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Capsid engineered-AAV serotype 9 variant (AAV9-PHP.eB) system - Introduction

GeneMedi's AAV-PHP.eB Rep-Cap plasmid (specific serotype across (blood-brain barrier(BBB) AAV RC plamid), also named AAV-PHP.eB RC plasmid,is part of AAV-PHP.eB packaging system. AAV-PHP.eB Rep-Cap plamid supplies the AAV2 Rep(replication) proteins and the AAV-PHP.eB capsid protein.

You can produce AAV-PHP.eB paticle in 293T cell line in high titer using GeneMedi's AAV-PHP.eB Rep-Cap plasmid with GeneMedi's AAV expression vector(overexpression or shRNA) and AAV helper plasmid.

AAV-PHP.eB (also called AAV9-PHP.eB) is a variant from AAV9 with AAV capsid evolution (AAV capsid peptide display). With enhanced CNS tropism (neurotropic),the AAV-PHP.eB variant vector has also been validated in gene delivery in vivo across the blood-brain barrier(BBB) following intravenous infusion.LY6A, a novel cellular receptor has been verified as an essential receptor for AAV-PHP.eB vector.

With the blood-brain barrier(BBB) crossing propertiy,AAV-PHP.eB shows potential applications in CNS (neuron) gene therapy,especially in neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD),or neurogenetic disease such as Spinal Muscular Atrophy (SMA) and Huntington's disease(HD).

Product Name Organization Type Price(In USD) Qty (Quantity) Sum(In USD)
AAV9-PHP.eB Rep-Cap plasmid
Cat.No.:P-RC20
Serotype: AAV-PHP.eB
Size: 5ug
Academic 1719
AAV9-PHP.eB Rep-Cap plasmid
Cat.No.:P-RC20
Serotype: AAV-PHP.eB
Size: 5ug
Industry R&D
(excluding
CRO&CDMO&CXO)
Inquiry
AAV9-PHP.eB Rep-Cap plasmid
Cat.No.:P-RC20
Serotype: AAV-PHP.eB
Size: 5ug
CRO&CDMO&
CXO&CMC&
Manufacturing company
Inquiry
Shipping Cost: 169.00
Total:

Other AAV Rep-Cap Plasmid


AAV1 Rep-Cap Plasmid

AAV2 Rep-Cap Plasmid

AAV2 variant (Y444F) Rep-Cap plasmid

AAV2 variant (Y272F, Y444F, Y500F, Y730F) Rep-Cap plasmid

AAV2 variant (Y444F, Y730F, Y500F, Y272F, Y704F, Y252F) Rep-Cap plasmid

AAV2 variant (AAV2.7m8) Rep-Cap plasmid

AAV5 Rep-Cap Plasmid

AAV6 Rep-Cap Plasmid

AAV8 Rep-Cap Plasmid

AAV8-1m Rep-Cap plasmid



AAV8-2m Rep-Cap plasmid

AAV8 variant (Y733F, Y447F, Y275) Rep-Cap plasmid

AAV9 Rep-Cap Plasmid

AAV-Rh.10 Rep-Cap Plasmid

AAV-DJ Rep-Cap Plasmid

AAV-DJ/8 Rep-Cap Plasmid

AAV-Retro (Retrograde) Rep-Cap plasmid

AAV9-PHP.B Rep-Cap plasmid

AAV9-PHP.S Rep-Cap plasmid