.LY6A, a novel cellular receptor has been
verified as an essential receptor for AAV-PHP.eB vector.
With the blood-brain barrier(BBB) crossing
propertiy,AAV-PHP.eB shows potential applications in CNS (neuron) gene therapy,especially in
neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD),or neurogenetic
disease such as Spinal Muscular Atrophy (SMA) and Huntington's disease(HD).
Product Name | Organization Type | Price(In USD) | Qty (Quantity) | Sum(In USD) |
---|---|---|---|---|
AAV9-PHP.eB Rep-Cap plasmid Cat.No.:P-RC20 Serotype: AAV-PHP.eB Size: 5ug |
Academic | 1719 | ||
AAV9-PHP.eB Rep-Cap plasmid Cat.No.:P-RC20 Serotype: AAV-PHP.eB Size: 5ug |
Industry R&D (excluding CRO&CDMO&CXO) |
Inquiry | ||
AAV9-PHP.eB Rep-Cap plasmid Cat.No.:P-RC20 Serotype: AAV-PHP.eB Size: 5ug |
CRO&CDMO& CXO&CMC& Manufacturing company |
Inquiry | ||
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service. | ||||
Shipping Cost: | 169.00 | |||
Total: | ||||
Other AAV Rep-Cap Plasmid