AAV-PHP.S vector system (AAV-PHP.S expression and packaging plasmid system, across the blood-brain barrier(BBB) )

GeneMedi (GM) AAV-PHP.S Vector system is including: 1) AAV-PHP.S Rep-Cap plasmid (AAV-PHP.S-RC plasmid) 2) AAV Helper plasmid 3) AAV expression vectors (overexpression or shRNA).

You can produce AAV-PHP.S particle in 293T cell line in high titer using GeneMedi's AAV-PHP.S Rep-Cap plasmid with GM's AAV expression vector (overexpression or shRNA) and AAV helper plasmid.

With the blood-brain barrier(BBB) crossing propertiy, AAV-PHP.B shows potential applications in CNS (neuron) gene therapy, especially in neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), or neurogenetic disease such as Spinal Muscular Atrophy (SMA) and Huntington's disease(HD).

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Product Description

Cat.NO Product Name Organization Type Price(In USD)
P-PK21 AAV-PHP.S Vector System
1. AAV-PHP.S Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
Academic 2664
P-PK21 AAV-PHP.S Vector System
1. AAV-PHP.S Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
Industry R&D
(excluding
CRO&CDMO&CXO)
P-PK21 AAV-PHP.S Vector System
1. AAV-PHP.S Rep-Cap Plasmid, 5ug
2. AAV Helper Plasmid, 5ug
3. pGMAAV-CMV-MCS-T2A-ZsGreen (P-AAVV-B01), 5ug
CRO&CDMO&
CXO&CMC&
Manufacturing company
P-PK21-Kan AAV-PHP.S Vector System(Kan resistance)
1. AAV-PHP.S Rep-Cap Plasmid(Kan resistance), 10mg
2. AAV Helper Plasmid(Kan resistance), 10mg
3. pGMAAV-CMV-MCS-T2A-ZsGreen (Kan resistance) (P-AAVV-B01-Kan), 10mg
All
Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Vector System and do not provide seed stocks.
P-RC21 AAV-PHP.S Rep-Cap Plasmid
Academic 1308
P-RC21 AAV-PHP.S Rep-Cap Plasmid
Industry R&D
(excluding
CRO&CDMO&CXO)
P-RC21 AAV-PHP.S Rep-Cap Plasmid
CRO&CDMO&
CXO&CMC&
Manufacturing company
P-RC21-Kan AAV-PHP.S Rep-Cap Plasmid(Kan resistance)
All
Currently, GeneMedi only offers amplification services for the Kan-resistant AAV Rep-Cap Plasmids and do not provide seed stocks.
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.
Terms of sale:
For Seed (5ug):
The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for any other party.

For plasmid production&lification (≥10mg):
The purchaser may not reverse engineer this product to extract the sequence for independent use. The purchaser may not transfer this product to others for manufacturing purposes. The purchaser may not use this material to manufacture this product for themselves or any other party.

Citation

Title Publication Date
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation Signal Transduction and Targeted Therapy 2023/9/21
Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration Molecular Cancer 2018/10/6
Cobaltosic oxide-polyethylene glycol-triphenylphosphine nanoparticles ameliorate the acute-to-chronic kidney disease transition by inducing BNIP3-mediated mitophagy Kidney international
TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca2+ leakage Nature communications 2022/12/2
AKAP1 Deficiency Attenuates Diet-Induced Obesity and Insulin Resistance by Promoting Fatty Acid Oxidation and Thermogenesis in Brown Adipocytes Advanced Science 2021/2/1
The E3 ubiquitin ligase HUWE1 acts through the N‐Myc‐DLL1‐NOTCH1 signaling axis to suppress glioblastoma progression Cancer Communications 2022/7/18
Targeting metabolic vulnerability in mitochondria conquers MEK inhibitor resistance in KRAS-mutant lung cancer Acta Pharmaceutica Sinica B 2022/10/28
Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells Journal for ImmunoTherapy of Cancer 2021/12/1
Exercise training attenuates angiotensin II-induced cardiac fibrosis by reducing POU2F1 expression Journal of Sport and Health Science 2022/10/29
Keratinocyte-to-macrophage communication exacerbate psoriasiform dermatitis via LRG1-enriched extracellular vesicles Theranostics 2024/1/1


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